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Vitamin D and Muscle

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Nutritional Influences on Bone Health

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Abstract

Vitamin D modulates fracture risk in two ways: by decreasing falls and increasing bone density. Two 2009 metaanalyses of double-blind randomized controlled trials came to the conclusion that vitamin D reduces the risk of falls by 19%, the risk of hip fracture by 18%, and the risk of any nonvertebral fracture by 20%; however, this benefit was dose-dependent. Fall prevention was only observed in trial of at least 700 IU vitamin D per day, and fracture prevention required a received dose (treatment dose*adherence) of more than 400 IU vitamin D per day. Antifall efficacy started with achieved 25-hydroxyvitamin D levels of at least 60 nmol/L (24 ng/mL) and antifracture efficacy started with achieved 25-hydroxyvitamin D levels of at least 75 nmol/L (30 ng/mL) and both end points improved further with higher achieved 25-hydroxyvitamin D levels. Based on these evidence-based data derived from the general older population, vitamin D supplementation should be at least 700–1,000 IU/day and taken with good adherence to cover the needs for both fall and fracture prevention. Ideally, the target range for 25-hydroxyvitamin D should be at least 75 nmol/L, which may need more than 700–1,000 IU vitamin D in individuals with severe vitamin D deficiency or those overweight.

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Authors and Affiliations

  1. Department of Rheumatology and Institute of Physical Medicine, Centre on Aging and Mobility, University Hospital Zurich, Gloria Strasse 25, 8091, Zurich, Switzerland

    Heike Bischoff-Ferrari & Bess Dawson-Hughes

Authors
  1. Heike Bischoff-Ferrari
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  2. Bess Dawson-Hughes
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Correspondence to Heike Bischoff-Ferrari .

Editor information

Editors and Affiliations

  1. University Hospital CHUV, Lausanne, 1006, Switzerland

    Peter Burckhardt

  2. Tufts University Boston, USDA Human Nutrition Research Centre on, 711 Washington Street, Boston, 02111, USA

    Bess Dawson-Hughes

  3. , Foods and Nutrition, Purdue University, 700 W. State Street, West Lafayette, 47907, USA

    Connie Weaver

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Bischoff-Ferrari, H., Dawson-Hughes, B. (2011). Vitamin D and Muscle. In: Burckhardt, P., Dawson-Hughes, B., Weaver, C. (eds) Nutritional Influences on Bone Health. Springer, London. https://doi.org/10.1007/978-1-84882-978-7_15

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  • DOI: https://doi.org/10.1007/978-1-84882-978-7_15

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-977-0

  • Online ISBN: 978-1-84882-978-7

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