Emergency Use of Human Cord Blood

  • Norman Ende
  • Kathleen M. Coakley
  • Kenneth Swan


Historically, the use of placental blood was first advocated by George Rubin of New York in 1914. From the nature of the publication, it was utilized in emergency or semi-emergency conditions.1 In 1934, Soviet surgeon M.S. Malinovski reported on placental blood and 2 years later Bruskin and Farberova reported on 114 transfusions preserved for 6–10 days.


Cord Blood Umbilical Cord Blood Nuclear Explosion Cord Blood Transplant Mass Casualty 
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We thank Lynn Baltimore, Senior Research Librarian at the New Jersey Medical School, for assisting in researching the literature for this manuscript and Donald Allegra, M.D., Infectious Disease, for advice.

This chapter is dedicated to the late Dr. Milton Ende and his staff, the physicians and staff of Obstetrical service of Southside Regional Medical Center, Petersburg, Virginia and the Abraham S. Ende Research Foundation that participated in cord blood research since the early 1960s and performed the first ­temporary cord blood transplant in a patient with lymphoblastic leukemia.


  1. 1.
    Rubin G. Placenta blood for transfusion. N Y Med J. 1914;100:421.Google Scholar
  2. 2.
    Podolsky E. Red Miracle; The Story of Soviet Medicine. Freeport: Books for Libraries Press; 1972.Google Scholar
  3. 3.
    Drew CR. The role of soviet investigators in the development of the blood bank. Am Rev Sov Med. 1943;1(4):360-369.Google Scholar
  4. 4.
    Goodall JR, et al. An inexhaustible source of blood for transfusion and its preservation. Surg Gynecol Obstet. 1938;66:176-178.Google Scholar
  5. 5.
    Boland CR, Craig NS, Jacobs AL. Collection and transfusion of preserved blood. Lancet. 1939;1:388-391.CrossRefGoogle Scholar
  6. 6.
    Coates JB. Blood Program in World War II. Washington: Office of the Surgeon General, Dept. of the Army, United States Army Medical Service; 1964.Google Scholar
  7. 7.
    Bhattacharya N. Placental umbilical cord whole blood transfusion: a safe and genuine blood substitute for patients of the under-resourced world at emergency. J Am Coll Surg. 2005;200(4):557-563.CrossRefPubMedGoogle Scholar
  8. 8.
    Ende N, et al. Potential effectiveness of stored cord blood (non-frozen) for emergency use. J Emerg Med. 1996;14(6):673-677.CrossRefPubMedGoogle Scholar
  9. 9.
    Ende N, et al. Pooled umbilical cord blood as a possible universal donor for marrow reconstitution and use in nuclear accidents. Life Sci. 2001;69(13):1531-1539.CrossRefPubMedGoogle Scholar
  10. 10.
    Mathe G, et al. Transfusions and grafts of homologous bone marrow in humans after accidental high dosage irradiation. Rev Fr Étud Clin Biol. 1959;4(3):226-238.PubMedGoogle Scholar
  11. 11.
    Champlin R. The role of bone marrow transplantation for nuclear accidents: implications of the Chernobyl disaster. Semin Hematol. 1987;24(3 Suppl 2):1-4.PubMedGoogle Scholar
  12. 12.
    Linnemann RE. Soviet medical response to the Chernobyl nuclear accident. JAMA. 1987;258(5):637-643.CrossRefPubMedGoogle Scholar
  13. 13.
    Barker JN, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005;105(3):1343-1347.CrossRefPubMedGoogle Scholar
  14. 14.
    Lister J, et al. Multiple unit HLA-unmatched sex-mismatched umbilical cord blood transplantation for advanced hematological malignancy. Stem Cells Dev. 2007;16(1):177-186.CrossRefPubMedGoogle Scholar
  15. 15.
    Ende M. History of umbilical cord blood transplantation. Lancet. 1995;346(8983):1161.CrossRefPubMedGoogle Scholar
  16. 16.
    Shen BJ, et al. Unrelated, HLA-mismatched multiple human umbilical cord blood transfusion in four cases with advanced solid tumors: initial studies. Blood Cells. 1994;20(2–3):285-292.PubMedGoogle Scholar
  17. 17.
    Weinreb S, et al. Transplantation of unrelated cord blood cells. Bone Marrow Transplant. 1998;22(2):193-196.CrossRefPubMedGoogle Scholar
  18. 18.
    Schoemans H, et al. Adult umbilical cord blood transplantation: a comprehensive review. Bone Marrow Transplant. 2006;38(2):83-93.CrossRefPubMedGoogle Scholar
  19. 19.
    De Lima M, et al. Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Br J Haematol. 2002;119(3):773-776.CrossRefPubMedGoogle Scholar
  20. 20.
    Nagayama H, et al. Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim. Bone Marrow Transplant. 2002;29(3):197-204.CrossRefPubMedGoogle Scholar
  21. 21.
    Ende N, et al. Murine survival of lethal irradiation with the use of human umbilical cord blood. Life Sci. 1992;51(16):1249-1253.CrossRefPubMedGoogle Scholar
  22. 22.
    Ende N, et al. The effect of human cord blood on SJL/J mice after chemoablation and irradiation and its possible clinical significance. Immunol Invest. 1995;24(6):999-1012.CrossRefPubMedGoogle Scholar
  23. 23.
    Rameshwar P, et al. Endogenous hematopoietic reconstitution induced by human umbilical cord blood cells in immunocompromised mice: implications for adoptive therapy. Exp Hematol. 1999;27(1):176-185.CrossRefPubMedGoogle Scholar
  24. 24.
    Czarneski J, et al. Effects of cord blood transfer on the hematopoietic recovery following sublethal irradiation in MRL lpr/lpr mice. Proc Soc Exp Biol Med. 1999;220(2):79-87.CrossRefPubMedGoogle Scholar
  25. 25.
    Ende N. The Berashis cell: a review – is it similar to the embryonic stem cell? J Med. 2000;31(3–4):113-130.PubMedGoogle Scholar
  26. 26.
    Ende N. Berashis cells in human umbilical cord blood vs. embryonic stem cells. J Med. 2002;33(1–4):167-171.PubMedGoogle Scholar
  27. 27.
    Mouiseddine M, et al. Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model. Br J Radiol. 2007;80(Spec No 1):S49-S55.CrossRefPubMedGoogle Scholar
  28. 28.
    Shi C, et al. Transplantation of dermal multipotent cells promotes survival and wound healing in rats with combined radiation and wound injury. Radiat Res. 2004;162(1):56-63.CrossRefPubMedGoogle Scholar
  29. 29.
    Burd A, Ahmed K, Lam S, et al. Stem cell strategies in burns care. Burns. 2007;33(3):282-291.CrossRefPubMedGoogle Scholar
  30. 30.
    Ende M, Ende N. Hematopoietic transplantation by means of fetal (cord) blood. A new method. Va Med Mon (1918). 1972;99(3):276-280.Google Scholar
  31. 31.
    Valbonesi M, Giannini G, Miglori F, et al. Cord blood (CB) stem cells for wound repair. Preliminary report of 2 cases. Transfus Apher Sci 2004;30:153-156.Google Scholar
  32. 32.
    Ende M. Management of the acute radiation syndrome. Ann Intern Med. 2004;141(11):891.PubMedGoogle Scholar

Copyright information

© Springer London 2011

Authors and Affiliations

  • Norman Ende
    • 1
  • Kathleen M. Coakley
  • Kenneth Swan
  1. 1.Department of Pathology and Laboratory Medicine and Department of Surgery, New Jersey Medical SchoolUniversity of Medicine and Dentistry of New JerseyNew JerseyUSA

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