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Cord Blood as a Source of Hematopoietic Progenitors for Transplantation

  • Pilar Solves
  • Amando Blanquer
  • Vicente Mirabet
Chapter

Abstract

Umbilical cord blood (UCB) has become an alternative to bone marrow and peripheral blood as a source of progenitors for hematopoietic stem cell (HSC) transplantation, and its use has increased greatly in recent years. Although UCB has broad spectrum of possible uses, allogeneic HSC transplantation is the major current indication. In this chapter, a description of the umbilical cord blood characteristics is presented and the factors influencing HSC of UCB are reviewed. In order to support the increasing clinical activity, UCB banks have been established all over the world. The different activities involving UCB banking are also explained. Finally, a summary of selected clinical trials using UCB for related and unrelated HSC transplantation is presented.

Keywords

Cord Blood Umbilical Cord Blood Cord Blood Transplantation Cell Dose Total Nucleate Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer London 2011

Authors and Affiliations

  1. 1.Cord Blood BankValencia Transfusion Center and Valencia Transfusion CenterValenciaSpain

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