Medical Imaging in Clinical Trials

pp 327-357


Contrast Agents in Radiology

  • Hendrik von Tengg-KobligkAffiliated withInstitute for Diagnostic, Interventional, and Pediatric Radiology (DIPR), Inselspital—University Hospital BernDepartment of Diagnostic and Interventional Radiology (DIR), University Hospitals HeidelbergDepartment of Radiology, German Cancer Research Center (DKFZ) Email author 
  • , Amit MehndirattaAffiliated withDepartment of Engineering Science, Institute of Biomedical Engineering, Old Road Campus Research Building, University of Oxford
  • , Frederik L. GieselAffiliated withDepartment of Nuclear Medicine, University Hospitals Heidelberg

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To noninvasively diagnose disease and to describe response to therapy regarding morphology (e.g., size, structure) and (patho)physiology (e.g., blood perfusion) as well as cell function optimal image contrast is key. In our various body compartments in vivo contrast can be altered and improved by changing its intensity and distribution over time. This imaging fortune has been established by various contrast agents typically administered intravenously. Imaging methods in the field of ultrasound, magnetic resonance imaging, as well as computed tomography are continuously being improved by safe, valid, and efficient contrast agents. New targeted and specific agents are in the pipeline, but there are still a few more steps to go to reach market approval.


Different contrast media Iodinated contrast media MR contrast media Ultrasound contrast media Imaging Imaging agents