Abstract
Pruritus can be defined as an unpleasant cutaneous sensation that leads to the need to scratch. Pain is defined by the International Association for the Study of Pain (IASP) as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.”
Experiences that resemble pain or itch but are not unpleasant, e.g., pricking or tickling, should not be called pain or itch. Tickle is a sensation with two components: a light pre-noxious sensation (knismesis) and laughter-associated sensation (gargalesis).2
Keywords
- Dorsal Horn
- Vasoactive Intestinal Peptide
- Dorsal Horn Neuron
- Secondary Somatosensory Cortex
- Chronic Itch
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Ständer S, Schmelz M. Chronic itch and pain - similarities and differences. Eur J Pain. 2006;10:473-478.
Seledn ST. Tickle. J Am Acad Dermatol. 2004; 50:93-97.
Misery L. Are pruritus and scratching the cough of the skin? Dermatology. 2008;216:3-5.
Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M. The neurobiology of itch. Nat Rev. 2006;7:535-547.
Bohm-Starke N, Hilliges M, Brodda-Jansen G, Rylander E, Toerbjörk E. Psychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndrome. Pain. 2001;94:177-183.
Zhang X, Huang J, Mac Naughton PA. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J. 2005;24:4211-4223.
Van Laarhoven AIM, Kraaimaat FW, Wilder-Smith OH, et al. Generalzed and symptom-specific sensitization of chronic itch and pain. J Eur Acad Dermatol Venereol. 2007;21:1187-1192.
Stefan H, Feuerstein TJ. Novel anticonvulsivant drugs. Pharmacol Ther. 2007;113:165-183.
Paus R, Schmelz M, Biro T, Steinhoff M. Frontiers in pruritus research: scartching the brain for more effective therapy. J Clin Invest. 2006;116:1174-1185.
Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE. Specific C-receptors for itch in human skin. J Neurosci. 1997;17:2003-2008.
Johanek LM, Meyer RA, Hartke T, et al. Psychopysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci. 2007;27:7490-7497.
Andrew D, Craig AD. Spiothalamaic lamina 1 neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci. 2001;4:72-77.
Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ. The itch-producing agents histamine activate separate populations of primate spinothalaamic tract neurons. J Neurosci. 2007;27:10007-10014.
Drzezga A, Darsow U, Treede RD, et al. Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O15 H2O poistron emission tomography studies. Pain. 2001;92:295-305.
Yosipovitch G, Fast K, Berhard JD. Noxious heat and scratching decrease histamine-induced itch and skin blood flow. J Invest Dermatol. 2005;125:1268-1272.
Dalgard F, Dawn AG, Yosipovitch G. Are itch and chronic pain associated in adults? Results of a large population survey in Norway. Dermatology. 2007;214:305-309.
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Misery, L. (2010). Pruritus, Pain and Other Abnormal Skin Sensations. In: Misery, L., Ständer, S. (eds) Pruritus. Springer, London. https://doi.org/10.1007/978-1-84882-322-8_10
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