Skip to main content

Diabetes Prevention Interventions for Women with a History of GDM

  • Chapter
  • First Online:

Abstract

Women with a history of gestational diabetes (GDM) are at increased risk of later developing type 2 diabetes. Lifestyle modification interventions promoting weight loss and pharmacotherapy interventions to improve insulin sensitivity have been shown to be effective in preventing or delaying the onset of type 2 diabetes in older women with impaired glucose tolerance and/or a previous pregnancy complicated by GDM. This chapter reviews interventions aimed at reducing the incidence of type 2 diabetes for women with a history of GDM. The chapter also presents the few available, small-scale lifestyle interventions for weight management during pregnancy and/or during the early postpartum period; these potential interventions could be applied to women soon after a diagnosis of GDM in order to reduce their lifetime risk of developing type 2 diabetes. We present evidence supporting a lifestyle modification intervention that would begin during pregnancy and continue through the postpartum period, as pharmacotherapy interventions may not be appropriate for pregnant women or women of reproductive age who may intend to become pregnant. However, young women with GDM may not be aware of their diabetes risk and may perceive difficulty in changing lifestyle behaviors. Thus, novel approaches are necessary to translate lifestyle modifications previously proven effective in older women with impaired glucose tolerance to younger women with a recent history of GDM, particularly those with normal glucose tolerance postpartum. Directions for future research include randomized clinical trials assessing the effectiveness of lifestyle modification interventions targeting women with current GDM or a recent pregnancy complicated by GDM. Understanding the barriers to increasing physical activity and adopting a healthy diet, and learning how preventative lifestyle modifications may best be integrated into the busy schedules of young women caring for young children, are crucial.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Cheung NW, Byth K. Population health significance of gestational diabetes. Diab Care. 2003;26:2005-2009.

    Article  Google Scholar 

  2. Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773-1779.

    Article  CAS  PubMed  Google Scholar 

  3. Bentley-Lewis R. Gestational diabetes mellitus: an opportunity of a lifetime. Lancet. 2009;373:1738-1740.

    Article  PubMed  Google Scholar 

  4. England LJ, Dietz PM, Njoroge T, et al. Preventing type 2 diabetes: public health implications for women with a history of gestational diabetes mellitus. Am J Obstet Gynecol. 2009;200:365-368.

    Article  PubMed  Google Scholar 

  5. Ratner RE, Christophi CA, Metzger BE, et al. Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions. J Clin Endocrinol Metab. 2008;93:4774-4779.

    Article  CAS  PubMed  Google Scholar 

  6. Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diab Care. 2002;25:1862-1868.

    Article  Google Scholar 

  7. Nicholls JS, Chan SP, Ali K, Beard RW, Dornhorst A. Insulin secretion and sensitivity in women fulfilling WHO criteria for gestational diabetes. Diabet Med. 1995;12:56-60.

    Article  CAS  PubMed  Google Scholar 

  8. Metzger BE, Cho NH, Roston SM, Radvany R. Prepregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes mellitus. Diab Care. 1993;16:1598-1605.

    Article  CAS  Google Scholar 

  9. Damm P, Kuhl C, Bertelsen A, Molsted-Pedersen L. Predictive factors for the development of diabetes in women with previous gestational diabetes mellitus. Am J Obstet Gynecol. 1992;167:607-616.

    Article  CAS  PubMed  Google Scholar 

  10. Kaaja RJ, Greer IA. Manifestations of chronic disease during pregnancy. JAMA. 2005;294:2751-2757.

    Article  CAS  PubMed  Google Scholar 

  11. Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest. 2005;115:485-491.

    CAS  PubMed Central  PubMed  Google Scholar 

  12. Ferrara A, Peng T, Kim C. Trends in postpartum diabetes screening and subsequent diabetes and impaired fasting glucose among women with histories of gestational diabetes mellitus. A report from the Translating Research Into Action for Diabetes (TRIAD) Study. Diab Care. 2008;32(2):269-274.

    Article  Google Scholar 

  13. Schaefer-Graf UM, Buchanan TA, Xiang AH, Peters RK, Kjos SL. Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus. Am J Obstet Gynecol. 2002;186:751-756.

    Article  PubMed  Google Scholar 

  14. Kjos SL, Buchanan TA, Greenspoon JS, Montoro M, Bernstein GS, Mestman JH. Gestational diabetes mellitus: the prevalence of glucose intolerance and diabetes mellitus in the first two months post partum. Am J Obstet Gynecol. 1990;163:93-98.

    Article  CAS  PubMed  Google Scholar 

  15. Kjos SL, Peters RK, Xiang A, Henry OA, Montoro M, Buchanan TA. Predicting future diabetes in Latino women with gestational diabetes. Utility of early postpartum glucose tolerance testing. Diabetes. 1995;44:586-591.

    Article  CAS  PubMed  Google Scholar 

  16. Lam KS, Li DF, Lauder IJ, Lee CP, Kung AW, Ma JT. Prediction of persistent carbohydrate intolerance in patients with gestational diabetes. Diab Res Clin Pract. 1991;12:181-186.

    Article  CAS  Google Scholar 

  17. Catalano PM, Vargo KM, Bernstein IM, Amini SB. Incidence and risk factors associated with abnormal postpartum glucose tolerance in women with gestational diabetes. Am J Obstet Gynecol. 1991;165:914-919.

    Article  CAS  PubMed  Google Scholar 

  18. Coustan DR, Carpenter MW, O’Sullivan PS, Carr SR. Gestational diabetes: predictors of subsequent disordered glucose metabolism. Am J Obstet Gynecol. 1993;168:1139-1144.

    Article  CAS  PubMed  Google Scholar 

  19. Steinhart JR, Sugarman JR, Connell FA. Gestational diabetes is a herald of NIDDM in Navajo women. High rate of abnormal glucose tolerance after GDM. Diab Care. 1997;20:943-947.

    Article  CAS  Google Scholar 

  20. Kaufmann RC, Schleyhahn FT, Huffman DG, Amankwah KS. Gestational diabetes diagnostic criteria: long-term maternal follow-up. Am J Obstet Gynecol. 1995;172:621-625.

    Article  CAS  PubMed  Google Scholar 

  21. O’Sullivan JB. Gestational diabetes: factors influencing the rates of subsequent diabetes. In: Sutherland HW, Stowers JM, eds. Carbohydrate Metabolism During Pregnancy and the Newborn 1978. Berlin, Germany: Springer; 1979:425-435.

    Chapter  Google Scholar 

  22. Peters RK, Kjos SL, Xiang A, Buchanan TA. Long-term diabetogenic effect of single pregnancy in women with previous gestational diabetes mellitus [see comments]. Lancet. 1996;347:227-230.

    Article  CAS  PubMed  Google Scholar 

  23. Keppel KG, Taffel SM. Pregnancy-related weight gain and retention: implications of the 1990 Institute of Medicine guidelines. Am J Public Health. 1993;83:1100-1103.

    Article  CAS  PubMed  Google Scholar 

  24. Institute of Medicine, National Academy of Sciences, Food and Nutrition Board. Nutrition During Pregnancy. Part I Weight Gain. Washington, DC: National Academy Press; 1990.

    Google Scholar 

  25. Stage E, Ronneby H, Damm P. Lifestyle change after gestational diabetes. Diab Res Clin Pract. 2004;63:67-72.

    Article  CAS  Google Scholar 

  26. Greene GW, Smiciklas-Wright H, Scholl TO, Karp RJ. Postpartum weight change: how much of the weight gained in pregnancy will be lost after delivery? Obstet Gynecol. 1988;71:701-707.

    CAS  PubMed  Google Scholar 

  27. Linne Y, Dye L, Barkeling B, Rossner S. Weight development over time in parous women–the SPAWN study–15 years follow-up. Int J Obes Relat Metab Disord. 2003;27:1516-1522.

    Article  CAS  PubMed  Google Scholar 

  28. Linne Y, Dye L, Barkeling B, Rossner S. Long-term weight development in women: a 15-year follow-up of the effects of pregnancy. Obes Res. 2004;12:1166-1178.

    Article  PubMed  Google Scholar 

  29. Hedderson MM, Weiss NS, Sacks DA, et al. Pregnancy weight gain and risk of neonatal complications: macrosomia, hypoglycemia, and hyperbilirubinemia. Obstet Gynecol. 2006;108:1153-1161.

    Article  PubMed  Google Scholar 

  30. Cheng YW, Chung JH, Kurbisch-Block I, Inturrisi M, Shafer S, Caughey AB. Gestational weight gain and gestational diabetes mellitus: perinatal outcomes. Obstet Gynecol. 2008;112:1015-1022.

    Article  PubMed  Google Scholar 

  31. Polley BA, Wing RR, Sims CJ. Randomized controlled trial to prevent excessive weight gain in pregnant women. Int J Obes Relat Metab Disord. 2002;26:1494-1502.

    Article  CAS  PubMed  Google Scholar 

  32. Wolff S, Legarth J, Vangsgaard K, Toubro S, Astrup A. A randomized trial of the effects of dietary counseling on gestational weight gain and glucose metabolism in obese pregnant women. Int J Obes (Lond). 2008;32:495-501.

    Article  CAS  Google Scholar 

  33. Artal R, Catanzaro RB, Gavard JA, Mostello DJ, Friganza JC. A lifestyle intervention of weight-gain restriction: diet and exercise in obese women with gestational diabetes mellitus. Appl Physiol Nutr Metab. 2007;32:596-601.

    Article  PubMed  Google Scholar 

  34. O’Toole ML, Sawicki MA, Artal R. Structured diet and physical activity prevent postpartum weight retention. J Womens Health (Larchmt). 2003;12:991-998.

    Article  Google Scholar 

  35. Leermakers EA, Anglin K, Wing RR. Reducing postpartum weight retention through a correspondence intervention. Int J Obes Relat Metab Disord. 1998;22:1103-1109.

    Article  CAS  PubMed  Google Scholar 

  36. Lovelady CA, Garner KE, Moreno KL, Williams JP. The effect of weight loss in overweight, lactating women on the growth of their infants. N Engl J Med. 2000;342:449-453.

    Article  CAS  PubMed  Google Scholar 

  37. Lovelady CA, Nommsen-Rivers LA, McCrory MA, Dewey KG. Effects of exercise on plasma lipids and metabolism of lactating women. Med Sci Sports Exerc. 1995;27:22-28.

    Article  CAS  PubMed  Google Scholar 

  38. Albright CL, Maddock JE, Nigg CR. Increasing physical activity in postpartum multiethnic women in Hawaii: results from a pilot study. BMC Womens Health. 2009;9:4.

    Article  PubMed Central  PubMed  Google Scholar 

  39. Pereira MA, Rifas-Shiman SL, Kleinman KP, Rich-Edwards JW, Peterson KE, Gillman MW. Predictors of change in physical activity during and after pregnancy: Project Viva. Am J Prev Med. 2007;32:312-319.

    Article  PubMed Central  PubMed  Google Scholar 

  40. Symons DD, Ulbrecht JS. Understanding exercise beliefs and behaviors in women with gestational diabetes mellitus. Diab Care. 2006;29:236-240.

    Article  Google Scholar 

  41. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403.

    Article  CAS  PubMed  Google Scholar 

  42. Buchanan TA, Xiang AH, Peters RK, et al. Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes. 2002;51(9):2796-2803.

    Article  CAS  PubMed  Google Scholar 

  43. Buchanan TA, Xiang AH, Peters RK, et al. Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes. Diabetes. 2000;49:782-788.

    Article  CAS  PubMed  Google Scholar 

  44. Kieffer EC, Carman WJ, Gillespie BW, Nolan GH, Worley SE, Guzman JR. Obesity and gestational diabetes among African-American women and Latinas in Detroit: implications for disparities in women’s health. J Am Med Womens Assoc. 2001;56:181-187,196.

    Google Scholar 

  45. Tuomilehto J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343-1350.

    Article  CAS  PubMed  Google Scholar 

  46. Keller C, Records K, Ainsworth B, Permana P, Coonrod DV. Interventions for weight management in postpartum women. J Obstet Gynecol Neonatal Nurs. 2008;37:71-79.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Assiamira Ferrara .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer London

About this chapter

Cite this chapter

Ferrara, A., Ehrlich, S.F. (2010). Diabetes Prevention Interventions for Women with a History of GDM. In: Kim, C., Ferrara, A. (eds) Gestational Diabetes During and After Pregnancy. Springer, London. https://doi.org/10.1007/978-1-84882-120-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-84882-120-0_24

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-119-4

  • Online ISBN: 978-1-84882-120-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics