Fibrotic Skin Diseases

  • Dermal fibrosis is excessive scarring of the skin, and is a result of a pathologic wound healing response.

  • There is a wide spectrum of fibrotic skin diseases: scleroderma, nephrogenic fibrosing dermopathy, mixed connective tissue disease, scleromyxedema, scleredema, and eosinophilic fasciitis. Exposures to chemicals or physical agents are also potential causes of fibrotic skin disease.

  • Dermal fibrosis may be driven by immune, autoimmune, and inflammatory mechanisms.

  • The balance of collagen production and degradation by fibroblasts plays a critical role in the pathophysiology of fibrotic processes in the skin.

  • Certain cytokines promote would healing and fibrosis, such as transforming growth factor-β (TGF-β) and interleukin-4 (IL-4), whereas others are antifibrotic, such as interferon-γ (IFN-γ) and transforming growth factor-α (TNF-α).


Idiopathic Pulmonary Fibrosis Systemic Sclerosis Connective Tissue Growth Factor Dermal Fibroblast Hypertrophic Scar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag London Limited 2008

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Maryland School of MedicineBaltimoreUSA

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