Skip to main content
Book cover

Clinical and Basic Immunodermatology pp 17–29Cite as

Innate and Adaptive Immunity

  • Chapter

Keywords

  • Dendritic Cell
  • Atopic Dermatitis
  • Adaptive Immunity
  • iNKT Cell
  • Plasmacytoid Dendritic Cell

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-84800-165-7_2
  • Chapter length: 13 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   74.99
Price excludes VAT (USA)
  • ISBN: 978-1-84800-165-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   99.00
Price excludes VAT (USA)
Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tauber AI, Chernyak L. Metchnikoff and the Origins of Immunology: From Metaphor to Theory. New York: Oxford University Press, 1991.

    Google Scholar 

  2. Bos JD, Kapsenberg ML. The skin immune system (SIS): its cellular constituents and their interactions. Immunol Today 1986;7:235–40.

    CrossRef  Google Scholar 

  3. Bos JD, ed. Skin Immune System (SIS), 1st ed. Boca Raton, FL: CRC Press, 1990.

    Google Scholar 

  4. Teunissen MBM, Piskin G, di Nuzzo S, et al. Ultraviolet B radiation induces a transient appearance of IL-4+ neutrophils, which support the development of Th2 responses. J Immunol 2002;168:3732–9.

    PubMed  CAS  Google Scholar 

  5. Janeway CA. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989;54:1–13.

    PubMed  CAS  Google Scholar 

  6. Bonizzi G, Karin M. The two NF-?B activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004;25:280–8.

    CrossRef  PubMed  CAS  Google Scholar 

  7. Teunissen MBM. Langerhans cells and other skin dendritic cells. In: Bos JD, ed. Skin Immune System (SIS): Cutaneous Immunology and Clinical Immunodermatology, 3rd edition. Boca Raton, FL: CRC Press, 2005:123–82.

    Google Scholar 

  8. Banchereau J, Steinman M. Dendritic cells and the control of immunity. Nature 1998;392:245–52.

    CrossRef  PubMed  CAS  Google Scholar 

  9. Lebre MC, Van der Aar AMG, Van Baarsen L, et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 2007;127:331–41.

    CrossRef  PubMed  CAS  Google Scholar 

  10. Wollenberg A, Kraft S, Hanau D, et al. Immunological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. J Invest Dermatol 1996;106:446–53.

    CrossRef  PubMed  CAS  Google Scholar 

  11. Bieber T. FcεRI-expressing antigen-presenting cells: new players in the atopic game. Immunol Today 1997;18:311–3.

    CrossRef  PubMed  CAS  Google Scholar 

  12. Lowes MA, Chamian F, Abello MV, et al. Increase in TNF-α and inducible nitric oxide synthase-express-ing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA 2005;102:19057–62.

    CrossRef  PubMed  CAS  Google Scholar 

  13. De Vries HJC, Van Marle J, Teunissen MBM, et al. Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells. Br J Dermatol 2006;154:361–4.

    CrossRef  PubMed  CAS  Google Scholar 

  14. Nestle FO, Conrad C, Tun-Kyi A, et al. Plasmacytoid predendritic cells initiate psoriasis through inter-feron-α production. J Exp Med 2005;202:135–43.

    CrossRef  PubMed  CAS  Google Scholar 

  15. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783–801.

    CrossRef  PubMed  CAS  Google Scholar 

  16. Ting JPY, Kastner DL, Hoffman HM. CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol 2006;6:183–95.

    CrossRef  PubMed  CAS  Google Scholar 

  17. Robinson MJ, Sancho D, Slack EC, et al. Myeloid C-type lectins in innate immunity. Nat Immunol 2006;12:1258–65.

    CrossRef  CAS  Google Scholar 

  18. Van der Aar AMG, Sylva-Steenland RMR, Bos JD, et al. Cutting edge: loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition. J Immunol 2007;178:1986–900.

    PubMed  Google Scholar 

  19. Medzhitov R, Janeway CA. Innate immunity. N Engl J Med 2000;343:338–44.

    CrossRef  PubMed  CAS  Google Scholar 

  20. Esche C, Stellato C, Beck LA. Chemokines: key players in innate and adaptive immunity. J Invest Dermatol 2005;125:615–28.

    CrossRef  PubMed  CAS  Google Scholar 

  21. McGirt LY, Beck LA. Innate immune defects in atopic dermatitis. J Allergy Clin Immunol 2006;118:202–8.

    CrossRef  PubMed  CAS  Google Scholar 

  22. Bos JD, De Rie MA, Teunissen MBM, et al. Psoriasis: activation of innate immunity. Br J Dermatol 2005;152:1098–107.

    CrossRef  PubMed  CAS  Google Scholar 

  23. Chu AC, Morris JF. The keratinocyte. In: Bos JD, ed. Skin Immune System (SIS): Cutaneous Immunology and Clinical Immunodermatology, 3rd edition. Boca Raton, FL: CRC Press, 2005:77–99.

    Google Scholar 

  24. Piskin G, Sylva-Steenland RMR, Bos JD, et al. In vitro and in vivo expression of IL-23 by kerati-nocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol 2006;176:1908–15.

    PubMed  CAS  Google Scholar 

  25. Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP. Nat Immunol 2002;3:673–80.

    CrossRef  PubMed  CAS  Google Scholar 

  26. Furth R van, Cohn ZA, Hirsch JG, et al. The mono-nuclear phagocyte system: a new classification of macrophages, monocytes and their precursor cells. Bull WHO 1972;46:845–52.

    PubMed  Google Scholar 

  27. Lu KQ, McCormick TS, Gilliam AC, et al. Monocytes and macrophages in human skin. In: Bos JD, ed. Skin Immune System (SIS): Cutaneous Immunology and Clinical Immunodermatology, 3rd edition. Boca Raton, FL: CRC Press, 2005:183–209.

    Google Scholar 

  28. Knol EF, Kuijpers TW, Roos D. Neutrophils, eosinophils and basophils in the skin immune system. In: Bos JD, ed. Skin Immune System (SIS): Cutaneous Immunology and Clinical Immunodermatology, 3rd edition. Boca Raton, FL: CRC Press, 2005:263–83.

    Google Scholar 

  29. Zhang C, Zhang J, Tian Z. The regulatory effect of natural killer cells: do “NK-reg cells” exist? Cell Mol Immunol 2006;3:241–54.

    Google Scholar 

  30. Orange JS. Human natural killer cell deficiencies. Curr Opin Allergy Clin Immunol 2006;6:399–409.

    CrossRef  PubMed  Google Scholar 

  31. Godfrey DI, MacDonald RH, Kronenberg M, et al. NKT cells: what's in a name? Nat Rev Immunol 2004;4:231–7.

    CrossRef  PubMed  CAS  Google Scholar 

  32. Karadimitris A, Patterson S, Spanoudakis E. Natural killer T cells and haemopoiesis. Br J Haematol 2006;134:263–72.

    CrossRef  PubMed  CAS  Google Scholar 

  33. Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 2004;114:1379–88.

    PubMed  CAS  Google Scholar 

  34. Cameron AL, Kirby B, Fei W, et al. Natural killer and natural killer-T cells in psoriasis. Arch Dermatol Res 2002;294:363–9.

    PubMed  CAS  Google Scholar 

  35. Van der Vliet HJJ, Von Blomberg BME, Nishi N, et al. Circulating Va24>+ Vß11>+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin Immunol 2001;100:144–8.

    CrossRef  PubMed  Google Scholar 

  36. Bonish B, Jullien D, Dutronc Y, et al. Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-γ production by NK-T cells. J Immunol 2000;165:4076–85.

    PubMed  CAS  Google Scholar 

  37. Clark RA, Chong B, Mirchandani N, et al. The vast majority of CLA+ T cells are resident in normal skin. J Immunol 2006;176:4431–9.

    PubMed  CAS  Google Scholar 

  38. Bos JD, Zonneveld I, Das PK, et al. The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 1987;88:569–73.

    CrossRef  Google Scholar 

  39. Santamaria-Babi LF. CLA(+) T cells in cutaneous diseases. Eur J Dermatol 2004;14:13–8.

    Google Scholar 

  40. Dudda JSSC, Simon JC, Martin S. Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets. J Immunol 2004;172:857–63.

    PubMed  CAS  Google Scholar 

  41. Gutgesell C, Heise S, Seubert A, et al. Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores. Br J Dermatol 2002;147:914–9.

    CrossRef  PubMed  CAS  Google Scholar 

  42. Kapsenberg ML. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003;3:984–93.

    CrossRef  PubMed  CAS  Google Scholar 

  43. Weaver CT, Harrington LE, Mangan PR, et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006;24:677–88.

    CrossRef  PubMed  CAS  Google Scholar 

  44. Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a TH17 cytokine, mediates IL-23—induced dermal inflammation and acanthosis. Nature 2007;445:648–51.

    CrossRef  PubMed  CAS  Google Scholar 

  45. Liang SC, Tan XY, Luxenberg DP, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006;203:2271–.

    CrossRef  PubMed  CAS  Google Scholar 

  46. Teunissen MBM, Koomen CW, de Waal Malefyt R, et al. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 1998;111:645–9.

    CrossRef  PubMed  CAS  Google Scholar 

  47. Beissert S, Schwarz A, Schwarz T. Regulatory T cells. J Invest Dermatol 2006;126:15–24.

    CrossRef  PubMed  CAS  Google Scholar 

  48. De Boer OJ, Van der Loos CM, Teeling P, et al. Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4+CD25>+ T cells in normal skin and inflammatory dermatoses. J Histochem Cytochem 2007;55:891–8.

    CrossRef  PubMed  CAS  Google Scholar 

  49. Sugiyama H, Gyulai R, Toichi E, et al. Dysfunctional blood and target tissue CD4+CD25>high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005;174:164–73.

    PubMed  CAS  Google Scholar 

  50. Bos JD, ed. Skin Immune System (SIS): Cutaneous Immunology and Clinical Immunodermatology, 3rd ed. Boca Raton, FL: CRC Press, 2005.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Jan D. Bos & Marcel B. M. Teunissen

Authors
  1. Jan D. Bos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marcel B. M. Teunissen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA

    Anthony A. Gaspari MD

  2. Department of Dermatology, University of Texas Medical School at Houston, Houston, TX, USA

    Stephen K. Tyring MD, PhD

Rights and permissions

Reprints and Permissions

Copyright information

© 2008 Springer-Verlag London Limited

About this chapter

Cite this chapter

Bos, J.D., Teunissen, M.B.M. (2008). Innate and Adaptive Immunity. In: Gaspari, A.A., Tyring, S.K. (eds) Clinical and Basic Immunodermatology. Springer, London. https://doi.org/10.1007/978-1-84800-165-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-84800-165-7_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84800-164-0

  • Online ISBN: 978-1-84800-165-7

  • eBook Packages: MedicineMedicine (R0)