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Pathophysiology—Clinical Spectrum and Current Management

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Management of Heart Failure
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References

  1. Thomas L. The artificial heart. In: Late Night Thoughts on Listening to Mahler's Ninth Symphony. Viking Penguin, New York; 1983.

    Google Scholar 

  2. Willerson JT, Delgado R III, Mann D. Treating relentlessly progressive congestive heart failure: What next? Tex Heart Inst J. 1998;25:235–237.

    PubMed  CAS  Google Scholar 

  3. Gheorghiade M, Bonow RO. Chronic heart failure in the United States: A manifestation of coronary artery disease. Circulation. 1998;97:282–289.

    PubMed  CAS  Google Scholar 

  4. Willerson JT. Other cardiomyopathies. In: Willerson JT, Cohn JN eds. Cardiovascular Medicine. New York: Churchill Livingstone; 1995:888–894.

    Google Scholar 

  5. Luppi P, Rudert WA, Zanone MM, Stassi G, Finegold D, et al. Idiopathic dilated cardiomyopathy: A super-antigen driven autoimmune disease. Circulation. 1998;98:777–785.

    PubMed  CAS  Google Scholar 

  6. Cohn JN. Overview of pathophysiology of clinical heart failure. In: Hosenpud JD, Greenberg BH eds. Congestive Heart Failure: Pathophysiology, Diagnosis and Comprehensive Approach to Management. New York: Springer-Verlag; 1994:11–16.

    Google Scholar 

  7. Katz AM. The cardiomyopathy of overload: An unnatural growth response in the hypertrophied heart. Ann Intern Med. 1994;121:363–371.

    PubMed  CAS  Google Scholar 

  8. McKay RG, Pfeffer MA, Pasternak RC, et al. Left ventricular remodelling after myocardial infarction: A corollary to infarct expansion. Circulation. 1986;74:693–702.

    PubMed  CAS  Google Scholar 

  9. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Pro-inflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol. 1996;27:1201–1206.

    Article  PubMed  CAS  Google Scholar 

  10. Haywood GA, Tsao PS, von der Leyden HE, et al. Expression of inducible nitric oxide synthase in human heart failure. Circulation. 1996;93:1087–1094.

    PubMed  CAS  Google Scholar 

  11. Oral J, Kapadia S, Nakano M, et al. Tumour necrosis factor-alpha and the failing human heart. Clin Cardiol. 1995;18(suppl 4):IV20–IV27.

    Article  PubMed  CAS  Google Scholar 

  12. Li G, Willerson JT. Molecular biologic alterations in heart failure. In: Frazier OH ed. Support and Replacement of the Failing Heart. Philadelphia: Linppincott-Raven; 1996:69–74.

    Google Scholar 

  13. Anversa P, Kajstura J, Olivetti M. Myocyte death in heart failure. Curr Opin Cardiol. 1996;11:245–251.

    Article  PubMed  CAS  Google Scholar 

  14. Hosenpud JD, Greenberg BH, eds. Congestive Heart Failure: Pathophysiology, Diagnosis and Comprehensive Approach to Management. New York: Springer-Verlag; 1994:623–624.

    Google Scholar 

  15. Bonow RO, Udelson JE. Left ventricular diastolic dysfunction as a cause of congestive heart failure: Mechanisms and management. Ann Intern Med. 1992;117:502–510.

    PubMed  CAS  Google Scholar 

  16. Vasan RS, Benjamin EJ, Levy D. Prevalence, clinical features and prognosis of diastolic heart failure: An epidemiologic perspective. J Am Coll Cardiol. 1995;26:1565–1574.

    Article  PubMed  CAS  Google Scholar 

  17. Willerson JT, Cohn JN, eds. Cardiovascular Medicine. New York: Churchill-Livingstone; 1995:952–953.

    Google Scholar 

  18. Benedict CR. Neurohumoral aspects of heart failure. Cardiol Clin. 1994;12:9–23.

    PubMed  CAS  Google Scholar 

  19. Hosenpud JD, Greenberg BH, eds. Congestive Heart Failure: Pathophysiology, Diagnosis and Comprehensive Approach to Management. New York: Springer-Verlag; 1994:13–14.

    Google Scholar 

  20. Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311:819–823.

    Article  PubMed  CAS  Google Scholar 

  21. Meredith IT, Eisenhofer G, Lambert GW, Dewar EM, Jennings GL, Esler M. Cardiac sympathetic nervous activity in congestive heart failure: Evidence for increased neuronal norepinephrine release and preserved neuronal uptake. Circulation. 1993;88:136 –145.

    PubMed  CAS  Google Scholar 

  22. Wei CM, Lerman A, Rodeheffer RJ, et al. Endothelin in human congestive heart failure. Circulation. 1994;89:1580 –1586.

    PubMed  CAS  Google Scholar 

  23. Mestroni L, Giacca M. Molecular genetics of dilated cardiomyopathy. Curr Opin Cardiol. 1997;12: 203–209.

    Article  Google Scholar 

  24. Towbin JA, Hejtmancik JF, Brink A, et al. X-linked dilated cardiomyopathy: Molecular genetic evidence of the Duchenne muscular dystrophy (dystrophin) gene at Xp21 locus. Circulation. 1993;87:1854–1865.

    PubMed  CAS  Google Scholar 

  25. Cintron G, Bigas C, Linares E, Aranda JM, Hernandez E. Nurse practitioner role in a chronic congestive heart failure clinic. In hospital time, costs and past satisfaction. Heart Lung. 1983;12:237–240.

    PubMed  CAS  Google Scholar 

  26. Rich MW, Beckman V, Wittenber C, Level CL, Freedland KE, Carney RM. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med. 1995;33:1190–1195.

    Article  Google Scholar 

  27. Smith LE, Fabri SA, Pai R, Ferry D, Heywood T. Symptomatic improvement and reduced hospitalization for patients attending a cardiomyopathy clinic. Clin Cardiol. 1997;20:949–954.

    Article  PubMed  CAS  Google Scholar 

  28. Shepherd J, Cobbe SM, Ford I, et al., for the West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med. 1995;333:1301–1307.

    Article  PubMed  CAS  Google Scholar 

  29. Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study(4S). Lancet. 1994;344:1382–1389.

    Google Scholar 

  30. Squires RW, Lavie CJ, Brandt TR, Gau GT, Bailey KR. Cardiac rehabilitation in patients with severe left ventricular dysfunction. Mayo Clin Proc. 1987;62:997–1002.

    PubMed  CAS  Google Scholar 

  31. Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997;336:523–533.

    Google Scholar 

  32. Packer M, Carver JR, Rodeheffer RJ, et al. for the PROMISE Study Research Group. Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med. 1991;325:1468–1475.

    Article  PubMed  CAS  Google Scholar 

  33. Cohn JN, Archibald DG, Ziesche S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: Results of a Veterans' Administration Co-operative Study. N Engl J Med. 1986;314: 1547–1552.

    Article  PubMed  CAS  Google Scholar 

  34. Cohn JN, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine-isosorbide nitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991;325:303–310.

    Article  PubMed  CAS  Google Scholar 

  35. The Multi-center Diltiazem Post-infarction Research Group. The effect of diltiazem on mortality and re-infarction after myocardial infarction. N Engl J Med. 1988;319:385–392.

    Google Scholar 

  36. Packer M, O'Connor CM, Ghali JK, et al., for the Prospective Randomized Amlodipine Survival Evaluation Study. Effect of Amlodipine on morbidity and mortality in severe chronic heart failure. N Engl J Med. 1996;335:1107–1114.

    Article  PubMed  CAS  Google Scholar 

  37. Packer M, Bristow MR, Cohn JN, et al., for the U.S. Carvedilol Heart Failure Study Group. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Eng J Med. 1996;334:1349 –1355.

    Article  CAS  Google Scholar 

  38. Australia/New Zealand Heart Failure Research Collaborative Group. Randomized, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease. Lancet. 1997;349:375–380.

    Google Scholar 

  39. Pfeffer MA, Braunwald E, Moye LA, et al, on behalf of the SAVE Investigators. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: Results of the Survival and Ventricular Enlargement Trial. N Engl J Med. 1992;327:669 –677.

    Article  PubMed  CAS  Google Scholar 

  40. The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327:685– 691.

    Google Scholar 

  41. Westaby S, Coats AFS. Mechanical bridge to recovery. Eur Heart J. 1998;19:541–547.

    Article  PubMed  CAS  Google Scholar 

  42. Schmid C, Hammel D, Deng MC, et al. Ambulatory care of patients with left ventricular assist devices. Circulation. 1999;100(suppl. II):II-224-II-228.

    CAS  Google Scholar 

  43. Mueller J, Wallukut G, Weng YG, et al. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation. 1997;95:542–549.

    Google Scholar 

  44. Schmid C, Weyand M, Hammel D, Deng MC, Nabavi D, Scheld HH. Cerebral and systemic embolization during left ventricular support with the Novacor N100 device. Ann Thorac Surg. 1998;65:1703– 1710.

    Article  PubMed  CAS  Google Scholar 

  45. Levin H, Chen J, Oz M, et al. Potential for left ventricular assist devices as outpatient therapy with awaiting transplantation. Ann Thorac Surg. 1994;58:1515–1520.

    Article  PubMed  CAS  Google Scholar 

  46. Pette D, Smith ME, Staudte HW, et al. Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles. Pfluegers Arch. 1973;338:257–261.

    Article  CAS  Google Scholar 

  47. Chachques JC, Grandjean PA, Carpentier A. Dynamic cardiomyoplasty: Experimental cardiac wall replacement with a stimulated skeletal muscle. In: Chiu RC-J ed. Bio-mechanical Cardiac Assist: Cardiomyoplasty and Muscle-Powered Devices. Mt Kisco, NY: Futura Publsishin Co; 1986:59–84.

    Google Scholar 

  48. Chiu RC-J, Walsh GL, Dewar ML, et al. Implantable extra-aortic balloon assist powered by transformed fatigue-resistant skeletal muscle. J Thorac Cardiovasc Surg. 1987;94:694–698.

    PubMed  CAS  Google Scholar 

  49. Magovern JA, Furnary AP, Christlieb IY, Kao RL, Park SB, Magovern GJ. Indications and risk analysis for clinical cardiomyoplasty. Seminars in Thoracic & Cardiovascular Surgery. 1991;3(2):145–148.

    CAS  Google Scholar 

  50. Young JB, Kirklin JB. Cardiomyoplasty-Skeletal Muscle Assist Randomized Trial (C-SMART): 6 month results. Circulation. 1999;100[18(suppl. I)]:514.

    Google Scholar 

  51. Bolling SF, Deeb GM, Brunsting LA, et al. Early outcome of mitral valve reconstruction in patients with end-stage cardiomyopathy. J Thorac Cardiovasc Surg. 1995;104:676–683.

    Google Scholar 

  52. Bishay ES, McCarthy PM, Cosgrove DM, et al. Mitral valve surgery in patients with severe left ventricular dysfunction. Eur J Cardiothorac Surg. 2000;17:213–221.

    Article  PubMed  CAS  Google Scholar 

  53. Batista RJV, Nery P, Bocchino L, et al. Partial left ventriculectomy to treat end stage heart disease. Ann Thorac Surg. 1997;64:634–638.

    Article  PubMed  CAS  Google Scholar 

  54. Dowling RD, Koenig SC, Ewert DL, Cerrito P, Laureao MA, Gray LA. Does partial left ventriculectomy improve left ventricular systolic and diastolic function? Circulation. 1999;100[18(suppl. 1)]:801.

    Google Scholar 

  55. Starling RC, McCarthy PM, Hoercher KJ, Buda T, Goormastic M, Young JB. Partial left ventriculectomy for dilated cardiomyopathy: A viable option for end-stage heart failure? Circulation. 1999;100[18(suppl. 1)]:801.

    Google Scholar 

  56. Reddy SB, Cooley DA, Duncan JM, et al. Left ventricular aneurysm : Twenty-year surgical experience with 1572 patients at the Texas Heart Institute. Cardiovasc Dis Bull Tex Heart Inst. 1981;11:165–186.

    Google Scholar 

  57. Kesler KA, Fiore AC, Naunheim KS. Anterior wall ventricular aneurysm repair: A comparison of linear versus circular closure. J Thorac Cardiovasc Surg. 1992;103:841–848.

    PubMed  CAS  Google Scholar 

  58. Jatene AD. Surgical treatment of left ventricular aneurysm. In: Baue AE, Geha AS, Hammond GL, Laks H, Naunheim KS eds. Glenns's Thoracic & Cardiovascular Surgery. Vol. 2. 5th ed. Norwalk, CT: Appleton & Lange; 1991:1829–1836.

    Google Scholar 

  59. DiDonato M, Dor V, Sabatier M, et al. Outcome of left ventricular aneurysmectomy with patch repair in patients with severely depressed pump function. Am J Cardiol. 1995;76:557–561.

    Article  CAS  Google Scholar 

  60. Cox JL. Surgical management of left ventricular aneurysms by the Jatene technique. In: Cox JL, Sundt TL, eds. Operative Techniques in Cardiac & Thoracic Surgery—A Comparative Atlas. Vol. 2. WB Saunders, Elsevier Publishing, Orlando FL; 1997:132–138.

    Google Scholar 

  61. Dor V. Sabatier M, DiDonato M, et al. Late hemody-namic results after left ventricular patch repair associated with coronary grafting in patients with post-infarction akinetic or dyskinetic aneurysm of the left ventricle. J Thorac Cardiovasc Surg. 1995;110:1291–1301.

    Article  PubMed  CAS  Google Scholar 

  62. Dor V. Reconstructive left ventricular surgery for post-ischemic akinetic dilatation. Semin Thorac Cardiovasc Surg. 1997;9(2):139–145.

    PubMed  CAS  Google Scholar 

  63. Klein M, Herman M, Gorlin R. A hemodynamic study of left ventricular aneurysms. Circulation. 1967;35:614–630.

    PubMed  CAS  Google Scholar 

  64. Dor V. The treatment of refractory ischemic ventricular tachycardia by endo-ventricular patch plasty reconstruction of the left ventricle. Semin Thorac Cardiovasc Surg. 1997;9(2):146–155.

    PubMed  CAS  Google Scholar 

  65. Judd RM, Kim RJ, Chen E-L, et al. Contrast enhanced magnetic resonance imaging defines the pre- operative location and extent of myocardial scar prior to the Dor procedure. Circulation. 1999;100[18(suppl. 1)]:798.

    Google Scholar 

  66. Buckberg GD. Defining the relationship between akinesia and dyskinesia and the cause of left ventricular failure after anterior infarction and reversal of remodelling to restoration. J Thorac Cardiovasc Surg. 1998;116:47–49.

    Article  PubMed  CAS  Google Scholar 

  67. Raman J, Dixit A, Storer M, Hare DL, Buxton BF. Geometric endo-ventricular patch repair of inferior left ventricular scars improves mitral regurgitation and clinical outcome. Ann Thorac Surg. 2001;72:1055 –1058.

    Article  Google Scholar 

  68. Dabol R, Edwards NM. Cardiac transplantation and other therapeutic options in the treatment of end-stage heart disease. Compr Ther. 2000;26: 109–113.

    Article  PubMed  CAS  Google Scholar 

  69. Krum H, on behalf of the National Heart Foundation of Australia Chronic Heart Failure Clinical Practice Guidelines Writing Panel. Guidelines for management of patients with chronic heart failure in Australia. Med J Aust. 2001;174:459–466.

    PubMed  CAS  Google Scholar 

  70. Barold SS. Biventricular cardiac pacing: Promising new therapy for congestive heart failure. Chest. 2000;118:1812–1819.

    Article  Google Scholar 

  71. Hauer RN, Aliot E, Block M, et al. Indications for implantable cardioverter-defibrillator (ICD) therapy. Study Group on Guidelines on ICDs of the Working Group on arrhythmias of European society of cardiology. Eur Heart J. 2001;22:1074–1081.

    Article  PubMed  CAS  Google Scholar 

  72. Adamopoulos S, Coats A, Brunotte F, et al. Physical training imprives skeletal muscle metabolism in chronic heart failure. J Am Coll Cardiol. 1993;21:1101–1106.

    Article  PubMed  CAS  Google Scholar 

  73. Hare DL, Ryan TM, Selig SE, Pellizzer A, Wrigley T V, Krum H. Resistance exercise training increases muscle strength, endurance and blood flow in patients with chronic heart failure. Am J Cardiol. 1999;83:1674–1677.

    Article  PubMed  CAS  Google Scholar 

  74. McKelvie RS, Mccartney N, Tomlinson C, Baier R, MacDougall JD. Comparison of hemodynamic responses to cycling and resistance exercise in congestive heart failure secondary to ischemic car-diomyopathy. Am J Cardiol. 1995;76:977–979.

    Article  PubMed  CAS  Google Scholar 

  75. Honig B, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation. 1996;93:210–214.

    Google Scholar 

  76. Katz SD, Yuen J, Bijou R, LeJemtel TH. Training improves endothelium-dependent vasodilatation in resistance vessels of patients with heart failure. J Appl Physiol. 1997;82:1488–1492.

    Article  PubMed  CAS  Google Scholar 

  77. Copuya ER, Gerber RS, Drinkwater DJ, et al. Girdling effects of non-stimulated cardiomyo-plasty on left ventricular function. Ann Thorac Surg 1993;56:867– 870.

    Article  Google Scholar 

  78. Patel HJ, Polidori DJ, Pila JJ, et al. Stabilisation of chronic remodelling by asynchronous cardiomyoplasty in dilated cardiomyopathy: Effects of a conditioned muscle wrap. Circulation. 1997;96:3665–3671.

    PubMed  CAS  Google Scholar 

  79. Vaynbalt M, Chiavarelli M, Shah HR, et al. Cardiac binding in experimental heart failure. Ann Thorac Surg. 1997;64:81–85.

    Article  Google Scholar 

  80. Raman J, Power JM, Buxton BF. Ventricular containment as an adjunct to conventional cardiac surgery. Ann Thorac Surg. 2000;70:1124–1126.

    Article  PubMed  CAS  Google Scholar 

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Gupta, M.P., Raman, J. (2008). Pathophysiology—Clinical Spectrum and Current Management. In: Raman, J. (eds) Management of Heart Failure. Springer, London. https://doi.org/10.1007/978-1-84800-104-6_2

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