Clinical Pharmacokinetics: Applications in Pediatric Practice
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The statement “Children are not little adults” is a foundation of pediatric drug therapy referring to well-documented differences in pharmacokinetics and pharmacodynamics existing between children and adults. It is, therefore, important to understand the influence of age on drug disposition, especially in neonates and infants, and resulting effects on drug activity. This chapter provides brief discussions of principles of pediatric pharmacokinetics and knowledge of the effects of disease states on disposition of cardiovascular drugs affecting safe and effective drug therapy.
KeywordsContinuous Renal Replacement Therapy Hepatic Blood Flow Total Body Water Cardiovascular Drug Pediatric Practice
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- 2.Pal VB, Nahata MC. Drug Dosing in Pediatric Patients. In: Murphy JE, ed. Clinical Pharmacokinetics, 2nd ed. Bethesda, MD: American Society of Health-System Pharmacists, Inc, pp. 439–465, 2001.Google Scholar
- 15.Stump AL, Mayo T, Blum A. Management of grapefruit-drug interactions. Amer Family Physicians 2006;74:605–608.Google Scholar