During the past two decades, there has been a great increase in our understanding of the patho-physiology of sepsis and septic shock. This has revealed numerous potential therapeutic targets and major advances in cell and molecular biology have enabled basic scientists to synthesize a large array of new compounds and agents with a potential role in the treatment of sepsis. Using the approach outlined in Table 12.1, this chapter discusses the research basis of major clinical trials in sepsis, the evidence base for sepsis management, and highlights major issues that require further background work and clinical trials to resolve.
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Curtis, H.J., Harmar, A. (2008). Randomized Controlled Trials in Sepsis. In: Baudouin, S.V. (eds) Sepsis. Competency-Based Critical Care. Springer, London. https://doi.org/10.1007/978-1-84628-939-2_12
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