Advertisement

Drug-Induced Renal Injury

  • Sara Blakeley
Part of the Competency-Based Critical Care book series (CBCC)

Abstract

Drug-induced nephrotoxicity contributes to 8 to 60% of all cases of in-hospital acute kidney injury (AKI) and 1 to 23% of cases of AKI seen on the intensive care unit (ICU) (1). The wide variations are caused by different definitions of AKI and different patient populations. Drug-induced nephropathies are often underdiagnosed, and should be considered in every type of renal failure, both acute renal failure and chronic renal failure (CRF).

Keywords

Acute Kidney Injury Atrial Natriuretic Peptide Renal Prostaglandin Ammatory Drug Axis Strategy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schetz M, Dasta J, Goldstein S, Golper T. Druginduced acute kidney injury. Curr Opin Crit Care. 2005;11:555–565.CrossRefPubMedGoogle Scholar
  2. 2.
    Loboz KK, Shenfield GM. Drug combinations and impaired renal function-the “triple whammy”. Br J Clin Pharm. 2005;59(2):239–243.CrossRefGoogle Scholar
  3. 3.
    Perazella MA. Drug induced renal failure: Update on new medications and unique mechanisms of nephrotoxicity. Am J Med Sci. 2003;325(6):349–362.CrossRefPubMedGoogle Scholar
  4. 4.
    Perez Gutthann S, Garcia Rodriguez LA, Raiford DS, et al. Nonsteroidal anti-inflammatory drugs and the risk of hospitalization for acute renal failure. Arch Intern Med. 1996;156:2433–2439.CrossRefPubMedGoogle Scholar
  5. 5.
    Griffin MR, Yared A, Ray WA. Nonsteroidal anti-inflammatory drugs and acute renal failure in elderly persons. Am J Epidemiol. 2000;151:488–496.PubMedGoogle Scholar
  6. 6.
    Barkin RL, Buvanendran A. Focus on the COX-1 and COX-2 agents: Renal effects of nonsteroidal and anti-inflammatory drugs—NSAIDs. Am J Therapeutics. 2004;11:124–129.CrossRefGoogle Scholar
  7. 7.
    Gambaro G, Perazella MA. Adverse renal effects of anti inflammatory agents: Evaluation of selective and non selective cyclooxygenase inhibitors. J Int Med. 2003;253:643–652.CrossRefGoogle Scholar
  8. 8.
    Palmer BF. Renal dysfunction complicating treatment of hypertension. N Engl J Med. 2002;347:1256–1261.CrossRefPubMedGoogle Scholar
  9. 9.
    Beauchamp D, Labrecque G. Aminoglycoside nephrotoxicity: Do time and frequency of administration matter? Curr Opin Crit Care. 2001;7:401–408.CrossRefPubMedGoogle Scholar
  10. 10.
    Nash K, Hafeez A, Hou S. Hospital-acquired renal insufficiency. Am J Kidney Dis. 2002;39(5):930–936.CrossRefPubMedGoogle Scholar
  11. 11.
    Levy EM, Viscoli CM, Horwitz RI. The effect of acute renal failure on mortality. A cohort analysis. JAMA. 1996;275(19):1489–1494.CrossRefPubMedGoogle Scholar
  12. 12.
    Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Contrast-media associated nephrotoxicity. Semin Nephrol. 1997;17:15–26.PubMedGoogle Scholar
  13. 13.
    Rich MW, Crecelius CA. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older. A prospective study. Arch Intern Med. 1990;150(6):1237–1242.CrossRefPubMedGoogle Scholar
  14. 14.
    Manske CL, Sprafka JM, Strony JT, Wang Y. Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography. Am J Med. 1990;89(5):615–620.CrossRefPubMedGoogle Scholar
  15. 15.
    Merten GJ, Burgess WP, Gray LV, et al. Prevention of contrast induced nephropathy with sodium bicarbonate: a randomised controlled trial. JAMA. 2004;291:2328–2334.CrossRefPubMedGoogle Scholar
  16. 16.
    Pannu N, Manns B, Lee H, Tonelli M. Systematic review of the impact of N-acetylcysteine on contrast nephropathy. Kidney Int. 2004;65:1366–1374.CrossRefPubMedGoogle Scholar
  17. 17.
    Aspelin P, Aubry P, Fransson SG, Strasser R, Willenbrock R, Berg KJ. Nephrotoxicity in high-risk patients study of iso-osmolar and low-osmolar non-ionic contrast media study investigators. Nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med. 2003;348(6):491–499.CrossRefPubMedGoogle Scholar
  18. 18.
    Maeder M, Klein M, Fehr T, Rickli H. Contrast nephropathy: Review focusing on prevention. J Am Coll Cardiol. 2004;44:1763–1771.CrossRefPubMedGoogle Scholar
  19. 19.
    Pannu N, Wiebe N, Tonelli M. Prophylaxis strategies for contrast nephropathy. JAMA. 2006;295:2765–2779.CrossRefPubMedGoogle Scholar
  20. 20.
    Cruz DN, Perazella MA, Bellomo R, Corradi V, de Cal M, Kuang D, Ocampo C, Nalesso F, Ronco C. Extracorporeal blood purification therapies for prevention of radiocontrast-induced nephropathy: a systematic review. Am J Kidney Dis. 2006;48(3):361–367.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2008

Authors and Affiliations

  • Sara Blakeley
    • 1
  1. 1.Queen Alexandra HospitalPortsmouth, HampshireUK

Personalised recommendations