The concept of the metabolic syndrome has existed for at least 80 years. In 1920, Kylin, a Swedish physician, first described a constellation of metabolic disturbance, which entailed the risk factors of cardiovascular disease (CVD), atherosclerotic cardiovascular disease (ASCVD), and the clustering of hypertension, hyperglycemia, and gout [1]. In 1988, Reaven [2] postulated that several risk factors—dyslipidemia, hyperglycemia, and hypertension— commonly cluster together, which he recognized as the multiple risk factors for CVD, which he called syndrome X.
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(2008). Introduction. In: The Metabolic Syndrome in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-84628-911-8_1
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