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Meningiomas and Epilepsy

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Meningiomas

Seizures have been recognized for over a century as a symptom of primary and secondary intracerebral tumors.1,2 These seizures may be very distressing to the patient and resistant to various antiepileptic medications.3 To date there is a lack of understanding of the pathophysiological, molecular, and cellular mechanisms of tumor-induced epileptogenicity. Some of the previously suggested mechanisms for tumor-induced epilep-togenicity include focal cortical hypoxia, direct mass effect, peritumor brain edema, perilesional cortical architectural, and cellular disorganizations,4 and altered levels of excitatory amino acids (increased extracellular glutamate secondary to decreased glial-based clearance mechanisms).5,6 Epilepsy could be the final common neurophysiological pathway in the course of development of various types of lesions (including tumors) that affect the cortical structures (either neocortex or archicortex). Seizures are often the first symptom of intracranial tumor, including meningiomas.1 Epilepsy may predate the appearance of other neurologic symptoms or tumor diagnosis by many years.1,7 In this chapter, the incidence, prognosis, and influencing factors in the expression of epilepsy in association with meningiomas will be discussed.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery & Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA

    Jorge A. González-Martínez

  2. Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA

    Imad M. Najm

Authors
  1. Jorge A. González-Martínez
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  2. Imad M. Najm
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Editor information

Editors and Affiliations

  1. Brain Tumor & Neuro-Oncology Center, Department of Neurosurgery, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    Joung H. Lee

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© 2009 Springer-Verlag London Limited

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González-Martínez, J.A., Najm, I.M. (2009). Meningiomas and Epilepsy. In: Lee, J.H. (eds) Meningiomas. Springer, London. https://doi.org/10.1007/978-1-84628-784-8_23

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  • DOI: https://doi.org/10.1007/978-1-84628-784-8_23

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-910-7

  • Online ISBN: 978-1-84628-784-8

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