Iatrogenic Disease

  • Allan G. Howatson

Iatrogenic injury is a feature of all medical practice but it is perhaps nowhere more accepted as an unavoidable consequence of therapy than in obstetric and neonatal medicine. Classical obstetric iatrogenic pathology has been with us since time immemorial, and despite the recognition of causal factors remains a not infrequent occurrence (Ennis and Vincent 1990; CESDI Fifth, Sixth, Seventh and Eighth Reports 1998—2001, www.

The development of invasive antenatal investigation and treatment and the increasingly complex interventions in neonatology have resulted in the appearance of new types and patterns of pathology.


Obstet Gynecol Patent Ductus Arteriosus Chronic Lung Disease Bronchopulmonary Dysplasia Shoulder Dystocia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abu-Osba (1991) Treatment of persistent pulmonary hypertension of the newborn: update. Arch Dis Child 66:74–76.PubMedCrossRefGoogle Scholar
  2. Acker DB, Sachs BP, Friedman EA (1985) Risk factors for shoulder dystocia. Obstet Gynecol 66:762–768.PubMedGoogle Scholar
  3. Aggarwal V, Prakash C, Yadav J, Chattopadhya D (1997) Prevalence of transfusion associated infections in multitransfused children in relation to mandatory screeing of HIV in donated blood. Southeast Asian Journal of Tropical Medicine and Public Health 28:699–706.PubMedGoogle Scholar
  4. Albersheim SG, Solimano AJ, Sharma AK, Smyth JA, Rotschjild A, Wood BJ. (1989) Randomized double blind controlled trial of long term diuretic therapy for bronchopulmonary dysplasia. J Pediatr 115:615–620.PubMedCrossRefGoogle Scholar
  5. Alexander JM, Lucas MJ, Ramin SM, McIntire DD, Leveno KJ (1998) The course of labor with and without epidural anaesthesia. Am J Obstet Gynecol 178:516–520.PubMedCrossRefGoogle Scholar
  6. Alfiveric Z (2000) Early amniocentesis versus transab-dominal villus sampling for prenatal diagnosis. Cochraner Database Syst Review CD000077.Google Scholar
  7. Alfirevic Z, Gosden CM, Neilson JP (2000) Chorion villus sampling versus amniocentesis for prenatal diagnosis. Cochrane Database Syst Rev CD000055.Google Scholar
  8. Anderson KC, Weinstein HJ (1990) Prevention of transfusion-associated graft-vs-host disease. N Engl J Med 323:315–321.PubMedGoogle Scholar
  9. Andrews AF, Nixon CA, Cilley RE, Roloff DW, Bartlett RH (1986) One- to three-year outcome for 14 neonatal survivors of extracorporeal membrane oxygen-ation. Pediatrics 78:692–698.PubMedGoogle Scholar
  10. Andrews AF, Klein MD, Toomasian JM (1983) Venove-nous ECMO in neonates with respiratory failure. J Ped Surg 18:339–346.CrossRefGoogle Scholar
  11. Arya H, Williams J, Ponsford SN, Bissenden JG (1991) Neonatal diaphragmatic paralysis caused by chest drains. Arch Dis Child 66:441–442.PubMedCrossRefGoogle Scholar
  12. Assel B, Lewis D, Dickerman L, Park V, Jassani M (1992) Single operator comparison of early and mid-second trimester amniocentesis. Obstet Gynecol 76:940–944.Google Scholar
  13. Atkinson HC, Begg BH, Darlow BA (1988) Drugs in breast milk. Clin Pharmacokinetics 14:217–240.CrossRefGoogle Scholar
  14. Ayalon A, Anner H, Moghilnen M, Schiller M (1979) Eventration of the diaphragm: a compliction of chest tube placement in neonatal pneumothorax. J Ped Surg 14:474–474.CrossRefGoogle Scholar
  15. Bahrami KR, van Meurs KP (2005) ECMO for neonatal respiratory failure. Semin Perinatol 29:15–23.PubMedCrossRefGoogle Scholar
  16. Balistreri WF, Bove KE (1990) Hepatobiliary consequences of parenteral nutrition. In: Popper H, Schaffner F, (eds) Progress in Liver Diseases, vol IX. Philadelphia: WM Saunders, pp. 567–601.Google Scholar
  17. Barnes ND, Glover WJ, Hull D, Milner AD (1969) Effects of prolonged positive pressure ventilation in infancy. Lancet ii:1096–1099.CrossRefGoogle Scholar
  18. Barr M, Cohen MM (1991) ACE inhibitor fetopathy and hypocalvaria: the kidney-skull connection. Teratology 44:485–495.PubMedCrossRefGoogle Scholar
  19. Barson AJ, Chiswick ML, Doig CM (1978) Fat embolism in infancy after intravenous fat infusions. Arch Dis Child 53:218–223.PubMedCrossRefGoogle Scholar
  20. Bartlett RH, Andrews AF, Toomasian JM Haiduc NJ, Gazzaniga AB (1982) Extracorporeal membrane oxy-genation for newborn respiratory failure, 45 cases. Surgery 92:425–433.PubMedGoogle Scholar
  21. Beall MH, Ross MG (2001) Clavicle fracture in labor: risk factors and associated morbidities. J Perinatol 21:513–515.PubMedCrossRefGoogle Scholar
  22. Becker JA, Short BL, Martin GR (1998) Cardiovascular complications adversely affect survival during extra-corporeal membrane oxygenation. Crit Care Med 26:1582–1586.PubMedCrossRefGoogle Scholar
  23. Becker MH, Genieser ND, Finegold M, Miranda D, Spackman T (1975) Chondrodysplasia punctata. Is maternal warfarin a factor? Am J Dis Child 129:356–359.PubMedGoogle Scholar
  24. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothe-lial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620–1624.PubMedCrossRefGoogle Scholar
  25. Benaron DA (1993) Subgaleal haematoma causing hypovolaemic shock during delivery after failed vacuum extraction: a case report. J Perinatol 13:228–231.PubMedGoogle Scholar
  26. Benjamin D (1981) Hepatobiliary dysfunction in infants and children associated with long-term total paren-teral nutrition. A clinicopathologic study. Am J Clin Pathol 76:276–283.PubMedGoogle Scholar
  27. Berg TE, Pagtaklan RD, Reed MH, Langston C, Chernick V (1975) Bronchopulmonary dysplasia and lung rupture in hyaline membrane disease: influence of continuous distending pressure. Pediatrics 55:51–53.PubMedGoogle Scholar
  28. Berger JT, Gilhooly J (1993) Fibrin glue treatment of persistent pneumothorax in a premature infant. J Pediatr 122:958–960.PubMedGoogle Scholar
  29. Berkowitz GS (1981) An epidemiologic study of preterm delivery. Am J Epidemiol 113:81–92.PubMedGoogle Scholar
  30. Bland RD (2005) Neonatal chronic lung disease in the post-surfactant era. Biol Neonate 88(3):181–191.PubMedCrossRefGoogle Scholar
  31. Bofill JA, Rust OA, Devidus, Roberts WE, Morrison JC Martin JN (1997). Neonatal cephalohaema-toma from vacuum extraction. J Reprod Med 42:565–569.PubMedGoogle Scholar
  32. Bonikos DS, Bensch KG, Northway WH (1976) Oxygen toxicity in the newborn. The effect of chronic continuous 100 per cent oxygen exposure on the lungs of newborn mice. Am J Pathol 85:623–650.PubMedGoogle Scholar
  33. Boros SJ, Mammel MC, Coleman JM, et al. (1985) Neonatal high-frequency jet ventilation: four years experience. Pediatrics 75:657–663.PubMedGoogle Scholar
  34. Bowden RA (1995) Transfusion transmitted cytomega-lovirus infection. Hematol Oncol Clin North Am 9:155–166.PubMedGoogle Scholar
  35. Bowen FW, Chandra R, Avery GB (1973) Pulmonary interstitial emphysema with gas embolism in hyaline membrane disease. Am J Dis Child 126:117– 118.PubMedGoogle Scholar
  36. Brambati B, Tului L (2005) Chorionic villus sampling and amniocentesis. Curr Opin Obstet Gynecol 17:197–201.PubMedCrossRefGoogle Scholar
  37. Brambati B, Oldrini A, Ferrazzi E, Lanzani A (1987) Chorionic villus sampling: an analysis of the obstetric experience of 1000 cases. Prenat Diagn 7:157–169.PubMedCrossRefGoogle Scholar
  38. Brambati B, Terzian E, Tognoni G (1991) Randomized clinical trial of transabdominal versus transcervical chorionic villus sampling methods. Prenat Diagn 11:285–294.PubMedCrossRefGoogle Scholar
  39. Brambati B, Simoni G, Travi M, et al. (1992) Genetic diagnosis by chorinic villus sampling before 8 gestational weeks: efficiency, reliability, and risks on 317 completed pregnancies. Prenat Diagn 12:789– 799.PubMedCrossRefGoogle Scholar
  40. Brand PL, van Lingen RA, Brus F, Talsma MD, Elzenga NJ (1993) Hypertrophic obstructive cardiomyopathy as a side effect of dexamethasone treatment for bron-chopulmonary dysplasia. Acta Pediatrica 82:614– 617.CrossRefGoogle Scholar
  41. Brent RL, Beckman DA (1992) Principles of teratology. In: Evans MI (ed) Reproductive risks and prenatal diagnosis. Norwalk, Connecticut: Appleton & Lange, pp. 43–68.Google Scholar
  42. Brown ER (1979) Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosus. J Pediatr 95:865–866.PubMedCrossRefGoogle Scholar
  43. Brownlee KG, Ng PC, Henderson MJ, Smith M, Green JH, Dear PRF (1992) Catabolic effect of dexametha-sone in the preterm baby. Arch Dis Child 67:1–4.PubMedCrossRefGoogle Scholar
  44. Brubaker DB (1986) Transfusion-associated graft-versus-host disease. Hum Pathol 17:1085–1088.PubMedCrossRefGoogle Scholar
  45. Buehler BA, Delimont D, van Waes M, Finnell RH (1990) Prenatal prediction of risk of the fetal hydan-toin syndrome. N Engl J Med 322:1567–1572.PubMedGoogle Scholar
  46. Bulas D, Glass P (2005) Neonatal ECMO: neuroimaging and neurodevelopmental outcomes. Semin Perinatol 29:58–65.PubMedCrossRefGoogle Scholar
  47. Burton BK, Schulz CJ, Baird PA (1989) Limb anomalies associated with chorionic villus sampling. Obstet Gynecol 79:726–730.Google Scholar
  48. Butters L, Kennedy S, Rubin P (1990) Atenolol in essential hypertension during pregnancy. Br Med J 301:587–589.CrossRefGoogle Scholar
  49. Canadian Collaborative CVS-Amniocentesis Clinical Trial Group (1989) Multicentre randomized clinical trial of chorion villus sampling and amniocentesis. Lancet i:1–6.Google Scholar
  50. Carillo P (1985) Palatal groove formation and oral endotracheal intubation. Am J Dis Child 139:859– 880.Google Scholar
  51. Cartlidge PH, Fox PE, Rutter N (1990) The scars of newborn intensive care. Early Hum Dev 21:1–10.PubMedCrossRefGoogle Scholar
  52. Cass DL (2005) Fetal surgery for congenital diaphragmatic hernia: the North American experience. Semin Perinatol 29:104–111.PubMedCrossRefGoogle Scholar
  53. Castillo M, Fordham LA (1995) MR of neurologically symptomatic newborns after vacuum extractino delivery. Am J Neuroradiol 16:816–818.PubMedGoogle Scholar
  54. Chamberland ME, Epstein J, Dodd RY, Persin D, Will RG, De Maria A, Emmanuel JC, Pierce B, Khabbaz R (1998) Blood safety. Emerging Infectious Diseases 4:410–411.PubMedGoogle Scholar
  55. Chan KN, Chakrabarti MK, Whitwam JG, Silverman M (1988) Assessment of a new valveless infant ventilator. Arch Dis Child 63:162–167.PubMedCrossRefGoogle Scholar
  56. Chida S, Phelps DS, Soll RF, Taeusch HW (1991) Surfactant proteins and anti-surfactant antibodies in sera from infants with respiratory distress syndrome with and without treatment. Pediatrics 88:84–89.PubMedGoogle Scholar
  57. Chiu CJ, Golding MR, Linder JB, Fries CC (1967) Pulmonary venous air embolism: a haemodynaemic reappraisal. Surgery 61:816–819.PubMedGoogle Scholar
  58. Chiswick ML, Milner RDG (1976) Crying vital capacity measurement of neonatal lung function. Arch Dis Child 51:22–27.PubMedCrossRefGoogle Scholar
  59. Chudley AE, Brown DR, Holzman IR, Oh KS (1980) Nutritional rickets in two very low birth weight infants with chronic lung disease. Arch Dis Child 55:687–690.PubMedCrossRefGoogle Scholar
  60. Cifuentes RF, Olley PM, Balfe JW, Radde IC, Soldin SJ (1979) Indomethacin and renal function in premature infants with persistent ductus arteriosus. J Pediatr 95:583–587.PubMedCrossRefGoogle Scholar
  61. Clark RH (1999) Support of gas exchange in the delivery room and beyond: how do we avoid hurting the baby we seek to save? Clin Perinatol 26:669–681.PubMedGoogle Scholar
  62. Clarke TA, Coen RW, Feldman B, Papile L (1980) Eosophageal perforations in premature infants and comments on diagnosis. Am J Dis Child 134:367– 368.PubMedGoogle Scholar
  63. Cohen AW, Otto SR (1980) Obstetric clavicular fractures. J Reprod Med 25:119.PubMedGoogle Scholar
  64. Cohen C, Olsen MM (1981) Pediatric total parenteral nutrition. Arch Pathol Lab Med 105:152–156.PubMedGoogle Scholar
  65. Collaborative Dexamethasone Trial Group (1991) Dexamethasone therapy in neonatal lung disease: an international placebo-controlled trial. Pediatrics 88:421–427.Google Scholar
  66. Confidential Enquiry into Stillbirths and deaths in Infancy (CESDI) 5th Annual Report (1998). Maternal and Child Health Research Consortium, London.Google Scholar
  67. Confidential Enquiry into Stillbirths and deaths in Infancy (CESDI) 6th Annual Report (1999). Maternal and Child Health Research Consortium, London.Google Scholar
  68. Confidential Enquiry into Stillbirths and deaths in Infancy (CESDI) 7th Annual Report (2000). Maternal and Child Health Research Consortium, London.Google Scholar
  69. Confidential Enquiry into Stillbirths and deaths in Infancy (CESDI) 7th Annual Report (2001). Maternal and Child Health Research Consortium, London.Google Scholar
  70. Cooke RWI (1991) Factors associated with chronic lung disease in preterm infants. Arch Dis Child 66:776–779.PubMedCrossRefGoogle Scholar
  71. Corazza MS, Davis RF, Merritt TA, Bejar R, Cvetnic W (1984) Prolonged bleeding time in preterm infants receiving indomethacin for patent ductus arteriosus. J. Pediatr 105:292–296.PubMedCrossRefGoogle Scholar
  72. Crapo JD, Peters-Golden M, Marsh-Salin J, Shelburne J (1978) Pathologic changes in the lungs of oxygen-adapted rats. A morphometric analysis. Lab Invest 39:640–653.PubMedGoogle Scholar
  73. Cromblehome TM, Adzick NS, DeLorimier AA, Longaker MT, Harrison MR, Charlton VE (1990) Carotid artery reconstruction following extracorpo-real membrane oxygenation. Am J Dis Child 144:872– 874.Google Scholar
  74. Cromblehome T, Harrison M, Golbus M, et al. (1990) Fetal intervention in obstructive uropathy: prognostic indicators and efficacy of intervention. Am J Obstet Gynecol 162:1239–1244.Google Scholar
  75. Cummings JJ, D'Eugenio DB, Gross SJ (1989) A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. New Engl J Med 320:1505–1510.PubMedGoogle Scholar
  76. Cunniff C, Jones KL, Phillipson J, Benirschke K, Short S, Wujek J (1990) Oligohydramnios sequence and renal malformation associated with maternal enala-pril use. Am J Obstet Gynecol 162:187–189.PubMedGoogle Scholar
  77. Daffos F, Capella Paulovsky M, Forester F (1985) Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: a study of 606 consecutive cases. Am J Obstet Gynecol 153:655–660.PubMedGoogle Scholar
  78. De Lemos RA, Coalson JJ, Gerstmann DR, Kuehl TJ, Null DM (1987) Oxygen toxicity in the premature baboon with hyaline membrane disease. Am Rev Resp Dis 136:677–682.Google Scholar
  79. Demir RH, Gleicher N, Myers SA (1989) Atraumatic antepartum subdural haematoma causing fetal death. Am J Obstet Gynecol 160:619–620.PubMedGoogle Scholar
  80. De Rubertis FR, Michelia MF, Beck N, Davis BB (1970) Complications of diuretic therapy: severe alkalosis and syndrome resembling inappropriate secretion of anti-diuretic hormone. Metabolism 19:709–719.CrossRefGoogle Scholar
  81. Dike AE, Christie JM, Kurtz JB, Teo CG (1998) Hepatitis C in blood transfusion recipients identified at the Oxford Blood Centre in the national HCV look-back programme. Transfusion Med 8:87–95.CrossRefGoogle Scholar
  82. Dmochowski RR, Crandell SS, Corrieri VN (1986) Bladder injury and uroascites from umbilical artery catheterization. Pediatrics 77:421–422.PubMedGoogle Scholar
  83. Dodic M, Peers A, Coghlan JP, Wintour M (1999) Can excess glucocorticoid, in utero, predispose to cardiovascular and metabolic diseases in middle age? Trends Endocrinol Metab 10:86–89.PubMedCrossRefGoogle Scholar
  84. Downing GJ, Hayen LK, Kilbride HW (1993) Acquired subglottic cysts in the low birth-weight infant: characteristics, treatment and outcome. Am J Dis Child 147:971–974.PubMedGoogle Scholar
  85. Drew JH, Landau LI, Acton CM, Kent M, Campbell PE (1978) Pulmonary interstitial emphysema requiring lobectomy. Complication of assisted ventilation. Arch Dis Child 53:424–426.PubMedCrossRefGoogle Scholar
  86. Drucker DEM, Greenfield LJ, Ehrlich F, Salzberg AM (1986) Aorto-iliac aneurysms following umbilical artery catheterization. J Ped Surg 21:725–730.CrossRefGoogle Scholar
  87. Dupuis O, Silveira R, Dupont C, et al. (2005) Comparison of “instrument-associated” and “spontaneous” obstetric depressed skull fractures in a cohort of 68 neonates. Am J Obstet Gynecol 192:165–170.PubMedCrossRefGoogle Scholar
  88. Edwards AD, Wyatt JS, Richardson C, et al. (1990) Effects of indomethacin on cerebral haemodynamics in very preterm infants. Lancet 335:1491–1495.PubMedCrossRefGoogle Scholar
  89. Edwards MJ, Shiota K, Smith MSR, Walsh DA (1995) Hyperthermia and birth defects. Reprod Toxicol 9:411–425.PubMedCrossRefGoogle Scholar
  90. Ehrenkranz RA, Bonta AW, Albow RC, Warshaw JB (1978) Amelioration of bronchopulmonary dysplasia following vitamin E administration. A preliminary report. N Engl J Med 299:564–568.PubMedCrossRefGoogle Scholar
  91. Ellison RC, Peckham GJ, Lang P, et al. (1983) Evaluation of the preterm infant for patent ductus arteriosus. Pediatrics 71:364–372.PubMedGoogle Scholar
  92. Extracorporeal Life Support Organization Registry 1990. Extracorporeal Life Support Organization 9ELSO) Registry. University of Michigan, Ann Arbour, Michigan, February 1990.Google Scholar
  93. Emery EF, Greenough A (1992) Effect of dexametha-sone on blood pressure: relationship to postnatal age. Eur J Pediatr 151:364–366.PubMedCrossRefGoogle Scholar
  94. Emery EF, Greenough A (1992a) Neonatal blood pressure levels of preterm infants who did and did not develop chronic lung disease. Early Hum Devel 31:149–156.CrossRefGoogle Scholar
  95. Emery EF, Greenough A (1992b) Blood pressure levels at follow up of preterm infants with and without chronic lung disease. Pediatr Res 32:620A.CrossRefGoogle Scholar
  96. Ennis M, Vincent CA (1990) Obstetric accidents: a review of 64 cases. Br Med J 300:1365–1367.CrossRefGoogle Scholar
  97. Espinosa H, Paredes CG (1974) Endotracheal injuries traumatic perforation of the pharynx in a newborn baby. J Pediatr Surg 9:247–248.PubMedCrossRefGoogle Scholar
  98. Evans M, Greb A, Kunkel LM, et al. (1991) In utero fetal muscle biopsy for the diagnosis of Duchenne muscular dystrophy. Am J Obstet Gynecol 165:728–732.PubMedGoogle Scholar
  99. European Federation of Societies for Ultrasound in Medicine and Biology (1991) Newsletter No. 5.Google Scholar
  100. Fadavi S, Adeni S, Dziedzic, Punwani I, Vidyasagar D (1992) The oral effects of orotracheal intubation in prematurely born preschoolers. ASDC J Dent Child 59:420–424.PubMedGoogle Scholar
  101. Fanos V, Cataldi L (1999) Antibacterial-induced neph-rotoxicity in the newborn. Drug Saf 20:245–267.PubMedCrossRefGoogle Scholar
  102. Farmer DL (1998) Fetal surgery: a brief review. Pediatr Radiol 28:407–413.CrossRefGoogle Scholar
  103. Faxelius G, Hagenvik K, Lagercrantz H, Lundell B, Ivestedt L (1983) Catecholamine surge and lung function after delivery. Arch Dis Child 58:262– 266.PubMedCrossRefGoogle Scholar
  104. Fearne J, Bryan E, Elliman A (1985) Enamel defects in deciduous dentition of low birth weight infants. Presented to the Paediatric Research Societies in Europe, Munich.Google Scholar
  105. Field DJ, Milner AD, Hopkin IE (1985) Manipulation of ventilator settings to prevent active expiration against positive pressure ventilation. Arch Dis Child 60:1036–40.PubMedCrossRefGoogle Scholar
  106. Field DJ, Milner AD, Hopkin IE, Madeley RJ (1987) Changing patterns in neonatal respiratory disease. Paediatr Pulmonol 3:231–235.CrossRefGoogle Scholar
  107. Finer NN (2004) Surfactant use for neonatal lung injury: beyond respiratory distress syndrome. Pediatr Respir Rev 5(suppl A):S289–297.CrossRefGoogle Scholar
  108. Finnell RH, Chernoff GF (1984) Genetic background: the elusive component in the fetal hydantoid syndrome. Am J Med Genet 19:459–462.PubMedCrossRefGoogle Scholar
  109. Firth HV, Boyd PA, Chamberlain P, MacKenzie IZ, Lindenbaum RH, Huson SM (1991) Severe limb abnormalities after chorionic villus sampling at 56– 66 days gestation. Lancet 337:762–763.PubMedCrossRefGoogle Scholar
  110. Fischer GW, Hunter KW, Wilson SR, Mease AD (1980) Diminished bacterial defences with intralipid. Lancet ii:819–820.CrossRefGoogle Scholar
  111. Florentino-Pineda I, Ezhuthachan SG, Sineni LG, Kumar SP (1994) Subgaleal haemorrhage in the newborn infant associated with silcone elastomer vacuum extractor. J Perinatol 14:95–100.PubMedGoogle Scholar
  112. Fok TF, Ha MH, Leung KW, Wong W (1986) Sciatic nerve palsy complicating umbilical arterial catheter-ization. Eur J Pediatr 145:308–309.PubMedCrossRefGoogle Scholar
  113. Fox WW, Spiler AR, Musci M (1984) Tracheal secretion impaction during hyperventilation for persistent pulmonary hypertension of the neonate. Pediatr Res 18:323A.CrossRefGoogle Scholar
  114. Frank L, Sosenko IRS (1987) Prenatal development of lung antioxidant systems in four species. J Pediatr 110:106–112.PubMedCrossRefGoogle Scholar
  115. Frank L, Sosenko IRS (1991) Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure: increases susceptibility to pulmonary oxygen toxicity compared with term rabbits. Pediatr Res 29:292–296.PubMedGoogle Scholar
  116. Freeman J, Goldman DA, Smith NE, Sidebottom DG, Epstein MF, Platt R (1990) Association of intravenous lipid emulsions and coagulase negative staphy-lococcal bacteremia in neonatal intensive care units. N Engl J Med 323:301–308.PubMedGoogle Scholar
  117. Frewin R, Chisholm M (1998) Anticoagulation of women with prosthetic heart valves during pregnancy. Br J Obstet Gynaecol 105:683–686.PubMedGoogle Scholar
  118. Friedman WF, Fitzpatrick KM (1980) Effects of pro stoglandins, thromboxanes and inhibitors of their synthesis on renal and gastrointestinal function in the newborn period. Sem Perinatol 4:143– 156.Google Scholar
  119. Froster-Iskenius UG, Baird PA (1989) Limb reduction defects in over one million consecutive live births. Teratology 39:127–135.PubMedCrossRefGoogle Scholar
  120. Gamba P, Tchaprassian Z, Verlato G, Orzali A, Zanon GF (1997) Iatrogenic vascular lesions in extremely low birth weight and low birth weight neonates. J Vasc Surg 26:643–646.PubMedCrossRefGoogle Scholar
  121. Gaston B, Drazen JM, Loscalzo J, Stamler JS (1994) The biology of nitrogen oxides in the airways. Am J Resp Crit Care Med 149:538–551.PubMedGoogle Scholar
  122. Gehring JE, Cain MP, Casale AJ, Kaefer M, Rink RC (2000) Abdominal wall hernia: an uncommon complication of in utero vesicoamniotic shunt placement. Urology 56:330.PubMedCrossRefGoogle Scholar
  123. Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS (1983) Effects of indomethacin in premature infants with patent ductus arteriosus. Results of a national collaborative study. J Pediatr 102:895– 906.PubMedCrossRefGoogle Scholar
  124. Gerten KA, Coonrod DSV, Bay RC, Chambliss LR (2005) Cesarian delivery and rds: does labor make a difference. Am J Obstet Gynecol 193:1061–1064.PubMedCrossRefGoogle Scholar
  125. Ghanooni M, Mattison DR, Zhang YP, Macina OT, Rosenkranz JS, Glopman G (1997) Structural determinants associated with risk of human developmental toxicity. Am J Obstet Gynecol 176:799–806.PubMedCrossRefGoogle Scholar
  126. Gherman RB, Ouzounian JG, Goodwin TM (1998) Obstetric maneuvers for shoulder dystocia and associated fetal morbidity. Am J Obstet Gynecol 178:1126–1130.PubMedCrossRefGoogle Scholar
  127. Ginsberg JS, Barron WM (1994) Pregnancy and pros-tehtic heart valves. Lancet 344:1171–1172.CrossRefGoogle Scholar
  128. Glossten B ed (1991) Perinatal Anaesthesia: Sem Perinatol 115 No 5.Google Scholar
  129. Goetzman BW, Stadalnik RC, Bogren HG, Blanknship WJ, Ikeda RM, Thayer J. (1975) Thrombotic complications of umbilical artery catheterization. A clinical and radiological study. Pediatrics 56:374–379.PubMedGoogle Scholar
  130. Gould SJ, Howard S (1985) The histopathology of the larynx in the neonate following endotracheal intubation. J Pathol 146:301–311.PubMedCrossRefGoogle Scholar
  131. Govaert P, Vanhaesebrouck P, De Praeter C, Moens K, Leroy J (1992) Vacuum extraction, bone injury and neonatal subgaleal bleeding. Eur J Pediatr 151:532–535.PubMedCrossRefGoogle Scholar
  132. Gratacos E, Deprest J (2000) Current experience with fetoscopy and the Eurofetus registry for fetoscopic procedures. Eur J Obstet Gynecol Reprod Biol 92:151–159.PubMedCrossRefGoogle Scholar
  133. Graziani LJ, Gringlas M, Baumgart S (1997) Cerebro-vascular complications and neurodevelopmental sequelae of neonatal ECMO. Clinics in Perinatology 24:655–675.PubMedGoogle Scholar
  134. Greenough A, Morley CJ, Davis JA (1983) The interaction of the infant's spontaneous respiration with ventilation. J Pediatr 103:769–773.PubMedCrossRefGoogle Scholar
  135. Greenough A, Wood S, Morley CJ, Davis JA (1984) Pulmonary interstitial emphysema. Arch Dis Child 59:1046–1051.PubMedCrossRefGoogle Scholar
  136. Greenough A, Morley CJ, Pool J (1986) Fighting the ventilator—are fast rates an effective alternative to paralysis? Early Hum Devel 13:189–194.CrossRefGoogle Scholar
  137. Greenough A, Emery EF, Gamsu HR (1992) Dexameth-asone and hypertension in preterm infants. Eur J Pediatr 152:134–135.CrossRefGoogle Scholar
  138. Gresens CJ, Holland PV (1998) Current risk of viral hepatitis from blood. J Gastroenterol Hepatol 13:443–449.PubMedCrossRefGoogle Scholar
  139. Gresik MV (1996) Transfusion-associated graft-versus-host disease. Pediatr Pathol Lab Med 16:137–142.PubMedCrossRefGoogle Scholar
  140. Gunn T, Reece ER, Metrakos K, Cole E (1984) Depressed T cells following neonatal steroid treatment. Pediatrics 67:61–67.Google Scholar
  141. Gunn TR, Becroft DM (1984) Unexplained intracranial haemorrhage in utero: the battered fetus? Aust NZ J Obstet Gynaecol 24:17–22.CrossRefGoogle Scholar
  142. Gupta JM, Roberton NRC, Wigglesworth JS (1968) Umbilical artery catheterization in the newborn. Arch Dis Child 43:382–387.PubMedCrossRefGoogle Scholar
  143. Haddad IY, Ischiropoulous H, Holm BA, Beckman JS, Barker JR, Matalon S (1993) Mechanisms of per-oxynitrite-induced injury to pulmonary surfactants. Am J Physiol 265:555–564.Google Scholar
  144. Haldeman S, Fowler GW, Ashwal S, Schneide S (1983) Acute flaccid neonatal paraplegia. A case report. Neurology 33:93–95.PubMedGoogle Scholar
  145. Hall JG, Paul RM, Wilson KN (1980) Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med 68:122–140.PubMedCrossRefGoogle Scholar
  146. Hall SL (1992) Simultaneous occurrence of intracranial and subgaleal haemorrhages complicating vacuum extraction delivery. J Perinatol 12:185–187.PubMedGoogle Scholar
  147. Hammerman C, Aramburo MJ (1988) Decreased lipid intake reduces morbidity in sick premature infants. J Pediatr 113:1083–1088.PubMedCrossRefGoogle Scholar
  148. Hamutcu R, Nield TA, Garg M, Keens TG, Platzker AC (2004) Long-term pulmonary sequelae in children who were treated with extracorporeal membrane oxygenation for neonatal respiratory failure. Pediatrics 114:12192–1296.CrossRefGoogle Scholar
  149. Hanson F, Tennat F, Hune S, Brooklyser K (1992) Early amniocentesis: outcome risks and technical problems at less than or equal to 12.8 weeks. Am J Obstet Gynecol 166:1707–1711.PubMedGoogle Scholar
  150. Hanson JW, Smith DW, Cohen MM (1976) Prominent lateral palatine ridges: developmental and clinical relevance. J Pediatr 89:54–58.PubMedCrossRefGoogle Scholar
  151. Harpin V, Rutter N (1982) Percutaneous alcohol absorption and skin necrosis in a preterm infant. Arch Dis Child 57:477–479.PubMedCrossRefGoogle Scholar
  152. Harrison MR, Adzick NS, Longaker MT, et al. (1990) Successful repair in utero of a fetal diaphragmatic hernia after removal of herniated viscera from the left thorax. N Engl J Med 322:1582–1584.PubMedGoogle Scholar
  153. Heerema AE, Rabban JT, Sydorak RM, Harrison MR, Jones KD (2003) Lung pathology in patients with congenital diaphragmatic hernia treated with fetal surgical intervention, including tracheal occlusion. Pediatr Dev Pathol 6:536–546.PubMedCrossRefGoogle Scholar
  154. Heffelfinger S, Hawkins EP, Nihill M, Langston C (1987) Pulmonary vascular changes associated with prolonged prostaglandin E1 treatment. Pediatr Pathol 7:165–173.PubMedGoogle Scholar
  155. Hickey K, McKenna P (1996) Skull fracture caused by vacuum extraction. Obstet Gynecol 89:319.CrossRefGoogle Scholar
  156. High-frequency Oscillatory (HiFO) Study Group (1993) Randomised study of high frequency oscillatory ventilation in infants with severe respiratory distress syndrome. J Pediatr 122:606– 619.CrossRefGoogle Scholar
  157. Hill RM, Verniaud WM, Horning MG, McCulley LB, Morgan NF (1974) Infants exposed in utero to anti-epileptic drugs. Am J Dis Child 127:645.PubMedGoogle Scholar
  158. Holcomb GW, Templeton JM (1989) Iatrogenic perforation of the bronchus intermedius in a 1100 g neonate. J Pediatr Surg 24:1132–1134.PubMedCrossRefGoogle Scholar
  159. Hufnagle KG, Khan SN, Penn D, Cacciarelli A, Williams P (1982) Renal calcifications: a complication of long term frusemide therapy in preterm infants. Pediatrics 70:360–363.PubMedGoogle Scholar
  160. Huisman TA, Fischer J, Willi UV, Eich GF, Martin E (1999) “Growing fontanelle”: a serious complication of difficult vacuum extraction. Neuroradiology 41:381–383.PubMedCrossRefGoogle Scholar
  161. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G (1987) Endothelin-derived relaxing factor pro-duced and released from artery and vein is nitric oxide. Proc Natl Acad Sci 84:9265–9269.PubMedCrossRefGoogle Scholar
  162. Jackson LG, Zachary JM, Fowler SE, et al. (1992) A randomized comparison of transcervical and transabdominal chorionic-villus sampling. The US National Institute of Child Health and Human Development Chorionic-Villus Sampling and Amniocen-tesis Study Group. N Engl J Med 327:594–598.PubMedGoogle Scholar
  163. Jauniaux EW, Pahal GS, Rodeck CH (2000) What invasive procedure to use in early pregnancy? Baillieres Best Pract Res Clin Obstet Gynaecol 14:651–652.PubMedCrossRefGoogle Scholar
  164. Johnson L, Bowen FW, Abbasi S, et al. (1985) Relationship of prolonged pharmacologic serum levels of vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1500 grams or less. Pediatrics 75:619–630.PubMedGoogle Scholar
  165. Jonville AP, Autret E, Bavoux F, Bertrand PP, Barbier P, Gauchez AJ (1991) Characteristics of medication errors in paediatrics. Dalian Institute of Chemical Physics—annals of pharmacotherapy 25:1113–1118.Google Scholar
  166. Junker P, Egeblad M, Nielson O, Kamper J (1976) Case report. Umbilical vein catheterizatin and portal hypertension. Acta Paediatr Scand 65:499–504.PubMedCrossRefGoogle Scholar
  167. Kao LC, Warburton D, Sargent CW, Platzker ACG, Keens TG (1983) Furosemide acutely decreases airway resistance in chronic bronchopulmonary dys-plasia. J Pediatr 103:624–629.PubMedCrossRefGoogle Scholar
  168. Kaplan B, Rabinerson D, Averch OM, Carmi N, Steinberg DM, Merlos P (1998) Fracture of the clavicle in the newborn following normal labor and delivery. Int J Gynaecol Obstet 63:15–20.PubMedCrossRefGoogle Scholar
  169. Kempley ST, Gamsu HR (1992) Randomized trial of umbilical arterial catheter position: Doppler ultrasound findings. Arch Dis Child 67:855–859.PubMedCrossRefGoogle Scholar
  170. Khambekar K, Nichani S, Luyt DK, et al. (2006) Developmental outcome in newborn infants treated for acute respiratory failure with ECMO: Present experience. Arch Dis Child Fetal Neonatal Ed. 91:F21–F25.PubMedCrossRefGoogle Scholar
  171. Kinsella JP, Abman SH (1993) Inhalational nitric oxide therapy for persistent pulmonary hypertension of the newborn. Pediatrics 91:997–998.PubMedGoogle Scholar
  172. Kitterman JA, Phibbs RH, Tooley WH (1970) Catheter-ization of umbilical vessels in newborn infants. Pediatr Clin North Am 17:895–912.PubMedGoogle Scholar
  173. Klein MD, Andrews AF, Wesley JR, et al. (1985) Veno-venous perfusion in ECMO for newborn respiratory insufficiency. Ann Surg 201:520–526.PubMedCrossRefGoogle Scholar
  174. Kooy NW, Royall JA, Ye YZ, Kelly DR, Beckman JS (1995) Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Resp Crit Care Med 151:1250–1254.PubMedGoogle Scholar
  175. Koren G, Barzilay Z, Greenwald M (1986) Tenfold errors in administration of drug doses: a neglected iatro-genic disease in pediatrics. Pediatrics 77:848–849.PubMedGoogle Scholar
  176. Kugelman A, Gangitano EW, Taschuk R, et al. (2005) Extracorporeal membrane oxygenation in infants with meconium aspiration syndrome: a decade of experience with venovenous ECMO. J Pediatr Surg 40:1082–1089.PubMedCrossRefGoogle Scholar
  177. Kuliev A, Jackson L, Forster U, et al. (1996) Fetus-Placenta-Newborn: Chorionic villus sampling safety: Report of WHO/EURO meeting in association with the Seventh International Conference on Early Prenatal Diagnosis of Genetic Diseases, Tel-Aviv, Israel May 21, 1994. Am J Obstet Gynecol 174:807–811.PubMedCrossRefGoogle Scholar
  178. Kuliev AM, Modell B, Jackson L, et al. (1993) Risk evaluation of CVS. Prenat Diagn 13:197–209.PubMedCrossRefGoogle Scholar
  179. Kuller J, Golbus MS (1992) Fetal therapy in Prenatal Diagnosis and Screening (eds. D Brock, CH Rodeck, and M Fergson-Smith). Churchill-Livingstone, Edinburgh. pp. 703–717.Google Scholar
  180. Kumar SP, Belik J (1984) Chylothorax—a complication of chest tube placement in a neonate. Crit Care Med 12:411–412.PubMedCrossRefGoogle Scholar
  181. Lammer EJ, Chen DT, Hoar RM, et al. (1985) Retinoic acid embryopthy. N Engl J Med 313:837–841.PubMedGoogle Scholar
  182. Lamb MP (1975) Gangrene of a fetal limb due to amnio-centesis. Br J Obstet Gynaecol 82:829–830.PubMedGoogle Scholar
  183. Larroche JC (1970) Umbilical catheterization: its complications. Biol Neonate 16:101–116.PubMedCrossRefGoogle Scholar
  184. Lauridsen UB, Enk B, Gammeltoft A (1978) Oeso-phageal varcies as a late complication to neonatal umbilical vein catheterization. Acta Paedatr Scand 67:633–636.CrossRefGoogle Scholar
  185. Leck IM, Miller ELM (1962) Incidence of malformations since the introduction of thalidomide. Lancet ii:16–20.Google Scholar
  186. Lee SK, Tanswell AK (1989) Pulmonary vascular air embolism in the newborn. Arch Dis Child 64:507– 510.PubMedCrossRefGoogle Scholar
  187. Lenz W (1962) Thalidomide and congenital abnormalities. Lancet i:45.CrossRefGoogle Scholar
  188. Levine MG, Holroyde J, Woods JR, Siddiqi TA, Scott M, Miodovnik M (1984) Birth trauma: incidence and predisposing factors. Obstet Gynecol 63:792–795.PubMedGoogle Scholar
  189. Lin PH, Dodson TF, Bush RL, et al. (2001) Surgical intervention for complications caused by femoral artery catheterization in pediatric patients. J Vasc Surg 34:1071–1078.PubMedCrossRefGoogle Scholar
  190. Liu H, Chen J-C, Holinger LD, Gonzalez-Crussi F (1995) Histopathologic fundamentals of acquired laryngeal stenosis. Ped Pathol Lab Med 15:655–677.Google Scholar
  191. Low L, Ratcliffe W, Alexander W (1978) Intrauterine hypothyroidism due to antithyroid-drug therapy for thyrotoxicosis during pregnancy. Lancet II:370–371.CrossRefGoogle Scholar
  192. Lowe CA, Tuma RF, Sivieri EM, Schaffer TM (1979) Liquid ventilation: cardiovascular adjustments with secondary hyperlactaemia and acidosis. J Appl Physiol 47:1051–1056.PubMedGoogle Scholar
  193. Lynch TP, Coran Ag, Cohen SR, Lee FA (1974) Traumatic esophageal pseudodiverticula in the newborn. J Pediatr Surg 9:675–680.PubMedCrossRefGoogle Scholar
  194. McLachlan JA (1993) Functional toxicology: a new approach to detect biologically active xenobiotics. Envir Hlth Perspect 101:386–387.CrossRefGoogle Scholar
  195. Macpherson TA, Shen-Schwarz S, Valdes-Dapena M (1988) Prevention and reduction of iatrogenic disorders in the newborn. In: Guthrie R (ed) Clinics in Critical Care Medicine: Recent Advances in Neonatal Intensive Care. Churchill Livingstone, New York, pp. 271–312.Google Scholar
  196. McShane D, Nicholson AG, Goldstraw P, et al. (2002) Inflammatory endobronchial polyps in childhood: clinical spectrum and possible link to mechanical ventilation. Pediat Pulmonol 34:79–84.CrossRefGoogle Scholar
  197. Madansky DL, Lawson EE, Chernick V, Taeusch HW (1979) Pneumothorax and other forms of pulmonary air leak in newborns. Am Rev Resp Dis 120:729–737.PubMedGoogle Scholar
  198. Mammel MC, Boros SJ (1987) Airway damage and mechanical ventilation. Ped Pulmonol 3:443–447.CrossRefGoogle Scholar
  199. Mann NP (1980) Gluteal skin necrosis after umbilical artery catheterization. Arch Dis Child 14:815–817.CrossRefGoogle Scholar
  200. Marinelli PV, Ortiz A, Alden ER (1981) Acquired even-tration of the diaphragm: a complication of chest tube placement in neonatal pneumothorax. Pediatrics 67:552–554.PubMedGoogle Scholar
  201. Marsh JL, King W, Barrett C, Fonkalsrud (1975) Serious complications after umbilical artery catheterization for neonatal monitoring. Arch Surg 110:1203–1208.PubMedGoogle Scholar
  202. Matalon S, De Marco V, Haddad IY, et al. (1996) Inhaled nitric oxide injures the pulmonary surfactant system of lambs in vivo. Am J Phyxiol 270:273–280.Google Scholar
  203. Matthews SG (2000) Antenatal glucocorticoids and programming of the developing CNS. Pediatr Res 47:291–300.PubMedCrossRefGoogle Scholar
  204. Maxwell DJ, Johnson P, Hurley P, Neales K, Allan L, Knott P (1991) Fetal blood sampling and pregnancy loss in relation to indication. Br J Obstet Gynaecol 98:892–897.PubMedGoogle Scholar
  205. Mazzaferri EL (1997) Evaluation and management of common thyroid disorders in women. Am J Obstet Gynecol 176:507–514.PubMedCrossRefGoogle Scholar
  206. McCann EM, Lewis K, Denning DD, Donovan MJ, Brady JP (1985) Controlled trial of frusemide therapy in infants with chronic lung disease. J. Pediatr 106:957–962.PubMedCrossRefGoogle Scholar
  207. Meadow SR (1968) Anticonvulsant drugs and congenital abnormalities. Lancet ii:1296.CrossRefGoogle Scholar
  208. Medda E, Donati S, Spinelli A, Di Renzo GC (2003) Genetic amniocentesis: a risk factor for preterm delivery? Eur J Obstet Gynecol 110:153–158.CrossRefGoogle Scholar
  209. Medical Research Council Working Part on the Evaluation of Chorionic Villus Sampling (1991) Medical Research Council European trial of chorion villus sampling and amniocentesis. Lancet 377:1491–1499.Google Scholar
  210. Merritt CR, Kremkau FW, Hobbins JC (1992) Diagnostic ultrasound: bioeffects and safety. Ultrasound Obstet Gynecol 2:366–374.PubMedCrossRefGoogle Scholar
  211. Miller CL (1995) Nitric oxide therapy for persistent pulmonary hypertension of the newborn. Neonatal Network 14:9–15.PubMedGoogle Scholar
  212. Milligan DWA, Issler H, Massam M, Reynolds EOR (1984) Treatment of neonatal pulmonary interstitial emphysema by lung puncture. Lancet I:1010–1011.CrossRefGoogle Scholar
  213. Milner AD, Hoskyns EW, Hopkin IE (1992) The effects of midtrimester amniocentesis on lung function in the neonatal period. Eur J Pediatr 151:458–460.PubMedCrossRefGoogle Scholar
  214. Milner AD. Saunders RA, Hopkin IE (1978) Effects of delivery by Caesarian section on lung mechanics and lung volume on human neonates. Arch Dis Child 53:545–548.PubMedCrossRefGoogle Scholar
  215. Milunsky A, Graef JW, Gaynor MF (1968) Methotrex-ate-induced congenital malformations with a review of the literature. J Pediatr 72:790–795.PubMedCrossRefGoogle Scholar
  216. Mitchell AA (2003) Systematic identification of drugs that cause birth defects: a new opportunity. N Engl J Med 349:2556–2559.PubMedCrossRefGoogle Scholar
  217. Moessinger AC, Driscoll JM, Wigger HJ (1978) High incidence of lung perforation by chest tube in neonatal pneumothorax. J Pediatr 92:635–637.PubMedCrossRefGoogle Scholar
  218. Mohrenschlager M, Weigl LB, Haug S, et al. (2003) Iat-rogenic burns by warming bottles in the neonatal period: report of two cases and review of the literature. J Burns Case Rehab 24:52–55.CrossRefGoogle Scholar
  219. Mokrohisky ST, Levine RL, Blumhagen JD, Wesenberg RL, Simmons MA (1978) Low positioning of umbilical artery catheter increases associated complications in newborn infants. N Engl J Med 299:561–564.PubMedCrossRefGoogle Scholar
  220. Monson RR, Rosenberg L, Hartz SC, Shapiro S, Heinonen OP, Slone D (1973) Diphenylhydantoin and selected congenital malformations. N Engl J Med 289:1049–1052.PubMedGoogle Scholar
  221. MRC (1978) An assessment of the hazards of amniocen-tesis. Br J Obstet Gynaecol 85(suppl 2):1–41.Google Scholar
  222. Najak ZD, Harris EM, Lazzara A, Pruitt AW (1983) Pulmonary effects of furosemide in preterm infants with lung disease. J Pediatr 102:758–763.PubMedCrossRefGoogle Scholar
  223. Nash G, Blennerhassett J-B, Pontoppidan H (1967) Pulmonary lesions associated with oxygen therapy and artificial ventilation. N Engl J Med 276:368– 374.PubMedCrossRefGoogle Scholar
  224. Neilson I, Gosden C (1991) First trimester prenatal diagnosis: chorionic villus sampling or amniocente-sis? Br J Obstet Gynaecol 98:849–852.PubMedGoogle Scholar
  225. Newton ER, Schroeder BC, Knape KG, Bennett BL (1995) Epidural analgesia and uterine function. Obstet Gynecol 85:749–755.PubMedCrossRefGoogle Scholar
  226. Ng PC, Thomson MA, Dear PRF (1990) Dexamethasone and infection in preterm babies: a controlled study. Arch Dis Child 65:54–58.PubMedCrossRefGoogle Scholar
  227. Ng PC, Brownlee KG, Dear PRF (1991) Gastroduodenal perforation in preterm babies treated with dexa-methasone for bronchopulmonary dysplasia. Arch Dis Child 66:1164–1166.PubMedCrossRefGoogle Scholar
  228. National Institute of Child Health and Development (NICHD) (1976) National Registry for Amniocentesis Study Group 1976. Midtrimester amniocentesis for prenatal diagnosis—safety and accuracy. JAMA 236:1471–1476.CrossRefGoogle Scholar
  229. Nicolaides K (1988) Cordocentesis. Clin Obstet Gynecol 31:123–135.PubMedCrossRefGoogle Scholar
  230. Nicolini U, Nicolaidis P, Fisk NM, Tannirandorn Y, Rodeck CH (1990) Fetal blood sampling from the intrahepatic vein: an analysis of safety and clinical experience with 214 procedures. Obstet Gynecol 76:47–53.PubMedGoogle Scholar
  231. Nicolini U, Rodeck CH (1992) Fetal blood and tissue sampling. In: Brock D, Rodeck CH, Ferguson-Smith M (eds) Prenatal Diagnosis and Screening Churchill Livingstone, Edinburgh p. 47.Google Scholar
  232. Nikkila A, Valentin L, Thelin A, Jorgensen C (2002) Early amniocentesis and congenital foot deformities. Fetal Diagn Ther 17:129–132.PubMedCrossRefGoogle Scholar
  233. Northway WH, Rosan RC, Porter DY (1967) Pulmonary disease following respiratory therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med 276:3357–368.CrossRefGoogle Scholar
  234. Norton ME, Merrill J, Cooper BA, Kuller JA, Clyman RI (1993) Neonatal complications after the administration of indomethacin for preterm labour. N Engl J Med 329:1602–1607.PubMedCrossRefGoogle Scholar
  235. O'Brien PC, Noller KL, Robboy SJ, et al. (1979). Vaginal epithelial changes in young women enrolled in the National Cooperation Diethylstilbestrol Adenosis (DESAD) project. Obstet Gynecol 53:300–308.PubMedGoogle Scholar
  236. Oeda K, Saito A, Nakano H, et al. (1980) Cortical hyper-ostosis following long term administration of pros-taglandin E in infants with cyanotic congenital heart disease. J Pediatr 97:834.CrossRefGoogle Scholar
  237. Oh W, Stern L (1977) Diseases of the respiratory system. In: Behrman RE (ed) Neonatal and perinatal medicine: diseases of the fetus and infant. St Loui, CV Mosby p. 558.Google Scholar
  238. O'Mahony F, Settatree R, Platt C, Johanson R (2005). Review of singleton fetal and neonatal deaths associated with cranial trauma and cephalic delivery during a national intrapartum-related confidential enquiry. Br J Obstet Gynaecol 112:619–626.Google Scholar
  239. Omu AE, Al Quattan F, Al Ashkanane L (1995) Shoulder dystocia: a continuing obstetric challenge. J Obstet Gynaecol 15:373–378.CrossRefGoogle Scholar
  240. O'Neill EA, Chwals WH, O'Shea MD, Turner CS (1992) Dexamethasone treatment during ventilator dependency: possible life threatening gastrointestinal complications. Arch Dis Child 67:10–11.CrossRefGoogle Scholar
  241. O'Neill JA (1984) Experience with iatrogenic laryngeal and tracheal stenoses. J Pediatr Surg 19:235–238.PubMedCrossRefGoogle Scholar
  242. Oppenheimer SJ, Snodgrass GJAI (1980) Neonatal rickets. Histopathology and quantitative bone changes. Arch Dis Child 55:945–949.PubMedCrossRefGoogle Scholar
  243. Orlandi F, Damiani G, Jakil C, Lauricella S, Bertolino O, Maggio A (1990) The risks of early cordocentesis (12–21 weeks): analysis of 500 procedures. Prenat Diagn 10:425–428.PubMedCrossRefGoogle Scholar
  244. OSIRIS Collaborative Group (1992) Early versus delayed neonatal administration of a synthetic surfactant— the judgment of OSIRIS. The OSIRIS Collaborative Group (open study of infants at high risk of or with respiratory insufficiency—the role of surfactant. Lancet 340:1363–1369.CrossRefGoogle Scholar
  245. Pape KE, Armstrong DL, Fitzhardinge PM (1976) Central nervous system pathology associated with mask ventilation in the very low birth weight infant: a new aetiology for intracerebellar haemorrhages. Paediatrics 58:473–483.Google Scholar
  246. Parilla BV, Dooley SL, Jansen SD, Socol ML (1993) Iatrogenic respiratory distress syndrome following elective repeat caesarian delivery. Obstet Gynecol 81:392–395.PubMedGoogle Scholar
  247. Patel J, Roberts I, Azzopardi D, Hamilton P, Edwards AD (2000) Randomized double-blind controlled trial comparing the effects of Ibuprofen with Indo-methacin on cerebral haemodynamics in preterm infants with patent ductus arteriosus. Pediatr Res 47:36–45.PubMedCrossRefGoogle Scholar
  248. Pastore LM, Hertz-Picciotto I, Beaumont JJ (2000) Risk of stillbirth from medications, illnesses and medical procedures. Paediatr Perinat Epidemiol 14:381–382.Google Scholar
  249. Pauli RM, Hall JG (1979) Warfarin embryopathy. Lancet ii:144.CrossRefGoogle Scholar
  250. Peden VH, Witzleben CL, Skelton MA (1971) Total par-enteral nutrition. J Pediatr 78:180–181.PubMedGoogle Scholar
  251. Pereira GR, Fox WW, Stanley CA, Baker L, Schwartz JG (1980) Decreased oxygenation and hyperlipemia during intravenous fat infusions in premature infants. Pediatrics 66:26–30.Google Scholar
  252. Perlow JH, Wigton T, Hart J, Strassner HT, Nageotte MP, Wolli BM (1996) Birth trauma. A five-year review of incidence and associated perinatal factors. J Reprod Med 41:754–760.PubMedGoogle Scholar
  253. Petrikovsky BM, Schneider E, Smith-Levitin M, Gross B (1998) Cephalhaematoma and caput succedaneum: do they always occur in labor. Am J Obstet Gynecol 179:906–908.PubMedCrossRefGoogle Scholar
  254. Phelps DL, Lachman RS, Leake RD, Oh W (1972) The radiologic localization of the major aortic tributaries in the newborn infant. J Pediatr 81:336–339.PubMedCrossRefGoogle Scholar
  255. Powell H, Swarner O, Gluck L, Lampert P (1973) Hex-chlorophene myelinopathy in premature infants. J Pediatr 82:976–981.PubMedCrossRefGoogle Scholar
  256. Pratt PC, Vollmer RT, Shelburne JD, Crapo JD (1979) Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. Am J Pathol 95:191–208.PubMedGoogle Scholar
  257. Pratti D, Capelli C, Rebulla P, et al. (1998) The current risk of retroviral infections transmitted by transfusion in patients who have undergone multiple transfusions. Cooleycare Co-operative Group. Arch Int Med 158:1566–1569.CrossRefGoogle Scholar
  258. Pryds O, Griesen G, Johansen KH (1988) Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus. Eur J Pediatr 147:315–316.PubMedCrossRefGoogle Scholar
  259. Quak JME, Szatmari A, van den Anker JN (1993) Cardiac tamponade in a preterm neonate secondary to a chest tube. Acta Paediatr 82:490–491.PubMedCrossRefGoogle Scholar
  260. Quintero RA, Morales WJ, Allen M, Bornick PW, Arroyo J, Le Para G (1999) Treatment of iatrogenic previable premature rupture of membranes with intra-amniotic injection of platelets and cryoprecipitate (amniopatch): preliminary experience. Am J Obstet Gynecol 181:744–749.PubMedCrossRefGoogle Scholar
  261. Raju TNK, Langenberg P (1993) Pulmonary haemorrhage and exogenous surfactant replacement therapy: a meta-analysis. J Pediatr 123:603–610.PubMedCrossRefGoogle Scholar
  262. Raman-Wilms L, Tseng AL, Wighardt S, Einarson TR, Koren G (1995) Fetal genital effects of first trimester sex hormone exposure: a meta-analysis. Obstet Gynecol 85:141–149.PubMedCrossRefGoogle Scholar
  263. Rehder H (1978) Fetal limb deformities due to amniotic constrictions (a possible consequence of preceding amniocentesis). Pathol Res Pract 162:316–326.PubMedGoogle Scholar
  264. Rennie JM, Baker B, Lucas A (1989) Does dexametha-sone suppress the ACTH response in preterm babies? Arch Dis Child 64:612–613.PubMedCrossRefGoogle Scholar
  265. Rey C, Marache P, Watel A, Francart C (1987) Iatro-genic false aneurysm of the brachial artery in an infant. Eur J Pediatr 146:438–439.PubMedCrossRefGoogle Scholar
  266. Reynolds EO, Taghizadeh A (1974) Improved prognosis of infants mechanically ventilated for hyaline membrane disease. Arch Dis Child 49:505–515.PubMedCrossRefGoogle Scholar
  267. Rhoads GG, Jackson LG, Schlesselman SE, et al. (1989) The safety and efficacy of chorionic villus sampling for early prenatal diagnosis of cytogenetic abnormalities. N Engl J Med 320:609–617.PubMedGoogle Scholar
  268. Rizvi ZB, Aniol HS, Myers TF, Zeller WP, Fisher SG, Anderson CL (1992) Effects of dexamethasone on the hypothalamic-pituitary-adrenal axis in preterm infants. J Pediatr 120:961–965.PubMedCrossRefGoogle Scholar
  269. Roberton NRC (1976) Treatment of cystic ventilator lung disease. Proc Roy Soc Med 69:344–345.PubMedGoogle Scholar
  270. Robinson CM, Cox MA (1986) The incidence of renal calcification in low birth weight (LBW) infants on lasix for bronchopulmonary dysplasia (BPD). Pediatr Res 20:359A.Google Scholar
  271. Rodeck CH, Fisk NM, Fraser DI, Nicolini U (1988) Long-term in-utero drainage of fetal hydrothorax. New Engl J Med 319:1135–1138.PubMedCrossRefGoogle Scholar
  272. Rosa FW (1983). Teratogenicitiy of isoretinoin. Lancet II:513.CrossRefGoogle Scholar
  273. Rubin PC, Craig GF, Gavin K, Sumner D (1986). Prospective survey of use of therapeutic drugs, alcohol and cigarettes during pregnancy. Br Med J 292:81–83.CrossRefGoogle Scholar
  274. Rubin PC (1995) Prescribing in pregnancy 2ed. BMJ Publishing London.Google Scholar
  275. Rubin PC (1998) Drug treatment during pregnancy. Br Med J 317:1503–1506.Google Scholar
  276. Rush RW, Keirse MJNC, Howat P, Baum JD, Anderson AB, Turnbull AC (1976) Contribution of preterm delivery to perinatal mortality. Br Med J II:965–968.CrossRefGoogle Scholar
  277. Rushton DI (1981) Examination of products of conception from previable human pregnancies. J Clin Pathol 34:819–835.PubMedCrossRefGoogle Scholar
  278. Rybak LP (1982) Pathophysiology of frusemide ototox-icity. J Otolaryngol 11:127–135.PubMedGoogle Scholar
  279. Salamy A, Eldrege L, Tooley WH (1989) Neonatal status and hearing loss in high-risk infants. J Pediatr 114:847–852.PubMedCrossRefGoogle Scholar
  280. Sapin E, Gumpert L, Bonnard A, et al. (2000) Iatrogenic pharyngooesophageal perforation in premature infants. Eur J Pediatr Surg 10:83–87.PubMedCrossRefGoogle Scholar
  281. Sargent JW, Seffi RJ (1970) Properties of perfluoronated liquids. Fed Proceed 29:1699–1703.Google Scholar
  282. Saunders RA, Milner AD (1978) Pulmonary pressure/ volume relationships during the last phase of delivery and the first postnatal breaths in human subjects. J Pediatr 93:667–673.PubMedCrossRefGoogle Scholar
  283. Schaap AH, van der Pol HG, Boer K, Leschot NJ, Wolf H (2002) Long term follow-up of infants after trans-cervical chorionic villus sampling and after amnio-centesis to compare congenital abnormalities and health status. Prenat Diagn 22:598–604.PubMedCrossRefGoogle Scholar
  284. Schumacher RE, Barks JD, Johnston MV, et al. (1988) Right-sided brain lesions in infants following extracorporeal membrane oxygenation. Pediatrics 82:155–161.PubMedGoogle Scholar
  285. Seeds JW (2004) Diagnostic midtrimester amniocente-sis: how safe? Am J Obstet Gynecol 191:607–615.PubMedCrossRefGoogle Scholar
  286. Segal S, Chu J (1963) Neonatal respiratory adaptation. US Department of Health, Education and Welfare. Bethesda, National Institutes of Health pp. 184– 188.Google Scholar
  287. Shuman RM, Leech RW, Alvord EC (1974) Neurotoxic-ity of hexachlorophene in the human: 1. A clinico-pathologic study of 248 children. Pediatrics 54:689–695.PubMedGoogle Scholar
  288. Simmons MA, Levine RV, Lubchenco LO, Guggenheim MA (1978) Warning: serious sequelae of temporal arterial catheterization. J Pediatr 92:284.PubMedCrossRefGoogle Scholar
  289. Simonsen K, Graem N, Rothman LP, Degu H (1995) Iatrogenic radiant heat burns in severely asphyxiated newborns. Acta Paediatr 84:1438–1440.PubMedCrossRefGoogle Scholar
  290. Simpson NE, Dallaire L, Miller JR et al. (1976) Prenatal diagnosis of genetic disease in Canada: report of a collaborative study. Can Med Assoc J 115:739–746.PubMedGoogle Scholar
  291. Sivieri EM. Moskoqitz GD, Shaffer TF (1981) Instrumentation for measurement of cardiac output by the direct Fick method during liquid breathing. Biomed Res 8:75–83.Google Scholar
  292. Sjöberg I, Erichs K, Bjerre I (1988) Cause and effect of obstetric (neonatal) brachial plexus palsy. Acta Pae-diatr Scand 77:357–364.CrossRefGoogle Scholar
  293. Smidt-Jensen S, Permin M, Philip J (1991) Sampling success and risk by transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis: a randomised study. Ultrasound Obstet Gynecol 1:86–90.PubMedCrossRefGoogle Scholar
  294. Sosenko IRS, Rodriquez-Pierce M, Bancalari E (1993) Effect of early initiation of intravenous lipid administration on the incidence and severity of chronic lung disease in premature infants. J Pediatr 123:975–982.PubMedCrossRefGoogle Scholar
  295. Soutar D, Harding J, McCowan L, O'Donnell C, McLeay E, Baxendale H (1998) Antenatal indomethacin— adverse fetal effects confirmed. Aus NZ J Obstet Gynacol 38:11–16CrossRefGoogle Scholar
  296. Speidel BD, Meadow SR (1972) Maternal epilepsy and abnormalities of the fetus and newborn. Lancet ii:839–843.CrossRefGoogle Scholar
  297. Squier M, Chamberlain P, Zaiwalla Z, et al. (2000) Five cases of brain injury following amniocentesis in mid-term pregnancy. Dev Med Child Neurol 42:554–560.PubMedCrossRefGoogle Scholar
  298. Steele RW, Metz JR, Bass JW, Du Bois JJ (1971) Pneu-mothorax and pneumomediastinum in the newborn. Radioloy 98:629–632.Google Scholar
  299. Stevenson D, Walther F, Long W, et al. (1992) Controlled trial of a single dose of synthetic surfactant at birth in premature infants weighing 500–699 grams. J Pediatr 120(suppl):3–12.Google Scholar
  300. Strauss A, Hasbargen U, Paek B, Bauerfeind I, Hepp H (2000) Intra-uterine fetal demise caused by amniotic band syndrome after standard amniocentesis. Fetal Diagn Ther 15:4–7.PubMedCrossRefGoogle Scholar
  301. Strickler SM, Danksy LV, Miller M, Seui M-H, Andermann E, Spielberg SP (1985) Genetic predisposition to phenytoin-induced birth defects. Lancet ii:746–749.CrossRefGoogle Scholar
  302. Sydorak RM, Albanese CT (2003) Minimal access techniques for fetal surgery. World J Surg 27:95–102.PubMedCrossRefGoogle Scholar
  303. Tabor A, Philip PJ, Madsen M (1986) Randomised controlled trial of genetic amniocentesis in 4606 low risk women. Lancet i:1287–1293.CrossRefGoogle Scholar
  304. Taghizadeh A, Reynolds EOR (1976) Pathogenesis of bronchopulmonary dysplasia following hyaline membrane dysplasia. Am J Pathol 82:241–264.PubMedGoogle Scholar
  305. Tamir S, de Rojas-Walker T, Wishnok JS, Tannenbaum SR (1996) DNA damage and genotoxicity by nitric oxide. Methods Enzymol 206:230–243.CrossRefGoogle Scholar
  306. Tarnow-Mordi WO, Wilkinson AR (1985) Inspiratory: expiratory ratio and pulmonary interstitial emphysema. Arch Dis Child 59:1046–1051.Google Scholar
  307. Therkensen AJ, Rehder H (1981) Intestinal atresia caused by second trimester amniocentesis. Br J Obstet Gynaecol 88:559–562.Google Scholar
  308. Thiersch JB (1952) Therapeutic abortions with folic acid antagonist, 4-aminopterogluitamic acid (4-amino PGA) administered by the oral route. Am J Obstet Gynecol 63:1298–1304.PubMedGoogle Scholar
  309. Thompson PJ, Greenough A, Nicolaides KH (1992) Lung volume measured by functional residual capacity in infants following first trimester amniocentesis or chorionic villus sampling. Br J Obstet Gynaecol 99:479–482.PubMedGoogle Scholar
  310. Thorp JA, Hu DH, Albin RM, et al. (1993) The effect of intrapartum epidural analgesia on multiparous labour: a randomised, controlled, prospective trial. Am J Obstet Gynecol 169:851–858.PubMedGoogle Scholar
  311. Tiboni GM, Iammarrone E, Piccirill G, Liberati M, Bellati U (1998) Aspirin pretreatment potentiates hyperthermia-induced teratogenesis in the mouse. Am J Obstet Gynecol 178:270–279.PubMedCrossRefGoogle Scholar
  312. Tooley WH (1979) Epidemiology of bronchopulmonary dysplasia. J Pediatr 95:851–855.PubMedCrossRefGoogle Scholar
  313. Towers CV, Carr MH, Padilla G, Asrat T (1998) Potential consequences of widespread antepartum use of ampicillin. Am J Obstet Gynecol 179:879–883.PubMedCrossRefGoogle Scholar
  314. UK Collaborative ECMO Trial Group (1996) UK collaborative randomised trial of neonatal extracorpo-real membrane oxygenation. Lancet 348:75–82.CrossRefGoogle Scholar
  315. Vailus GN, Brouillette RT, Scott JP, Shkolnik A, Conway J, Wiringa K (1986) Neonatal aortic thrombosis: recent experience. J Pediatr 109:101–108.CrossRefGoogle Scholar
  316. van der Vliet A, O'Neill CA, Halliwell B, Cross CE, Kaur H (1994) Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evi-dence for hydroxyl radical production from per-oxynitrite. FEBS Lett 339:89–92.PubMedCrossRefGoogle Scholar
  317. van Houten J, Long W, Mullet M (1992) Pulmonary haemorrhage in premature infants after treatment with synthetic surfactant: an autopsy evaluation. J Pediatr 120(suppl):40–44.Google Scholar
  318. van Lierde S, Cornelis A, Devlieger H, Moerman P, Lauweryns J, Eggermont E (1991) Different patterns of pulmonary sequelae after hyaline membrane disease: heterogenicity of bronchopulmonary dys-plasia. Biology of the Neonate 60:152–162.PubMedGoogle Scholar
  319. van Meurs KP, Wright LL, Ehrenkranz RA, et al. (2005). Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 353:13–22.PubMedCrossRefGoogle Scholar
  320. Venkataraman PS, Tsang RC, Chen IW, Sperling MA (1987) Pathogenesis of early neonatal hypocalcae-mia: studies of serum calcitonin, gastrin, plasma glu-cagon. J Pediatr 110:599–603.PubMedCrossRefGoogle Scholar
  321. Vyas H, Field D, Milner AD (1986) Determinants of the first inspiratory volume and functional residual capacity at birth. Pediatr Pulmonol 2:189–193.PubMedCrossRefGoogle Scholar
  322. Wade RV, Young SR (1989) Analysis of fetal loss after transcervical chorionic villus sampling: a review of 719 patients. Am J Obstet Gynecol 161:513–519.PubMedGoogle Scholar
  323. Walters DV, Olver RE (1978) The role of catecholamines in lung liquid absorption at birth. Pediatr Res 12:239–242.PubMedCrossRefGoogle Scholar
  324. Ward RM (1984) Pharmacology of tolazoline. Clin Peri-natol 11:703–713.Google Scholar
  325. Weber TR, Kountzman B (1996) The effects of venous occlusion in cerebral blood flow characteristics during ECMO. J Ped Surg 31:1124–1127.CrossRefGoogle Scholar
  326. Wellesley D, Moore I, Heard M, Keeton B (1998) Two cases of warfarin embryopathy: a re-emergence of this condition. Br J Obstet Gynaecol 105:805–806.PubMedGoogle Scholar
  327. Werler MM, Mitchell AA, Hernandez-Diaz S, Honein MA, The National Birth Defects Prevention Study (2005) Use of over-the-counter medications during pregnancy. Am J Obstet Gynecol 1993:771–777.CrossRefGoogle Scholar
  328. Werner JC, Sicard RE, Hansen TWR, Solomon E, Cowett RM, Oh W (1992) Hypertrophic cardiomyopathy associated with dexamethasone therapy for broncho-pulmonary dysplasia. J Pediatr 120:286–291.PubMedCrossRefGoogle Scholar
  329. Wesstrom G, Finnstrom O, Stenport G (1979) Umbilical artery catheterisation in newborns. I. Thrombosis in relation to catheter type and position. Acta Paediatr Scand 68:575–581.PubMedCrossRefGoogle Scholar
  330. World Health Organiztion Consultation on First Trimester Fetal Diagnosis (1986) Risk evaluation in chorion villus sampling. Prenat Diagn 6:451–456.CrossRefGoogle Scholar
  331. Wigglesworth JS (1991) Pathology of intrapartum and early neonatal death in the normally formed infant. In: Wigglesworth JS, Singer DS (eds) Textbook of Fetal and Perinatal Pathology. Blackwell Scientific Publications. Oxford pp. 285–306.Google Scholar
  332. Wigglesworth JS, Husemeyer RP (1977) Intracranial birth trauma in vaginal breech delivery: the continued importance of injury to the occipital bone. Br J Obstet Gynaecol 84:684–691.PubMedGoogle Scholar
  333. Wilkinson A, Baum JD, Keeling JW (1981) Gluteal skin necrosis after umbilical arterial catheterization. Arch Dis Child 56:237–238.PubMedCrossRefGoogle Scholar
  334. Wilkinson C, McIlwaine G, Boulton-Jones C, Cole S (1998) Is a rising caesarean section rate inevitable. Br J Obstet Gynaecol 105:45–52.PubMedGoogle Scholar
  335. Williams AF, Jones M (1992) Dexamethasone increases plasma amino acid concentrations in bronchopul-monary dysplasia. Arch Dis Child 67:5–9.PubMedCrossRefGoogle Scholar
  336. Yates PO (1959) Birth trauma to the vertebral arteries. Arch Dis Child 34:436–441.PubMedCrossRefGoogle Scholar
  337. Yamamoto M, El Nurr L, Robyr R, Leleu F, Takahashi Y, Ville Y (2005) Incidence and impact of perio-perative complications in 175 fetoscopy-guided laser coagulations of chorionic plate anastomoses in fetofetal transfusion syndrome before 26 weeks gestation. Am J Obstet Gynecol 193:1110– 1116.PubMedCrossRefGoogle Scholar
  338. Yoon BH, Romero R, Park JS, et al. (2000) Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 182:675–681.PubMedCrossRefGoogle Scholar
  339. Young BK, Roque H, Abdelhak YE, Poiolek D, Demopulos R, Lockwood CJ (2000) Minimally invasive endoscopy in the treatment of preterm premature rupture of membranes by application of fibrin sealant. J Perinat Med 28:326–2330.PubMedCrossRefGoogle Scholar
  340. Yu VYH (1992) Parenteral nutrition in the newborn. In: Robertson NRC (ed) Textbook of neonatology, 2nd ed. Edinburgh, Churchill Livingstone pp. 289–301.Google Scholar
  341. Zelson C, Lee SJ, Pearl M (1974) The incidence of skull fractures underlying cephalhaematomas in newborn infants. J Pediatr 85:371–373.PubMedCrossRefGoogle Scholar
  342. Zerella JT, Trump DS (1987) Surgical management of neonatal interstitial emphysema. J Pediatr Surg 22:34–37.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2007

Authors and Affiliations

  • Allan G. Howatson
    • 1
  1. 1.Department of Paediatric PathologyRoyal Hospital for Sick ChildrenGlasgowUK

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