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Animal Models in Genitourinary Malignancies

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Book cover Urological Oncology

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Abstract

In vitro cell culture techniques facilitate cultivation of human- and animal-origin cells for prolonged periods of time. Cell lines, harvested from primary or metastatic sites, maintain some of the phenotypical characteristics of the tumor of origin. However, establishing cell lines from early or premalignant disease, such as primary cultures, is more difficult. Cells can be immortalized inadvertently by exposure to environmental carcinogens or by repeated passage, transfection with viral or human oncogenes, and chemical or radiation exposure. Cell lines are vulnerable to significant interspecies and intercell-type contamination.

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Author information

Authors and Affiliations

  1. Institute of Human Genetics, University of Newcastle-Upon-Tyne Central Parkway, Newcastle-Upon-Tyne, UK

    Prabhakar Rajan MA, MBBChir, MRCS

  2. Department of Surgical Oncology, Beatson Institute for Cancer Research, Glasgow, UK

    Hing Y. Leung PhD, FRCS(Urol)

Authors
  1. Prabhakar Rajan MA, MBBChir, MRCS
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  2. Hing Y. Leung PhD, FRCS(Urol)
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Editor information

Editors and Affiliations

  1. St. Bartholomew’s and Homerton Hospitals Queen Mary Barts and the London School of Medicine and Dentistry, University of London, London, UK

    Vinod H. Nargund PhD, FRCS (Urol), FEBU (Chair, Uro-Oncology MDT and Consultant Urological Surgeon) (Chair, Uro-Oncology MDT and Consultant Urological Surgeon)

  2. Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA

    Derek Raghavan MD, PhD, FACP, FRACP (Chairman and Director) (Chairman and Director)

  3. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA

    Howard M. Sandler MD (Professor and Senior Associate Chair) (Professor and Senior Associate Chair)

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© 2008 Springer-Verlag London Limited

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Rajan, P., Leung, H.Y. (2008). Animal Models in Genitourinary Malignancies. In: Nargund, V.H., Raghavan, D., Sandler, H.M. (eds) Urological Oncology. Springer, London. https://doi.org/10.1007/978-1-84628-738-1_2

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  • DOI: https://doi.org/10.1007/978-1-84628-738-1_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-387-1

  • Online ISBN: 978-1-84628-738-1

  • eBook Packages: MedicineMedicine (R0)

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