Skip to main content
SpringerLink
Log in

Renal Cell Carcinoma: Overview

  • Chapter
Urological Oncology

Abstract

Renal cell carcinoma (RCC) accounts for 3% of all adult cancers. The incidence rates for kidney cancer are highest in European and Scandinavian countries and North America (1). It is estimated that 36,160 new cases of kidney and renal pelvis cancer were diagnosed in 2005, with an estimated 12,660 resulting deaths in the United States (2). There has been a 30% increase in incidence in the last 20 years. Although this increased incidence is partly a result of more widespread and aggressive imaging, current reports show a real increase in incidence. Renal cell carcinoma is a tumor of adults occurring primarily after the 5th decade of life. It occurs one-and-a-half times as often in men as in women (3:2) (3). Childhood RCC is uncommon, representing only 2% to 6% of all renal tumors in children. Bilateral tumors are identified in 2% to 5% of the patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Parkin DM, Muir CS, Whelan S, et al. Cancer Incidence in Five Continents, vol VI. IARC Scientific Publication No. 120. Lyon, France: World Health Organization, International Agency for Research on Cancer, 1992.

    Google Scholar 

  2. Jemal A, Murray T, Ward E, et al. Cancer statistics 2005. CA Cancer J Clin 2005; 55:10–30.

    Article  PubMed  Google Scholar 

  3. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics 1999. CA Cancer J Clin 1999;49:8–31.

    Article  CAS  PubMed  Google Scholar 

  4. Choyke PL, Glenn GM, Walther MM, et al. State of the art: hereditary renal cancers. Radiology 2002;226:33–46.

    Article  Google Scholar 

  5. Bergstrom A, Hsieh CC, Lindblad P, et al. Obesity and renal cell cancer—a quantitative review. Br J Cancer 2001;85:984–990.

    Article  CAS  PubMed  Google Scholar 

  6. Srikanth MS, Fox SR, Oh KH, et al. Renal cell carcinoma following bariatric surgery. Obes Surg 2005;15(8):1165–1170.

    Article  PubMed  Google Scholar 

  7. Lindblad P, Chow WH, Chan J, et al. The role of diabetes mellitus in the etiology of renal cell cancer. Diabetologia 1999;42(1):107–121.

    Article  CAS  PubMed  Google Scholar 

  8. Kirkali Z, Obek C. Clinical aspects of renal cell carcinoma. EAU Update Ser 2003;1: 189–198.

    Article  Google Scholar 

  9. Lindner V, Lang H, Jacqmin D. Pathology and genetics in renal cell cancer. Eur Urol 2003; suppl 1:197–208.

    Google Scholar 

  10. Lee CT, Katz J, Shi W, et al. Surgical management of renal tumors 4 cm or less in a contemporary cohort. J Urol 2000;163:730–736.

    Article  CAS  PubMed  Google Scholar 

  11. Bosniak MA, Birnbaum BA, Krinsky GA, et al. Small renal parenchymal neoplasms: further observations on growth. Radiology 1995;197:589–597.

    CAS  PubMed  Google Scholar 

  12. Wu SL, Kothari P, Wheeler TM, Reese T, et al. Cytokeartins 7 and 20 immunoreactivity in chromophobe renal cell carcinomas and renal oncocytomas. Mod Pathol 2002; 15:712–717.

    Article  PubMed  Google Scholar 

  13. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655–663.

    Article  CAS  PubMed  Google Scholar 

  14. Linehan WM, Lerman MI, Zbar B. Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer. JAMA 1995;273:564–570.

    Article  CAS  PubMed  Google Scholar 

  15. Linehan WM, Grubb RL, Coleman JA, et al. The genetic basis of kidney cancer: implications for gene specific clinical management. BJU Int 2005;95(suppl 2):2–7.

    Article  CAS  PubMed  Google Scholar 

  16. Pavlovich CP, Grubb RL 3rd, Hurley K, et al. Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome. J Urol 2005;173:1482–1486.

    Article  PubMed  Google Scholar 

  17. Isreal GM, Bosniak MA. Renal imaging for diagnosis and staging of renal cell carcinoma. Urol Clin North Am 2003;30:499–514.

    Article  Google Scholar 

  18. Shvarts O, Lam JS, Kim L, Belldegrun AS. Staging of renal cell carcinoma: current concepts. BJU Int 2005;95(suppl 2):8–13.

    Article  PubMed  Google Scholar 

  19. Kattan MW, Reuter V, Motzer RJ, Katz J, Russo P. A postoperative prognostic nomogram for renal cell carcinoma. J Urol 2001;166:63–67.

    Article  CAS  PubMed  Google Scholar 

  20. Lang H, Jacqmin D. Prognostic factors in renal cell carcinoma. Eur Urol Update Ser 2003;1(4):215–219.

    Article  Google Scholar 

  21. Pantuck AJ, Zisman A, Rauch MK, Belldegrun AS. Incidental renal tumors. Urology 2000;56:190–196.

    Article  CAS  PubMed  Google Scholar 

  22. Campbell S, Novick A. Expanding the indications for elective nephrectomy: Is this advisable? Eur Urol 2006;49:952–954.

    Article  PubMed  Google Scholar 

  23. Becker F, Siemer S, Hack M, et al. Excellent long-term cancer control with elective nephron saving surgery for selected renal cell carcinomas measuring more than 4cm. Eur Urol 2006;49:1058–1064.

    Article  PubMed  Google Scholar 

  24. Uzo RG, Novick AC. Nephron-saving surgery for renal tumors: indications, techniques and outcomes. J Urol 2001;166:6–18.

    Article  Google Scholar 

  25. Wickham JE. Conservative renal surgery for adenocarcinoma. The place of bench surgery. Br J Urol 1975;47:25–36.

    Article  CAS  PubMed  Google Scholar 

  26. Weld JK, Landman J. Comparison of cryoablation, radiofrequency ablation, land HIFU for treating small renal tumors. BJU Int 2005;96:1224–1229.

    Article  PubMed  Google Scholar 

  27. Hofmann HS, Neef H, Krohe K, et al. Prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. Eur Urol 2005;48:77–81.

    Article  PubMed  Google Scholar 

  28. Romis L, Cindolo L, Patard JJ, et al. Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database. Eur Urol 2004;45:53–57.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Dokuz Eylül University School of Medicine, Izmir, Turkey

    Ziya Kirkali MD, PhD

  2. Department of Urology, Ege University, Izmir, Turkey

    Cag Cal MD

Authors
  1. Ziya Kirkali MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cag Cal MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St. Bartholomew’s and Homerton Hospitals Queen Mary Barts and the London School of Medicine and Dentistry, University of London, London, UK

    Vinod H. Nargund PhD, FRCS (Urol), FEBU (Chair, Uro-Oncology MDT and Consultant Urological Surgeon) (Chair, Uro-Oncology MDT and Consultant Urological Surgeon)

  2. Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA

    Derek Raghavan MD, PhD, FACP, FRACP (Chairman and Director) (Chairman and Director)

  3. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA

    Howard M. Sandler MD (Professor and Senior Associate Chair) (Professor and Senior Associate Chair)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag London Limited

About this chapter

Cite this chapter

Kirkali, Z., Cal, C. (2008). Renal Cell Carcinoma: Overview. In: Nargund, V.H., Raghavan, D., Sandler, H.M. (eds) Urological Oncology. Springer, London. https://doi.org/10.1007/978-1-84628-738-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-738-1_14

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-387-1

  • Online ISBN: 978-1-84628-738-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation