Advertisement

Animal Models

  • Alison M. Bendele
Chapter
Part of the Topics in Bone Biology book series (TBB, volume 4)

Keywords

Anterior Cruciate Ligament Articular Cartilage Subchondral Bone Medial Collateral Ligament Cartilage Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adams ME, Brandt KD (1991) Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J Rheumatol 18:428–435.PubMedGoogle Scholar
  2. 2.
    Bendele AM (1987) Progressive chronic osteoarthritis in femorotibial joints of partial medial meniscectomized guinea pigs. Vet Pathol 24:444–448.PubMedGoogle Scholar
  3. 3.
    Bendele AM, White SL (1987) Early histopathologic and ultrastructural alterations in femorotibial joints of partial medial meniscectomized guinea pigs. Vet Pathol 24:436–443.PubMedGoogle Scholar
  4. 4.
    Bendele AM, Hulman JF (1988) Spontaneous cartilage degeneration in guinea pigs. Arthritis Rheum 31: 561–565.PubMedCrossRefGoogle Scholar
  5. 5.
    Bendele AM, White SL, Hulman JF (1989) Osteoarthritis in guinea pigs: histopathologic and scanning electron microscopic features. Lab Anim Sci 39:115–121.PubMedGoogle Scholar
  6. 6.
    Bendele AM, White SL, Hulman JF, et al (1991) Osteoarthritis, model No. 379. In: Capen CC, Jones TC, Migaki G, eds. Handbook: Animal Models of Human Disease. Washington, DC: Registry of Comparative Pathology.Google Scholar
  7. 7.
    Bendele AM, Bean JS, Hulman JF (1991) Passive role of articular chondrocytes in the pathogenesis of acute meniscectomy-induced cartilage degeneration. Vet Pathol 28:207–215.PubMedGoogle Scholar
  8. 8.
    Bendele AM, Hulman JF (1991) Effects of body weight restriction on the development and progression of spontaneous OA in guinea pigs. Arthitis Rheum 34:1180–1184.CrossRefGoogle Scholar
  9. 9.
    Bendele AM, Bendele RA, Hulman JF, et al (1996) Beneficial effects of diacetylrhein treatment in guinea pigs with spontaneous osteoarthritis. Rev Pract Suppl 6:35–39.Google Scholar
  10. 10.
    Bendele AM, McComb J, Gould T, et al (1999) Animal models of arthritis: relevance to human disease. Toxicol Pathol 27:134–142.PubMedGoogle Scholar
  11. 11.
    Bendele AM (2001) Animal models of osteoarthritis. J Musculoskel Neuron Interact 1(4):363–376.Google Scholar
  12. 12.
    Bendele AM (2002) Animal models of osteoarthritis in an era of molecular biology. J Musculoskel Neuron Interact 2(6) 501–503.Google Scholar
  13. 13.
    Brandt KD, Braunstein EM, Visco DM, et al (1991) Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair. J Rheumatol 18:436–446.PubMedGoogle Scholar
  14. 14.
    Brandt KD (2002) Animal models of osteoarthritis. Biorheology 39:221–235.PubMedGoogle Scholar
  15. 15.
    Brewster M, Lewis EJ, Wilson KL, et al (1998) Ro 32-3555,an orally active collagenase selective inhibitor,prevents structural damage in the STR/ORT mouse model of osteoarthritis. Arthritis Rheum 41:1639–44.PubMedCrossRefGoogle Scholar
  16. 16.
    Brown T, Shaw D (1984) In viro contact stress distribution on the femoral condyles. J Orthop Res 2: 190–199.PubMedCrossRefGoogle Scholar
  17. 17.
    Carlson CS, Loesner RF, Purser CB, et al (1996) Osteoarthritis in cynomolgus macaques. III: effects of age, gender and subchondral bone thickness on the severity of disease. J Bone Miner Res 11:1209–17.PubMedCrossRefGoogle Scholar
  18. 18.
    Caterson B, Blakenship-Paris T, Chandrasekhar S, et al (1991) Biochemical characterization of guinea pig cartilage proteoglycans with the onset of spontaneous osteoarthritis (abstract). Trans Orthop Res Soc 16:251.Google Scholar
  19. 19.
    Caterson B, Hughes C, Johnstone B, et al (1992) Immunological markers of cartilage proteoglycan metabolism in animal and human osteoarthritis. ln: Kuettner K, Schleyerbach R, Peyron J, et al, eds. Articular Cartilage and Osteoarthritis. Wiesbaden, Germany: Raven Press, pp. P415–427.Google Scholar
  20. 20.
    Chateauvert JM, Grynpas MD, Kessler MJ, et al (1990) Spontaneous osteoarthrtitis in Rhesus macques. Characterization of disease and morphometric studies. J Rheumatol 17:73–83.PubMedGoogle Scholar
  21. 21.
    Clements KM, Price JS, Chambers MG, et al (2003) Gene deletion of either IL-1B, ICE, INOS or SLN-1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum 48:3452–3463.PubMedCrossRefGoogle Scholar
  22. 22.
    Colombo C, Butler M, O’Byrne E, et al (1983) A new model of osteoarthritis in rabbits. I. Development of knee joint pathology following lateral meniscectomy and section of the fibular collateral and sesamoid ligaments. Arthritis Rheum 26:875–886.PubMedCrossRefGoogle Scholar
  23. 23.
    Connor JR, LePage C, Swift BA, et al (2005) Effects of an orally administered cathepsin K inhibitor (SB-553484) on the beagle dog medial meniscectomy model of osteoarthritis. OARSI World Congress, December 8–11.Google Scholar
  24. 24.
    Davis MA, Ettinger WH, Neuhaus JM, et al (1989) The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee. Am J Epidemiol 130:278–285.PubMedGoogle Scholar
  25. 25.
    Dedrick DK, Goldstein SA, Brandt KD, et al (1993) A longitudinal study of subchondral bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rhuem. 36:1460–1467.CrossRefGoogle Scholar
  26. 26.
    Dougados M, Nguyen M, Berdah L, et al (1994) Evaluation of the chondro-modulating effect of diacerhein in hip osteoarthritis. Osteoarthritis Cartilage 2:19 (B9).Google Scholar
  27. 27.
    Fassler R, Schengelsberg PNJ, Dausman J, et al (1994) Mice lacking a1 (IX) collagen develop non-inflammatory degenerative joint disease. Proc Natl Acad Sci USA 91:5070–5074.PubMedCrossRefGoogle Scholar
  28. 28.
    Ghosh P, Armstrong S, Read R, et al (1993) Animal models of early osteoarthritis:their use for the evaluation of potential chondroprotective agents. Agents Actions. 39S: 825–834.Google Scholar
  29. 29.
    Glasson SS, Trubetskoy OV, Harlan PM, et al (1996) Blotchy mice: a model of osteoarthritis associated with a metabolic defect. Osteoarthritis Cartilage 4:209–12.PubMedCrossRefGoogle Scholar
  30. 30.
    Glasson SS, Askew R, Sheppard B, et al (2005) Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434(7033): 644–648.PubMedCrossRefGoogle Scholar
  31. 31.
    Guingamp C, Gegout-Pottie P, Philippe L, et al (1997) Mono-iodoacetate-induced experimental osteoarthritis:a dose-response study of loss of mobility, morphology and biochemistry. Arthritis Rheum 40:1670–1679.PubMedCrossRefGoogle Scholar
  32. 32.
    Hayami T, Pickarski M, Zhuo Y, et al (2006) Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 38:234–243(in press).PubMedCrossRefGoogle Scholar
  33. 33.
    Helminen HJ, Kiraly K, Pelttari A, et al (1993) An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). J Clin Invest 92:582–595.PubMedGoogle Scholar
  34. 34.
    Huebner JL, Otterness IG, Freund EM, et al (1998) Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis. Arthritis Rheum 31:877–890.CrossRefGoogle Scholar
  35. 35.
    Janusz MJ, Bendele AM, Brown KK, et al (2002) Induction of osteoarthritis in the rat by surgical tear of the medial meniscus: inhibition of joint damage by a matrix metalloproteinase inhibitor. Osteoarthritis Cartilage 10:785–791.PubMedCrossRefGoogle Scholar
  36. 36.
    Janusz MJ, Little CB, King LE, et al (2004) Detection of aggrecanase-and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. Ostoarthritis Cartilage 12:720–728.CrossRefGoogle Scholar
  37. 37.
    Kammermann JR, Kincaid SA, Rumph PF, et al (1996) Tumor necrosis factor-a (TNF-a) in canine osteoarthritis: immunolocalization of TNF-a, stromelysin and TNF receptors in canine osteoarthritic cartilage. Osteoarthritis Cartilage 4:23–34.PubMedCrossRefGoogle Scholar
  38. 38.
    Kobayashi K, Amiel M, Harwood FL, et al (2000) The long-term effects of hyaluronan during development of osteoarthritis following partial meniscectomy in a rabbit model. Osteoarthritis Cartilage 8:359–365.PubMedCrossRefGoogle Scholar
  39. 39.
    Lindhorst E, Vail TP, Guilak F, et al (2000) Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis. J Orthop Res 18:269–280.PubMedCrossRefGoogle Scholar
  40. 40.
    Marshall KW, Chan AD (1996) Arthroscopic anterior cruciate ligament transection induces canine osteoarthritis. J Rheumatol 23:338–343.PubMedGoogle Scholar
  41. 41.
    Milner JM, Cawston TE (2005) Matrix metalloproteinase knockout studies and the postential use of matrix metalloproteinase inhibitors in the rheumatic diseases. Current Drug Targets Inflamm Allergy 4: 363–375.CrossRefGoogle Scholar
  42. 42.
    Mitchell P, Magna H, Reeves L, et al (1996) Cloning expression and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 97:761–768.PubMedGoogle Scholar
  43. 43.
    Moore EE, Bendele AM, Thompson DL, et al (2005) Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis and Cartilage 13:623–631.PubMedCrossRefGoogle Scholar
  44. 44.
    Moskowwitz RW, Davis W, Sammarco J, et al (1973) Experimentally-induced degenerative joint lesions following partial medial meniscectomy in the rabbit. Arthritis Rheum 16:397–405.CrossRefGoogle Scholar
  45. 45.
    Nordling C, Karlsson-Parra A, Jansson L, et al (1992) Characterization of a spontaneously occurring arthritis in male DBA/1 mice. Arthritis Rheum 35: 717–722.PubMedCrossRefGoogle Scholar
  46. 46.
    Pelletier JP, Martel-Pelletier J (1991) In vivo protective effects of protphylatic treatment with tiaprofenic acid or intraarticular corticosteroids on osteoarthritic lesions in the experimental dog model. J Rheumatol. Suppl 27:127–130.PubMedGoogle Scholar
  47. 47.
    Pelletier JP, Yaron M, Haraoui B, et al (2000) Efficacy and safety of diacerhein in osteoarthritis of the knee. Arthritis Rheum 43:2339–2348.PubMedCrossRefGoogle Scholar
  48. 48.
    Pond MJ, Nuki G (1973) Experimentally-induced osteoarthritis in the dog. Ann Rheum Dis 32:387–388.PubMedGoogle Scholar
  49. 49.
    Price JS, Chambers MG, Poole AR, et al (2002) Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis. Osteoarthritis Cartilage 10:172–179.PubMedCrossRefGoogle Scholar
  50. 50.
    Reboul P, Pelletier J, Tardiff G, et al (1996) The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not synoviocytes. J Clin Invest 97:2011–2019.PubMedCrossRefGoogle Scholar
  51. 51.
    Salminen H, Perala M, Lorenzo P, et al (2000) Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis. Arthritis Rheum 43:1742–8.PubMedCrossRefGoogle Scholar
  52. 52.
    Saamanen AM, Salminen H, de Crombrugghe B, et al (2000) Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in the type II collagen gene. Osteoarthritis Cartilage 8:248–257.PubMedCrossRefGoogle Scholar
  53. 53.
    Silverstein E, Sokoloff L (1958) Natural history of degenerative joint disease in small laboratory animals. 5. Osteoarthritis in guinea pigs. Arthritis Rheum 1: 82–86.PubMedCrossRefGoogle Scholar
  54. 54.
    Slater RR Jr, Bayliss MT, Lachiewicz, et al (1995) Monoclonal antibodies that detect biochemical markers of arthritis in humans. Arthritis Rheum 38:655–659.PubMedCrossRefGoogle Scholar
  55. 55.
    Smale G, Bendele A, Horton WE (1995) Comparison of age-associated degeneration of articular cartilage in Wistar and Fischer 344 rats. Lab Anim Sci 45:191–194.PubMedGoogle Scholar
  56. 56.
    Smith GN, Myers SL, Brandt KD, et al (1999) Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis. Arthritis Rheum 42:545–54.PubMedCrossRefGoogle Scholar
  57. 57.
    Sokoloff L, Crittenden LB, Yamamoto RS, et al (1962) The genetics of degenerative joint disease in mice. Arthritis Rheum 5:531–546.PubMedCrossRefGoogle Scholar
  58. 58.
    Stoop R, Buma P, van der Kraan PM, et al (2000) Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection. Arthritis Rheum. 43:2121–2131.PubMedCrossRefGoogle Scholar
  59. 59.
    Takahashi K, Kubo T, Goomer RS, et al (1997) Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model. Osteoarthritis Cartilage 5:321–9.PubMedCrossRefGoogle Scholar
  60. 60.
    Trumble TN, Billinghurst RC, Bendele AM, et al (2005) Evaluation of changes in vertical ground reaction forces as indicators of meniscal damage after transection of the cranial cruciate ligament in dogs. Am J Vet Res 66(1):156–63.PubMedCrossRefGoogle Scholar
  61. 61.
    Van den Berg WB (2001) Lessons from animal models of osteoarthritis. Curr Opin Rheumatol 13:452–456.PubMedCrossRefGoogle Scholar
  62. 62.
    Van den Berg WB, van Osch GJVM, van der Kraan PM, et al (1993) Cartilage destruction and osteophtes in instability-induced murine osteoarthritis: role of TGFB in osteophyte formation. Agents Actions 40:215–218.PubMedCrossRefGoogle Scholar
  63. 63.
    Van der Kraan PM. Vitters EL, van de Putte LBA, et al (1989) Development of osteoarthritic lesions in mice by metabolic and mechanical alterations in the knee joints. Am J Pathol 135:1001–1014.PubMedGoogle Scholar
  64. 64.
    Van der Kraan PM, Vitters EL, van Beuningen HM, et al (1992) Proteoglycan synthesis and osteophyte formation in metabolically and mechanically induced murine degenerative joint disease: an in vivo autoradiographic study. Int J Exp Pathol 73: 335–350.PubMedGoogle Scholar
  65. 65.
    Van Osch GJVM, van der Kraan PM, van den Berg WM (1994) Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase. J Orthop Res 12: 168–175.PubMedCrossRefGoogle Scholar
  66. 66.
    Van Osch GJVM, van der Kraan PM, Blankevoort L, et al (1996) Relation of ligament damage with site specific cartilage loss and osteophyte formation in collagenase induced osteoarthritis in mice. J Rheumatol 23: 1227–1232.PubMedGoogle Scholar
  67. 67.
    Visco DM, Hill MA, Widmer WR, et al (1996) Experimental osteoarthritis in dogs: a comparison of the Pond-Nuki and medial arthrotomy methods. Osteoarthritis Cartilage 4:9–22.PubMedCrossRefGoogle Scholar
  68. 68.
    Wagner JT, White R, Zwolak L, et al (1993) Induction of collagenase and stomelysin gene expression by mechanical injury in a vascular smooth muscle derived cell line. J Cell Physiol 157:426–437.PubMedCrossRefGoogle Scholar
  69. 69.
    Walton M (1977) Degenerative joint disease in the mouse knee: histologic observations. J Pathol 123: 109–122.PubMedCrossRefGoogle Scholar
  70. 70.
    Walton M (1979) Patellar displacement and osteoarthrosis of the knee joint of mice. J Pathol 127:165–172.PubMedCrossRefGoogle Scholar
  71. 71.
    Watson PJ, Hall LD, Malcolm A, et al (1996) Degenerative joint disease in the guinea pig: use of magnetic resonance imaging to monitor progression of bone pathology. Arthritis Rheum 39:1327–1337.PubMedCrossRefGoogle Scholar
  72. 72.
    Wilhelmi G, Maier R (1987) Observations on the influence of weight-bearing stress and movements on the joints of mice predisposed to osteoarthritis. Aktuel Rheumatol 12:161–167.CrossRefGoogle Scholar
  73. 73.
    Williams JM, Brandt KD (1985) Triamcinolone hexacetetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum 28:1267–1274.PubMedCrossRefGoogle Scholar
  74. 74.
    Yamamoto H, Iwase N (1998) Spontaneous osteoarthritic lesions in a new mutant strain of the mouse. Exp Anim 47:131–135.PubMedCrossRefGoogle Scholar
  75. 75.
    Yamamoto H, Iwase N, Kohno M (1999) Histopathological characterization of spontaneously developing osteo- arthropathy in the BCBC/Y mouse established newly from B6C3F1 mice. Exp Toxicol Pathol 51:15–20.PubMedGoogle Scholar
  76. 76.
    Yamamoto K, Shishido T, Masaoka T, et al (2005) Morphologic studies on the ageing and osteoarthritis of the articular cartilage in C57 black mice. J Orthopedic Surg 13(1):8–18.Google Scholar
  77. 77.
    Yu LP, Smith GN, Brandt KD, et al (1996) Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthitis Rheum 35:1150–1159.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2007

Authors and Affiliations

  • Alison M. Bendele

There are no affiliations available

Personalised recommendations