Abstract
Although by this stage the utility of alprostadil in erectile dysfunction (ED) was well known and the drug was widely used, there had been no long-term analysis of efficacy and safety. This trial showed that efficacy was maintained over a 4-year period and that there was no tachyphylaxis.
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7.1 Key Trial References
7.1.1 Major Publication
Porst H, Buvat J, et al. Intracavernous Alprostadil Alfadex — an effective and well tolerated treatment for erectile dysfunction. Results of a long-term European study. Int J Impot Res 10:225–231, 1998.
7.1.2 Other Important Publications
The long-term safety of alprostadil (prostaglandin — E1) in patients with erectile dysfunction. The European Alprostadil Study Group. Br J Urol 82(4):538–543, 1998.
Purvis K, Egdetveit I, Christiansen E. Intracavernosal therapy for erectile failure — impact of treatment and reasons for drop-out and dissatisfaction. Int J Impot Res 11(5):287–299, 1999.
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(2007). An Elegant Long-Term Trial Assessing the Clinical Profile of Intracavernosal Prostaglandin E1 (Alprostadil). In: Key Clinical Trials in Erectile Dysfunction. Springer, London. https://doi.org/10.1007/978-1-84628-428-1_7
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DOI: https://doi.org/10.1007/978-1-84628-428-1_7
Publisher Name: Springer, London
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