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Defining the Therapeutic Ratio for Intracavernosal Administration of Prostaglandin E1 (Alprostadil)

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Key Clinical Trials in Erectile Dysfunction
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Abstract

Although intracavernosal administration of prostaglandin E1 (PGE1) had been performed since the mid-1980s, few data were available from reliable clinical trials. This study provided a rigorous clinical rationale for the continued use of intracorporal PGE1.

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6.1 Key Trial References

6.1.1 Major Publication

  • Linet O, Ogrinc F. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. N Engl J Med 334:873–877, 1996.

    Article  PubMed  CAS  Google Scholar 

6.1.2 Other Important Publications

  • Linet O, Neff L. Intracavernous prostaglandin E1 in erectile dysfunction. Clin Invest 72:139–149, 1989.

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  • Brock G, Tu L, Linet O. Return of spontaneous erection during long-term intracavernosal alprostadil (Caverject) treatment. Urology 57(3): 536–541, 2001.

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© 2007 Springer-Verlag London Limited

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(2007). Defining the Therapeutic Ratio for Intracavernosal Administration of Prostaglandin E1 (Alprostadil). In: Key Clinical Trials in Erectile Dysfunction. Springer, London. https://doi.org/10.1007/978-1-84628-428-1_6

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  • DOI: https://doi.org/10.1007/978-1-84628-428-1_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-427-4

  • Online ISBN: 978-1-84628-428-1

  • eBook Packages: MedicineMedicine (R0)

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