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Tumors: Cerebral Metastases and Lymphoma

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Tumor Neurosurgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

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Abstract

This chapter focuses on two intracranial neoplasms: cerebral metastases and lymphoma. Cerebral metastases are the most common form of intracranial tumor and often require treatment with surgery and/or radiation. Improvement of neurological function occurs in 50–75% of patients. Primary lymphoma represents about 1% of intracranial tumors and is highly responsive to chemotherapy and whole brain radiotherapy.

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References

  1. Johnson JD, Young B. Demographics of brain metastasis. Neurosurg Clin N Am 1996;7:337–44.

    CAS  PubMed  Google Scholar 

  2. Posner JB, Chernik NL. Intracranial metastasis from systemic cancer. Advances in Neurology 1978; 19: 579–92.

    CAS  PubMed  Google Scholar 

  3. Posner JB. Neurologic complications of cancer. Contemporary Neurology series. Volume 45. Phildelphia: Davis, 1995.

    Google Scholar 

  4. Das A, Hochberg FH. Clinical presentation of intracranial metastases. Neurosurg Clin N Am 1996;7:377–91.

    CAS  PubMed  Google Scholar 

  5. Schaefer PW, Budzik RF, Gonzalez GG. Imaging of cerebral metastases. Neurosurg Clin N Am 1996;7:393–423.

    CAS  PubMed  Google Scholar 

  6. Murray K, Kun L, Cox J. Primary malignant lymphoma of the central nervous system: results of treatment of 11 cases and review of the literature. J Neurosurg 1987;65:600–7.

    Google Scholar 

  7. Patchell RA, Tibbs PA, Walsh JW et al. A randomized trial of surgery in the treatment of single metastases to the brain. NEJM 1990;322:494–500.

    CAS  PubMed  Google Scholar 

  8. Chin L, Zee C, Apuzzo M. Special considerations in point stereotactic procedures. In: Apuzzo M, editor. Brain surgery. New York: Churchill Livingstone, 1993;414–25.

    Google Scholar 

  9. Cairncross JG, Kim J, Posner JB. Radiation therapy for brain metastases. Ann Neurol 1980;7:529–41.

    Article  CAS  PubMed  Google Scholar 

  10. Paleologos NA, Imperatu JP, Vick NA. Brain metastasis: effects of radiotherapy on longterm survivors. Neurology 1991;41(Suppl. 1):129.

    Google Scholar 

  11. Alexander E III, Moriarity TM, Davis RB, Wen PY, Fine HA, Black PM et al. Stereotactic radiosurgery for the definitive nininvasive treatment of brain metastases. J Natl Cancer Institute 1995;87:34–40.

    Article  Google Scholar 

  12. Lang FF, Sawaya R. Surgical management of cerebral metastases. Neurosurg Clin N Am 1996;7:459–84.

    CAS  PubMed  Google Scholar 

  13. Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ et al. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 1998;280:1485–9.

    Article  CAS  PubMed  Google Scholar 

  14. Sundaresan N, Sachdev VP, DiGiacinto GV, Hughes JEO. Reoperation for brain metastases. J Clin Oncol 1988;6:1625–9.

    CAS  PubMed  Google Scholar 

  15. Cooper JS, Steinfeld AD, Lerch I A. Cerebral metastases: value of reirradiation in selected patients. Radiology 1990;174:883–5.

    CAS  PubMed  Google Scholar 

  16. Hochberg FH, Miller DC. Primary central nervous system lymphoma. J Neurosurg 1988;68:835–53.

    Article  CAS  PubMed  Google Scholar 

  17. Corn BW, Marcus SM, Topham A et al. Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000? Cancer 1997;79:2409–13.

    Article  CAS  PubMed  Google Scholar 

  18. Miller DC, Hochberg FH, Harris NL et al. Pathology with clinical correlations of primary central nervous system non-Hodgkin’s lymphoma: the Massachusetts General Hospital experience 1958–1989. Cancer 1994;74: 1383–97.

    Article  CAS  PubMed  Google Scholar 

  19. Antoniri A, De Rossi G, Ammassari A. Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphoma. J Clin One 1999;17:554–60.

    Google Scholar 

  20. DeAngelis LM. Current management of primary central nervous system lymphoma. Oncology 1995;9:63–71.

    CAS  PubMed  Google Scholar 

  21. Remick SC, Diamond C, Migliozzi JA et al. Primary central nervous system lymphoma in patients with and without the acquired immune deficiency syndrome: a retrospective analysis and review of the literature. Medicine 1990;69:345–60.

    Article  CAS  PubMed  Google Scholar 

  22. Leibel SA, Sheline GE. Radiation therapy for neoplasms of the brain. J Neurosurg 1987;66:1–22.

    Article  CAS  PubMed  Google Scholar 

  23. Nelson DF, Martz KL, Bonner H et al. Non-Hodgkin’s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 1992;23:9–17.

    CAS  PubMed  Google Scholar 

  24. Goldstein JD, Dickson DW, Moser FG et al. Primary central nervous system lymphoma in acquired immune deficiency syndrome: a clinical and pathologic study with results of treatment with radiation. Cancer 1991;67:2756–65.

    Article  CAS  PubMed  Google Scholar 

  25. Bessell EM, Punt J, Firth J et al. Primary Non-Hodgkin’s lymphoma of the central nervous system: Phase II study of chemotherapy (BVAM) prior to radiotherapy. Clin Oncol 1991;3:193–8.

    Article  CAS  Google Scholar 

  26. Liang BC, Grant R, Junck L et al. Primary central nervous system lymphoma: treatment with multiagent systemic and intrathecal chemotherapy with radiation therapy. Int J Oncol 1993;3:1001–4.

    Google Scholar 

  27. LaChance DH, Brizel DM, Gockerman JP et al. Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short duration response and multifocal intracerebral recurrence preceding radiotherapy. Neurology 1994;44:1721–7.

    CAS  PubMed  Google Scholar 

  28. Glass J, Gruber ML, Cher L, et al. Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long term outcome. J Neurosurg 1994;81:188–95.

    Article  CAS  PubMed  Google Scholar 

  29. Glass J, Shustik C, Hochberg FH, et al. Therapy of primary central nervous system lymphoma with pre-irradiation methotrexate, cyclophosphamide, doxorubicin, vincristine, and dexamethasone (MCHOD). J Neurooncol 1996;30:257–65.

    Article  CAS  PubMed  Google Scholar 

  30. Schultz C, Scott C, Sherman W, et al. Preirradiation chemotherapy with cyclophosphamide, doxorubicin, vincristine, and dexamethasone for primary CNS lymphomas: intial report of radiation therapy oncology group protocol 88-06. J Clin One 1996;14:556–64.

    CAS  Google Scholar 

  31. Brada M, Hjiyiannakis D, Hines F, et al. Short intensive primary chemotherapy and radiotherapy in sporadic primary CNS lymphoma (PCL). Int J Radiat Oncol Biol Phys 1998;40:1157–62.

    CAS  PubMed  Google Scholar 

  32. Abrey LE, DeAngelis LM, Yahalom J. Long-term survival in primary CNS lymphoma. J Clin One 1998; 16: 859–63.

    CAS  Google Scholar 

  33. Hiraga S, Arita N, Ohnishi T, et al. Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas. J Neurosurg 1999;91:221–30.

    Article  CAS  PubMed  Google Scholar 

  34. Shibamoto Y, Tsutsui K, Dodo Y, et al. Improved survival rate in primary intracranial lymphoma treated by high-dose radiation and systemic vincristine-doxorubicin-cyclophosphamide-prednisolone chemotherapy. Cancer 1990;65:1907–12.

    Article  CAS  PubMed  Google Scholar 

  35. Chamberlain MC, Levin VA. Primary central nervous system lymphoma: a role for adjuvant chemotherapy. J Neuro-oncol 1992;14:271–5.

    Article  CAS  Google Scholar 

  36. Rosenthal MA, Sheridan WP, Green MD et al. Primary cerebral lymphoma: an argument for the use of adjunctive systemic chemotherapy. Aust N Z J Surg 1993;63:30–2.

    Article  CAS  PubMed  Google Scholar 

  37. Neuwelt EA, Goldman DL, Dahlborg SA et al. Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function. J Clin One 1991;9:1580–90.

    CAS  Google Scholar 

  38. Cher L, Glass J, Harsh GR et al. Therapy of primary CNS lymphoma with methotrexate-based chemotherapy and deferred radiotherapy: preliminary results. Neurology 1996;46:1757–9.

    CAS  PubMed  Google Scholar 

  39. Freilich RJ, Delattre JY, Monjour A et al. Chemotherapy without radiation mtherapy as initial treatment for primary CNS lymphoma in older patients. Neurology 1996;46:435–9.

    CAS  PubMed  Google Scholar 

  40. Sandor V, Stark-Vanes V, Pearson D et al. Phase II trial of chemotherapy alone for primary CNS and intraocular lymphoma. J Clin Oncol 1998;16:3000–6.

    CAS  PubMed  Google Scholar 

  41. Pollack IF, Lunsford LD, Flickinger JC et al:. Prognostic factors in the diagnosis and treatment of primary central nervous system lymphoma. Cancer 1989;63: 939–47.

    Article  CAS  PubMed  Google Scholar 

  42. Brada M, Dearnaley D, Horwich A et al. Management of primary cerebral lymphoma with initial chemotherapy: preliminary results and comparison with patients treated with radiotherapy alone. Int J Radiat Oncol Biol Phys 1990;18:787–92.

    CAS  PubMed  Google Scholar 

  43. Chamberlain MC, Levin VA. Adjuvant chemotherapy for primary lymphoma of the central nervous systyem. Arch Neurol 1990;97:1113–6.

    Google Scholar 

  44. DeAngelis LM, Yahalom J, Thaler H et al. Combined modality therapy for primary CNs lymphoma. J Clin One 1992;10:635–43.

    CAS  Google Scholar 

  45. Chamberlain MC. Long survival in patients with acquired immune deficiency syndrome related primary central nervous system lymphoma. Cancer 1994;73: 1728–30.

    Article  CAS  PubMed  Google Scholar 

  46. Blay J-Y, Conroy T, Chevreau C et al. High-dose methotrexate for the treatment of primary cerebral lymphomas: an analysis of survival and late neurologic toxicity in a retrospective series. J Clin One 1998;16:864–71.

    CAS  Google Scholar 

  47. Liang RH S, Woo EKW, Yu Y et al. Central nervous system involvement in non-Hodgkin’s lymphoma. Eur J Clin One 1989;25:703–10.

    Article  CAS  Google Scholar 

  48. Perez-Soler R, Smith TL, Cabanillas F. Central nervous system prophylaxis with combined intravenous and intrathecal methotrexate in diffuse lymphoma of aggressive histologic type. Cancer 1986;57:971–7.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Neurosurgery Service Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Sepideh Amin-Hanjani MD

  2. Neurosurgical Oncology Stanford Medical School, Stanford University, Stanford, CA, USA

    Griffith R. Harsh IV MD, MA, MBA

Authors
  1. Sepideh Amin-Hanjani MD
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  2. Griffith R. Harsh IV MD, MA, MBA
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Editor information

Editors and Affiliations

  1. South West Neurosurgery Centre, Derriford Hospital, Plymouth, UK

    Anne J. Moore MB BS, BSc, FRCS

  2. The Seattle Neuroscience Institute, Seattle, WA, USA

    David W. Newell

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© 2006 Springer-Verlag London Limited

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Amin-Hanjani, S., Harsh, G.R. (2006). Tumors: Cerebral Metastases and Lymphoma. In: Moore, A.J., Newell, D.W. (eds) Tumor Neurosurgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-84628-294-2_16

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  • DOI: https://doi.org/10.1007/978-1-84628-294-2_16

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-291-1

  • Online ISBN: 978-1-84628-294-2

  • eBook Packages: MedicineMedicine (R0)

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