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The Respiratory System

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Abstract

Induced lesions of the respiratory tract are described on an organ-by-organ basis with illustrations. Both nonneoplastic and neoplastic changes of the various regions are covered. Examples of test articles causing different lesions are provided. Lesions of the upper respiratory tract in inhalation safety studies are described in some detail, with particular reference to their significance. The mechanisms of toxicity in the various regions of the tract are discussed briefly, along with their relationship to the pathogenesis of these changes. The relevance of certain mechanical and physiological features to the development of these lesions also is mentioned.

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Authors and Affiliations

  1. Consultant in Toxicology and Pathology, Cambridgeshire, UK

    Chirukandath Gopinath

  2. Huntingdon Life Sciences, Cambridgeshire, UK

    Vasanthi Mowat

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  1. Chirukandath Gopinath
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  2. Vasanthi Mowat
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Gopinath, C., Mowat, V. (2014). The Respiratory System. In: Atlas of Toxicological Pathology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-998-7_2

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  • DOI: https://doi.org/10.1007/978-1-62703-998-7_2

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-997-0

  • Online ISBN: 978-1-62703-998-7

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