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Adiposity and Kidney Disease

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Adipose Tissue and Adipokines in Health and Disease

Part of the book series: Nutrition and Health ((NH))

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Abstract

The prevalence of chronic kidney disease (CKD) is increasing worldwide and is a global public health challenge. Epidemiological data suggest a casual relationship with adiposity. Clinical and laboratory studies suggest that adiposity is involved in the development and progression of kidney disease. Mechanisms include adaptation to increased body mass, activation of sympathetic nervous and renin–angiotensin systems, insulin resistance, hyperlipidemia, and release of adipokines. Kidney disease may also effect the association of adiposity with cardiovascular outcomes. In this chapter, the interactions of adiposity and kidney disease and their effects on clinical outcomes are examined.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, University of Utah Medical Center, 85 North Medical Drive, Salt Lake City, UT, 84112, USA

    Josephine D. Abraham M.D., M.P.H.

  2. Division of Nephrology and Hypertension, Veterans Affairs Salt Lake City Healthcare System, University of Utah, 85 North Medical Drive East, Salt Lake City, UT, 84112, USA

    Srinivasan Beddhu M.D.

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  1. Josephine D. Abraham M.D., M.P.H.
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Correspondence to Srinivasan Beddhu M.D. .

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Editors and Affiliations

  1. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA

    Giamila Fantuzzi

  2. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA

    Carol Braunschweig

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Abraham, J.D., Beddhu, S. (2014). Adiposity and Kidney Disease. In: Fantuzzi, G., Braunschweig, C. (eds) Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-770-9_20

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  • DOI: https://doi.org/10.1007/978-1-62703-770-9_20

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