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Genital Herpes

  • D. Gene Parks
Chapter
Part of the Current Clinical Practice book series (CCP)

Abstract

Herpes simplex virus (HSV) has a long and confusing history. More than 2,500 years ago, Hippocrates first used the word “herpes,” derived from the Greek word “to creep,” to describe how the lesions of this contagious ulcerative disease seemed to creep or crawl along the skin (Herpes 8:23–27, 2001). Galen first noted that recurrences develop at the same anatomic site. However, over time, the word herpes was used to describe many skin conditions from lupus to zoster. The definition of herpes (particularly oral lesions) became more rigorous in the seventeenth century. In the 1830s, recurrent genital herpes was described and 60 years later was identified as a “vocational disease”—a sexually transmitted infection (STI). The virus itself was not identified until the 1950s. In 1971, it was proposed that two different types of HSV caused infection. HSV-1 commonly causes labial or pharyngeal infection, and transmission is primary by nongenital contact. HSV-2 typically affects the genital area and is transmitted by intimate sexual contact. However, both viruses are capable of causing either genital or oral-pharyngeal infections that appear identical on examination. In the United States, HSV infection is one of the most common STIs and is the leading cause of genital ulcers.

Keywords

Human Immunodeficiency Virus Herpes Simplex Virus Herpes Simplex Virus Type Sexually Transmitted Infection Genital Herpes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Roizman B, Whitley RJ. The nine ages of herpes simplex virus. Herpes. 2001;8:23–7.PubMedGoogle Scholar
  2. 2.
    Xu F, Sternberg MR, Kottiri BJ, et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA. 2006;296(8):964–73.PubMedCrossRefGoogle Scholar
  3. 3.
    Yeung-Yue KA, Brentjens MH, Lee PC, Tyring SK. Herpes simplex viruses 1 and 2. Dermatol Clin. 2002;20:249–66.PubMedCrossRefGoogle Scholar
  4. 4.
    Mertz GJ, Benedetti J, Ashley R, Selke SA, Corey L. Risk factors for the sexual transmission of genital herpes. Ann Intern Med. 1992;116:197–202.PubMedCrossRefGoogle Scholar
  5. 5.
    Corey L, Wald A, Patel R, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004;350:11–20.PubMedCrossRefGoogle Scholar
  6. 6.
    National Institute of Allergy and Infectious Diseases. Workshop summary: scientific evidence on condom effectiveness for sexually transmitted disease (STD) prevention. Washington, DC: National Institutes of Health, Department of Health Services; 2001. Available from: http://www.niaid.nih.gov/dmid/stds/condomreport.pdf. Accessed 4 June 2005.
  7. 7.
    World Health Organization. Global prevalence and incidence of selected curable sexually transmitted infections: overview and estimates. Geneva: World Health Organization; 2001. Available from: http://www.who.int/emc-documents/STIs/whocdscsredc200110c.html. Accessed 10 July 2005.
  8. 8.
    Schacker T. The role of HSV in the transmission and progression of HIV. Herpes. 2001;8:46–9.PubMedGoogle Scholar
  9. 9.
    Schacker T, Ryncarz AJ, Goddard J, Diem K, Shaughnessy M, Corey L. Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. JAMA. 1998;280:61–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Mole L, Ripich S, Margolis D, Holodniy M. The impact of active herpes simplex virus infection on human immunodeficiency virus load. J Infect Dis. 1997;176:766–70.PubMedCrossRefGoogle Scholar
  11. 11.
    Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis. 2002;185:45–52.PubMedCrossRefGoogle Scholar
  12. 12.
    Wald A. Herpes simplex virus type 2 transmission: risk factors and virus shedding. Herpes. 2004;11:130A–7.PubMedGoogle Scholar
  13. 13.
    Wald A, Langenberg AG, Link K, et al. Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women. JAMA. 2001;285:3100–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Cherpes TL, Meyn LA, Krohn MA, Hillier SL. Risk factors for infection with herpes simplex virus type 2: role of smoking, douching, uncircumcised males, and vaginal flora. Sex Transm Dis. 2003;30:405–10.PubMedCrossRefGoogle Scholar
  15. 15.
    Langenberg AG, Corey L, Ashley RL, Leong WP, Straus SE. A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. N Engl J Med. 1999;341:1432–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Lafferty WE, Downey L, Celum C, Wald A. Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention. J Infect Dis. 2000;181:1454–7.PubMedCrossRefGoogle Scholar
  17. 17.
    Wald A, Zeh J, Selke S, et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med. 2000;342:844–50.PubMedCrossRefGoogle Scholar
  18. 18.
    Wald A, Corey L, Cone R, Hobson A, Davis G, Zeh J. Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. J Clin Invest. 1997;99:1092–7.PubMedCrossRefGoogle Scholar
  19. 19.
    Bryson Y, Dillon M, Bernstein DI, Radolf J, Zakowski P, Garratty E. Risk of acquisition of genital herpes simplex virus type 2 in sex partners of persons with genital herpes: a prospective couple study. J Infect Dis. 1993;167:942–6.PubMedCrossRefGoogle Scholar
  20. 20.
    Koelle DM, Benedetti J, Langenberg A, Corey L. Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes. Ann Intern Med. 1992;116:433–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Benedetti J, Corey L, Ashley R. Recurrence rates in genital herpes after symptomatic first episode infection. Ann Intern Med. 1994;121:847–54.PubMedCrossRefGoogle Scholar
  22. 22.
    Kimberlin DW, Rouse DJ. Clinical practice. Genital herpes. N Engl J Med. 2004;350:1970–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Corey L, Adams HG, Brown ZA, Holmes KK. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med. 1983;98:958–72.PubMedCrossRefGoogle Scholar
  24. 24.
    Patel R, Boselli F, Cairo I, Barnett G, Price M, Wulf HC. Patients’ perspectives on the burden of recurrent genital herpes. Int J STD AIDS. 2001;12:640–5.PubMedCrossRefGoogle Scholar
  25. 25.
    Sweet RL, Gibbs RS. Herpes simplex virus infection. In: Sweet RL, Gibbs RS, editors. Infectious diseases of the female genital tract. 4th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2002. p. 101–17.Google Scholar
  26. 26.
    Kessler HA, Baker DA, Brown ZA, Leone PA. Herpesvirus management: special considerations for the female patient. A monograph based on a symposium held May 6, New York, NY: New World Health; 2002.Google Scholar
  27. 27.
    Ebel C, Wald A. Managing herpes: how to live and love with a chronic STD. 3rd ed. Research Park Triangle, NC: American Social Health Association; 2002.Google Scholar
  28. 28.
    Kaufman RH, Gardner HL, Rawls WE, Dixon RE, Young RL. Clinical features of herpes genitalis. Cancer Res. 1973;33:1446–51.PubMedGoogle Scholar
  29. 29.
    Benedetti JK, Zeh J, Corey L. Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time. Ann Intern Med. 1999;131:14–20.PubMedCrossRefGoogle Scholar
  30. 30.
    Ashley-Morrow R, Krantz E, Wald A. Time course of seroconversion by HerpesSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2. Sex Transm Dis. 2003;30:310.PubMedCrossRefGoogle Scholar
  31. 31.
    Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines 2002. MMWR Recomm Rep. 2002;51:1–78.Google Scholar
  32. 32.
    Diaz-Mitoma F, Sibbald RG, Shafran SD, Boon R, Saltzman RL. Oral famciclovir for the suppression of recurrent genital herpes: a randomized controlled trial. Collaborative Famciclovir Genital Herpes Research Group. JAMA. 1998;280:887–92.PubMedCrossRefGoogle Scholar
  33. 33.
    Tyring SK, Baker D, Snowden W. Valacyclovir for herpes simplex virus infection: longterm safety and sustained efficacy after 20 years experience with acyclovir. J Infect Dis. 2002;186:S40–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Parks DG, Greenway FL, Pack AT. Prevention of recurrent herpes simplex type II infection with lithium carbonate. Med Sci Res. 1988;16:971–2.Google Scholar
  35. 35.
    Workowski KA, Berman S. Sexually transmitted disease treatment guidelines. 2010. Centers for Disease Control and Prevention. Division of STD Prevention National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention. MMWR Recomm Rep. 2010;59(RR-12):1–110.Google Scholar
  36. 36.
    Alexander L, Naisbett B. Patient and physician partnerships in managing genital herpes. J Infect Dis. 2002;186:S57–65.PubMedCrossRefGoogle Scholar
  37. 37.
    Brown ZA, Gardella C, Wald A, Morrow RA, Corey L. Genital herpes complicating pregnancy. Obstet Gynecol. 2005;106(4):845–56.PubMedCrossRefGoogle Scholar
  38. 38.
    Eskild A, Jeansson S, Stray-Pedersen B, Jenum PA. Herpes simplex virus type-2 infection in pregnancy: no risk of fetal death: results from a nested case–control study within 35,940 women. BJOG. 2002;109:1030–5.PubMedGoogle Scholar
  39. 39.
    Brown Z. Preventing herpes simplex virus transmission to the neonate. Herpes. 2004;11:175A–86.PubMedGoogle Scholar
  40. 40.
    Kimberlin DW. Neonatal herpes simplex infection. Clin Microbiol Rev. 2004;17(1):1–13.PubMedCrossRefGoogle Scholar
  41. 41.
    Smith JR, Cowan FM, Munday P. The management of herpes simplex virus infection in pregnancy. Br J Obstet Gynaecol. 1998;105:255–60.PubMedCrossRefGoogle Scholar
  42. 42.
    Watts DH, Brown ZA, Money D, et al. A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and cesarean delivery. Am J Obstet Gynecol. 2003;188:836–43.PubMedCrossRefGoogle Scholar
  43. 43.
    Thung SF, Grobman WA. The cost-effectiveness of routine antenatal screening for maternal herpes simplex virus-1 and -2 antibodies. Am J Obstet Gynecol. 2005;192:483–8.PubMedCrossRefGoogle Scholar
  44. 44.
    Baker D, Brown Z, Hollier LM, et al. Cost-effectiveness of herpes simplex virus type 2 serologic testing and antiviral therapy in pregnancy. Am J Obstet Gynecol. 2004;191:2074–84.PubMedCrossRefGoogle Scholar
  45. 45.
    American College of Obstetricians and Gynecologists. ACOG Practice Bulletin. Management of herpes in pregnancy. Number 8 October 1999. Clinical management guidelines for obstetrician-gynecologists. Int J Gynaecol Obstet. 2000;68:165–73.Google Scholar
  46. 46.
    Sheffield JS, Hollier LM, Hill JB, Stuart GS, Wendel GD. Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review. Obstet Gynecol. 2003;102:1396–403.PubMedCrossRefGoogle Scholar
  47. 47.
    American College of Obstetricians and Gynecologists (ACOG). Management of herpes in pregnancy. Washington, DC: ACOG; 2007 (ACOG practice bulletin; no. 82).Google Scholar
  48. 48.
    Wald A, Langenberg AG, Krantz E, et al. The relationship between condom use and herpes simplex virus acquisition. Ann Intern Med. 2005;143(10):707–13.PubMedCrossRefGoogle Scholar
  49. 49.
    Rana RK, Pimenta JM, Rosenberg DM, et al. Sexual behaviour and condom use among individuals with a history of symptomatic genital herpes. Sex Transm Infect. 2006;82(1):69–74.PubMedCrossRefGoogle Scholar
  50. 50.
    National Institute of Allergy and Infectious Disease. Genital herpes. Washington DC: National Institutes of Health, Department of Health Services; 2011. Available from: http://www.niaid.nih.gov/topics/genitalherpes/research/researchreport.pdf. Accessed 24 May 2012.

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyDavid Geffen School of Medicine at UCLALos AngelesUSA

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