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Familial Aggregation of Blood Pressure

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Pediatric Hypertension

Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

Abstract

A number of family studies in the 1960s and 1970s showed that a familial tendency to high (or low) blood pressure is established early in life. However, it remained unclear whether shared genes or shared environment caused the blood pressure aggregation within families. Special study designs such as adoption or twin studies are necessary to effectively discriminate genetic from shared environmental influences. Furthermore, estimates of the relative influence of genetic and environmental factors derived from cross-sectional studies do not provide information on underlying genetic and environmental sources of continuity and change in the development of (high) blood pressure from childhood onward. The aim of this chapter, therefore, is to review the available literature of twin and family studies to address two issues: the potential causes of familial aggregation of blood pressure and the age dependency of genetic or environmental sources of blood pressure variation (and covariation) within and between families.

XW was supported in part by grants from the National Heart Lung and Blood Institute (HL086530) and the American Heart Association (0730156N)

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Authors and Affiliations

  1. Georgia Prevention Institute, Department of Pediatrics, Georgia Regents University, Augusta, GA, USA

    Xiaoling Wang M.D., Ph.D.

  2. Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 30.001, 9700 RB, Groningen, The Netherlands

    Harold Snieder Ph.D.

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  1. Xiaoling Wang M.D., Ph.D.
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Correspondence to Harold Snieder Ph.D. .

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Editors and Affiliations

  1. University of Washington, Division of Pediatrics, Seattle Children's Hospital, Sand Point Way NE. 4800, Seattle, 98105, Washington, USA

    Joseph T. Flynn

  2. Harvard Medical School, Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Julie R. Ingelfinger

  3. Global Clinical Research, Bristol-Myers Squibb, Route 206 & Provinceline Road, Princeton, 08543, New Jersey, USA

    Ronald J. Portman

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Wang, X., Snieder, H. (2013). Familial Aggregation of Blood Pressure. In: Flynn, J., Ingelfinger, J., Portman, R. (eds) Pediatric Hypertension. Clinical Hypertension and Vascular Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-490-6_14

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