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New Advances on Disease Biomarkers and Molecular Targets in Biomedicine pp 231–242Cite as

Mesoporous Silica Nanoparticles for Cancer Therapy

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Abstract

The pursuit of better drug delivery systems for cancer therapy has remained hot areas of research. In this chapter, we review the use of mesoporous silica nanoparticles (MSNs), a particular type of nanomaterials as chemotherapeutics/biological molecules delivery vehicle for cancer treatment. MSNs are synthesized with orderly arranged mesopores of tunable sizes, which endow them with unique structural and functional advantages that can be utilized for drug loading. MSNs have been shown to deliver chemotherapeutics, DNA/siRNA and proteins, or the combinations of drugs to cancer cells. The inner surface of the pores and the outer surface can be separately functionalized to realize effective drug loading and tumor targeting. MSNs offer an ideal platform for cancer drug delivery with promising hopes to be translated into clinical use.

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Authors and Affiliations

  1. Center of Medical Physics and Technology, Hefei Institute of Physical Science, Chinese Academy of Sciences, 350 Shushan Lake Road, Hefei, 230031, China

    Qian Liu Ph.D.

  2. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, P.R. China

    Weiliang Xia Ph.D.

Authors
  1. Qian Liu Ph.D.
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  2. Weiliang Xia Ph.D.
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Correspondence to Qian Liu Ph.D. or Weiliang Xia Ph.D. .

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Editors and Affiliations

  1. Faculty of Medicine Building, Department of Surgery, University of Hong Kong, Sassoon Road 21, Hong Kong, Hong Kong SAR

    Nikki P. Lee

  2. Center for Biomedical Research, Population Council, York Ave. 1230, NEW YORK, 10021, New York, USA

    C.Y. Cheng

  3. Yong Loo Lin School of Medicine, Department of Pharmacology and Departmen, National University of Singapore, Medical Drive 10, Singapore, 117597, Singapore

    John M. Luk

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Liu, Q., Xia, W. (2013). Mesoporous Silica Nanoparticles for Cancer Therapy. In: Lee, N., Cheng, C., Luk, J. (eds) New Advances on Disease Biomarkers and Molecular Targets in Biomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-456-2_13

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