Abstract
PPAR activity is modulated by several posttranslational modifications including phosphorylation, sumoylation, and ubiquitination. Furthermore, activity depends on intracellular localization of the receptor where nuclear localization leads to genomic effects, while cytosolic or cell membrane localization promotes nongenomic effects. Agonists of these receptors have been shown to produce effects that are PPAR independent.
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Youssef, J.A., Badr, M.Z. (2013). Molecular Aspects of PPAR Actions. In: Peroxisome Proliferator-Activated Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-420-3_7
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DOI: https://doi.org/10.1007/978-1-62703-420-3_7
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