Abstract
Using electron microscopy, microbodies were first discovered in 1954 in mouse renal cells by Rhodin (Afzelius 1965). Later in 1966, De Duve and Baudhuin were the first to isolate these organelles from rat liver and, based on biochemical studies, termed them peroxisomes (Schrader and Fahimi 2008). Peroxisomes were later found in all eukaryotic cells with the exception of mature erythrocytes and sperms (Schrader and Fahimi 2008; Fidaleo 2010). Although all peroxisomes have common metabolic pathways, unique cell- and/or tissue-specific peroxisomal functions may also exist. Future discovery of various peroxisomal marker proteins as well as more sensitive detection techniques such as mass spectrometry-based proteomics should provide insights toward better understanding of peroxisomal functions in different tissues and species (Islinger et al. 2010).
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Youssef, J.A., Badr, M.Z. (2013). History of PPAR Discovery. In: Peroxisome Proliferator-Activated Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-420-3_2
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DOI: https://doi.org/10.1007/978-1-62703-420-3_2
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