The Role of Polyphenols in Menopause

Part of the Nutrition and Health book series (NH)

Key Points

  • Menopause gives rise to an increase in the rate of the ageing process, thus causing premature ageing.

  • Oxidative stress occurs with menopause-related loss of oestrogens, this being responsible for premature ageing and much their of its associated physiological deterioration.

  • Polyphenols are a group of pigments widely distributed in plants and are responsible for colouring. Besides, they play a protective role due to their antioxidant activity.

  • Antioxidants, concretely polyphenols, can decrease the oxidative stress situation during menopause.

  • Diets rich in polyphenols, especially flavonoids such as soy food and tea, can decrease the physiological consequences and symptoms of menopause, improving the state of health.

  • Diets and supplements containing flavonoids such as isoflavones (phytoestrogens) could be an alternative to the pharmacological treatments frequently prescribed for menopausal and postmenopausal women.

  • Since polyphenols improve immune system function, which is a marker of health, biological age and a predictor of longevity, the ingestion of these antioxidants could aid in slowing down the ageing process during menopause.


Polyphenols Ageing Menopause Oxidative stress Antioxidants Immunosenescence 



Estrogen receptor




Glutathione peroxidase


Reduced glutathione


Oxidized glutathione


Hormonal replacement therapy


Mn-Superoxide dismutase


Reactive oxygen species


Tumor necrosis factor alpha



This work was supported by grants of the MCINN (BFU2008-04336; BFU2011-30336), Research Group of UCM (910379ENEROINN) and RETICEF (RD06/0013/0003) (RD12/0043/0018) (ISCIII).


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.San Rafael-Nebrija Health Sciences CentreNebrija UniversityMadridSpain
  2. 2.Department of Physiology (Animal Physiology II)Complutense University of MadridMadridSpain

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