The Role of Polyphenols in Menopause
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Menopause gives rise to an increase in the rate of the ageing process, thus causing premature ageing.
Oxidative stress occurs with menopause-related loss of oestrogens, this being responsible for premature ageing and much their of its associated physiological deterioration.
Polyphenols are a group of pigments widely distributed in plants and are responsible for colouring. Besides, they play a protective role due to their antioxidant activity.
Antioxidants, concretely polyphenols, can decrease the oxidative stress situation during menopause.
Diets rich in polyphenols, especially flavonoids such as soy food and tea, can decrease the physiological consequences and symptoms of menopause, improving the state of health.
Diets and supplements containing flavonoids such as isoflavones (phytoestrogens) could be an alternative to the pharmacological treatments frequently prescribed for menopausal and postmenopausal women.
Since polyphenols improve immune system function, which is a marker of health, biological age and a predictor of longevity, the ingestion of these antioxidants could aid in slowing down the ageing process during menopause.
KeywordsPolyphenols Ageing Menopause Oxidative stress Antioxidants Immunosenescence
Hormonal replacement therapy
Reactive oxygen species
Tumor necrosis factor alpha
This work was supported by grants of the MCINN (BFU2008-04336; BFU2011-30336), Research Group of UCM (910379ENEROINN) and RETICEF (RD06/0013/0003) (RD12/0043/0018) (ISCIII).
- 30.Maclennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004; (4):CD002978.Google Scholar
- 31.Lethaby AE, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2007; (4):CD001395.Google Scholar
- 41.Baeza I, Fdez-Tresguerres J, Ariznavarreta C, et al. Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats. Biogerontology. 2010;11(6):687–701.PubMedCrossRefGoogle Scholar