Abstract
There is no known pathophysiologic link and little in the literature written about the association between menopause and restless legs syndrome (RLS). RLS is known to occur in middle-to-late aged individuals, having a higher prevalence in women. Following this line of logic, it would raise the question of whether there is a relationship between RLS and menopause. It has been reported that up to 69 % of woman complain of worsening of restless leg symptoms following menopause. Estrogens are thought to be neuroprotective and the reduction of it in menopause may lead to RLS. It may be that with the onset of menopausal symptoms such as hot flashes disrupting sleep, a preexisting sleep disorder such as RLS, may become more evident.
This chapter was originally composed by Nancy S. Collins MD, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Department of Neurology, North Chicago, IL.
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Viola-Saltzman, M. (2013). Restless Legs Syndrome and Menopause. In: Attarian, H., Viola-Saltzman, M. (eds) Sleep Disorders in Women. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-324-4_17
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