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Contrast-Enhanced Ultrasonography

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Imaging and Focal Therapy of Early Prostate Cancer

Part of the book series: Current Clinical Urology ((CCU))

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Abstract

Ultrasound is the cornerstone for prostatic imaging and covers diagnostics, therapy monitoring, and follow-up. In the aspect of focal therapy, accurate prostate cancer localization is mandatory. Contrast-enhanced ultrasound (CEUS) is a promising imaging technique which has shown to greatly increase the chances to find prostate cancer in biopsies. At the moment, CEUS is only performed in expert centers because of difficult interpretation and steep learning curves. CEUS quantification techniques can make reliable and objective interpretation, with a high sensitivity, possible outside of expert centers. Focal therapy and active surveillance are increasingly used, but require to be supported by proper imaging techniques. CEUS seems a promising technique for real-time monitoring and follow-up of focal therapy treatment. In the near future, the use of targeted contrast agents will be a major breakthrough in the combat against prostate cancer. They show promising results regarding better visualization and longer lasting contrast enhancement of prostate cancer in in-vitro as well as in in-vivo animal experiments.

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Author information

Authors and Affiliations

  1. Department of Urology, AMC University Hospital, Meibergdreef 9, Amsterdam, 1105, AZ, The Netherlands

    M. Smeenge M.D., M. P. Laguna M.D., Ph.D. & J. J. M. C. H. de la Rosette M.D., Ph.D.

  2. Department of Electrical Engineering, Eindhoven University of Technology, Den Dolech 2, Eindhoven, 5612, AZ, The Netherlands

    M. Mischi Ph.D., M.Sc.

  3. Department of Urology/Electrical Engineering, AMC University Hospital/Eindhoven University of Technology, Meibergdreef 9, Amsterdam, 1105, AZ, The Netherlands

    H. Wijkstra M.Sc., Ph.D.

Authors
  1. M. Smeenge M.D.
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  2. M. Mischi Ph.D., M.Sc.
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  3. M. P. Laguna M.D., Ph.D.
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  4. J. J. M. C. H. de la Rosette M.D., Ph.D.
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  5. H. Wijkstra M.Sc., Ph.D.
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Corresponding author

Correspondence to H. Wijkstra M.Sc., Ph.D. .

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Editors and Affiliations

  1. , Department of Surgery, Duke Cancer Institute, Room 1089 Duke South, Durham, 27710, North Carolina, USA

    Thomas J. Polascik

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Smeenge, M., Mischi, M., Laguna, M.P., de la Rosette, J.J.M.C.H., Wijkstra, H. (2013). Contrast-Enhanced Ultrasonography. In: Polascik, T. (eds) Imaging and Focal Therapy of Early Prostate Cancer. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-182-0_12

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  • DOI: https://doi.org/10.1007/978-1-62703-182-0_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-181-3

  • Online ISBN: 978-1-62703-182-0

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