Epidemiology and Prognosis of T-Cell Lymphoma
T/NK-cell lymphoid neoplasms account for approximately 6 % of all lymphoid neoplasms. While the incidence rates of many B-cell lymphomas have begun to decline in the United States (US) in recent years, incidence rates for T-cell lymphomas have continued to rise. The causes of the majority of T-cell lymphomas remain unexplained. T-cell lymphomas comprise multiple subtypes and their distinct descriptive epidemiology—e.g., striking differences between incidences of T-cell lymphoma subtypes by age, over time and by race/ethnicity—likely reflect their distinct etiologies (e.g., celiac disease and extranodal T-cell lymphomas; human T-cell lymphotropic virus I (HTLV-1) and adult T-cell leukemia/lymphoma). Differences in T-cell lymphoma subtypes further extend to their clinical characteristics and care; they each have differential treatment, survival and prognosis. The rarity of T-cell lymphomas has historically posed challenges for furthering our understanding of these tumors, particularly as we now understand that each T-cell lymphoma subtype requires investigation independently. However, we expect important clues to emerge as on-going large international consortium efforts aim to accrue sufficient sample sizes of T-cell lymphomas and its subtypes for both etiological and prognostic studies.
KeywordsCeliac Disease Anaplastic Lymphoma Kinase Anaplastic Large Cell Lymphoma Mycosis Fungoides Lymphoid Neoplasm
We thank J. Daniel Carreon for guidance on descriptive statistics and graphical presentation.
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