The Role of Polyphenols in Skin Health

Part of the Nutrition and Health book series (NH)


Polyphenols are a unique group of phytochemicals that are present in a large number of fruits, vegetables, and other plant products. They are classified according to their chemical structure, which contains multiple linked phenol groups [1]. These compounds have powerful antioxidant properties that counteract harmful free radicals in the body. Nutrition has long been identified as a critical factor of health and well being, and the investigation into the costs and benefits of ingesting certain compounds has just begun; polyphenols in particular have been a topic of interest since the discovery that they may prevent or even reverse the effects of photoaging due to ultraviolet radiation [2]. Here, we explore the various types and properties of polyphenols, the deleterious effects of free radicals on skin health, and the possible protective and regenerative ability of dietary polyphenols.


Antioxidant Cancer Dietary polyphenols Flavonoids Oxidative stress Photoaging Resveratrol Ultraviolet radiation 


  1. 1.
    Bors W, Michel C, Stettmaier K. Structure-activity relationships governing antioxidant capacities of plant polyphenols. Methods Enzymol. 2001;335:166–80.PubMedCrossRefGoogle Scholar
  2. 2.
    Katiyar SK. Green tea prevents non-melanoma skin cancer by enhancing DNA repair. Arch Biochem Biophys. 2011;508(2):152–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Packer L. Flavonoids and other polyphenols. San Diego: Academic; 2001.Google Scholar
  4. 4.
    Haslam E. Plant polyphenols: vegetable tannins revisited. New York: Cambridge University Press; 1989.Google Scholar
  5. 5.
    Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 1998;56(11):317–33.PubMedCrossRefGoogle Scholar
  6. 6.
    Chong-Han K. Dietary lipophilic antioxidants: implications and significance in the aging process. Crit Rev Food Sci Nutr. 2010;50(10):931–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Huang M, Ho C, Lee CY. Phenolic compounds in food and their effects on health II: antioxidants and cancer prevention. Washington, DC: American Chemical Society; 1992.CrossRefGoogle Scholar
  8. 8.
    Baer D, Clevidence B, Cherry J, Novotny J, Rumpler W. Dietary modulation of markers of inflammation and oxidation as risk factors of chronic, degenerative diseases. Washington, DC: US Dept. of Agriculture, Agricultural Research Service; 2009. p. 5.Google Scholar
  9. 9.
    Robak J, Gryglewski RJ. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol. 1988;37(5):837–41.PubMedCrossRefGoogle Scholar
  10. 10.
    Waladkhani AR, Clemens MR. Preventive and therapeutic effects of dietary phytochemicals on cancer development. In: Watson RR, editor. Functional foods & nutraceuticals in cancer prevention. Ames, IA: Iowa State Press; 2008.Google Scholar
  11. 11.
    Sato M. Beneficial effect of moderate alcohol consumption to health: a review of recent results on wines. In: Shibamoto T, Terao J, Osawa T, editors. Functional foods for disease prevention I: fruits, vegetables, and teas. Washington, DC: American Chemical Society; 1997. p. 114–8.Google Scholar
  12. 12.
    Gan L. Therapeutic potential of sirtuin-activating compounds in Alzheimer’s disease. Drug News Perspect. 2007;20(4):233–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Moskowitz RJ. Components of skin. MedlinePlus web site. Updated 2010. Accessed September 15th, 2010
  14. 14.
    Skin Exposures and Effects. Centers for disease control and prevention: workplace safety & health topics web site. Updated 2010. Accessed September 20th, 2010
  15. 15.
    Kohen R. Skin antioxidants: their role in aging and in oxidative stress–new approaches for their evaluation. Biomed Pharmacother. 1999;53(4):181–92.PubMedCrossRefGoogle Scholar
  16. 16.
    Palmer DM, Kitchin JS. Oxidative damage, skin aging, antioxidants and a novel antioxidant rating system. J Drugs Dermatol. 2010;9(1):11–5.PubMedGoogle Scholar
  17. 17.
    Zaid MA, Afaq F, Syed DN, Dreher M, Mukhtar H. Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx. Photochem Photobiol. 2007;83:882–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Podda M, Grundmann-Kollmann M. Low molecular weight antioxidants and their role in skin ageing. Clin Exp Dermatol. 2001;26(7):578–82.PubMedCrossRefGoogle Scholar
  19. 19.
    Young AR. Cumulative effects of ultraviolet radiation on the skin: cancer and photoaging. Semin Dermatol. 1990;9(1):25–31.PubMedGoogle Scholar
  20. 20.
    Brash DE, Rudolph JA, Simon JA, et al. A Role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A. 1991;88(22):10124–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Meeran SM, Ahmed A, Tollefsbol TO. Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics. 2010;1(3–4):101–16.PubMedCrossRefGoogle Scholar
  22. 22.
    Zablotska LB, Chen Y, Graziano JH, et al. Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh. Environ Health Perspect. 2008;116(8):1056.PubMedCrossRefGoogle Scholar
  23. 23.
    Kandaswami C, Perkins E, Soloniuk DS, Drzewieckia G, Middleton Jr E. Antitproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. Cancer Lett. 1991;56(2):147–52.PubMedCrossRefGoogle Scholar
  24. 24.
    Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotechnol Biochem. 1999;63:896–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Katiyar SK, Mukhtar H. Green tea polyphenol (−)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. J Leukoc Biol. 2001;69(5):719–26. Society for Leukocyte Biology. Web.PubMedGoogle Scholar
  26. 26.
    Leung LK, Su Y, Chen R, Zhang Z, Huang Y, Chen Z. Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutr. 2001;131:2248–51.PubMedGoogle Scholar
  27. 27.
    Goldbohm RA, Hertog MG, Brants HA, van Poppel G, van den Brandt PA. Consumption of black tea and cancer risk: a prospective cohort study. J Natl Cancer Inst. 1996;88(2):93–100.PubMedCrossRefGoogle Scholar
  28. 28.
    Hung CF, Lin YK, Huang ZR, Fang JY. Delivery of resveratrol, a red wine polyphenol, from solutions and hydrogels via the skin. Biol Pharm Bull. 2008;31(5):955–62.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.University of ArizonaTucsonUSA
  2. 2.Health Sciences CenterMel and Enid Zuckerman College of Public Health, and School of Medicine, University of ArizonaTucsonUSA

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