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Regenerative Medicine and Cell Therapy pp 155–168Cite as

Pancreatic Reprogramming

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Hidden behind the hype of prospective stem cell-based approaches to treat human disease, reprogramming techniques have finally entered the landscape of regenerative medicine and are quickly becoming one of the most exciting and powerful weapons in the field. In the context of pancreatic regeneration, the reprogramming of non-endocrine adult tissues to cells with phenotypes resembling to those of the hormone-producing cells of the islets of Langerhans is a fertile and dynamic area of research. Here we analyze two of the most studied sources of reprogrammable cells, namely the liver and the acinar compartment of the pancreas. Several groups have now established that the ectopic expression of master pancreatic regulators such as Pdx1, MafA, Ngn3, or BETA2/NeuroD can result in variable degrees of reprogramming toward pancreatic endocrine fates, leading to insulin production in vitro, and reversal of hyperglycemia in vivo. The state of the art and clinical prospects of these novel approaches are discussed in the following chapter.

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Acknowledgments

JDB acknowledges the funding of the JDRF, the NIH and the Diabetes Research Institute Foundation (DRIF)

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  1. Diabetes Research Institute, University of Miami, Miami, FL, USA

    Juan Domínguez-Bendala

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  1. Juan Domínguez-Bendala
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Correspondence to Juan Domínguez-Bendala .

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  1. Royan Institute, Department of Developmental Biology, University of Science and Culture, PO Box 19395-4644, Tehran, Iran

    Hossein Baharvand

  2. , Regenerative Medicine, Royan Institute for Stem Cell Biology an, P.O. Box: 19395-4644, Tehran, Iran

    Nasser Aghdami

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Domínguez-Bendala, J. (2013). Pancreatic Reprogramming . In: Baharvand, H., Aghdami, N. (eds) Regenerative Medicine and Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-098-4_8

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