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Development of Biological Approaches to Improve Muscle Healing After Injury and Disease

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Regenerative Medicine and Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Unique among adult tissues, skeletal muscle possesses a robust regeneration capacity dependent upon satellite cells (SC), the professional muscle stem cell. SCs are normally quiescent in a niche located within the basal lamina but outside the muscle membrane, or sarcolemma. Activated SCs proliferate and migrate to the site of injury. Through asymmetric division, a portion of SCs return to quiescence while daughter cells committed to the myogenic lineage, termed myoblasts, fuse and eventually form new muscle fibers. Yet, despite this potential, severely damaged muscle requires medical intervention. In addition to injuries resulting from blunt trauma, work, or sports-related accidents, there are a number of muscle diseases, both inherited, and acquired. At this time, there are no pharmaceutical drugs that can be used to effectively accelerate muscle healing following injury. Here, we discuss new biological approaches to improve muscle healing such as growth factor delivery, myoblast transfer therapy, stem cell-based therapy, gene therapy, and combining biological therapeutics.

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Authors and Affiliations

  1. Stem Cell Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jonathan D. Proto & Johnny Huard

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  1. Jonathan D. Proto
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  2. Johnny Huard
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Correspondence to Johnny Huard .

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Editors and Affiliations

  1. Royan Institute, Department of Developmental Biology, University of Science and Culture, PO Box 19395-4644, Tehran, Iran

    Hossein Baharvand

  2. , Regenerative Medicine, Royan Institute for Stem Cell Biology an, P.O. Box: 19395-4644, Tehran, Iran

    Nasser Aghdami

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Proto, J.D., Huard, J. (2013). Development of Biological Approaches to Improve Muscle Healing After Injury and Disease. In: Baharvand, H., Aghdami, N. (eds) Regenerative Medicine and Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-098-4_6

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