Regenerative Therapies for Liver Diseases

  • Amar Deep Sharma
  • Ina Rittelmeyer
  • Tobias Cantz
  • Michael Ott
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

The liver responds to injury or tissue loss by rapid restoration of the original cell mass. The high regenerative capacity is sufficient to restore normal volume and function in most forms of acute liver injury and medical interventions are not required. For the development of regenerative therapies a fundamental understanding of these regenerative principles in the liver is required. In this chapter, we discuss the emerging medical approaches for acute liver failure, chronic liver failure, and hereditary liver diseases, which are based on technologies, such as (stem) cell therapy, tissue engineering, bio-artificial devices or gene therapies.

Keywords

Liver Regeneration Acute Liver Failure Bioartificial Liver Hepatocyte Transplantation Transplant Bone Marrow Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Amar Deep Sharma
    • 1
  • Ina Rittelmeyer
    • 2
    • 3
  • Tobias Cantz
    • 1
  • Michael Ott
    • 2
    • 3
  1. 1.Junior Research Group “Stem Cell Biology”Cluster of Excellence REBIRTH, Hannover Medical SchoolHannoverGermany
  2. 2.Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannoverGermany
  3. 3.TWINCORE, Centre for Experimental and Clinical Infection Research, A joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI)HannoverGermany

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