Cell Therapy for Neurodegenerative Disorders

Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

The last decade has seen tremendous progress in stem cell biology, targeted genome editing, bioengineering, and systems neuroscience supporting the notion that cell therapy of various disorders of the central nervous system (CNS) may become clinical reality in the near future. In particular, the advent of induced pluripotent stem (iPS) cells and access to large quantities of patient- and disease-specific cellular material offers unique opportunities for developmental biology and regenerative medicine. It is now possible to investigate the molecular underpinnings of monogenic and complex human diseases using stem cell-derived neural phenotypes. Molecular insights from such studies will leverage the development of diagnostic tools, biomarkers, drugs, and cell replacement with the ultimate goal to halt or reverse the course of devastating maladies. In this book chapter, I shall discuss the opportunities and emerging challenges of stem cell-based therapies and highlight common neurological diseases that may benefit from such iatrogenic interventions.

Keywords

Amyotrophic Lateral Sclerosis Cell Therapy Spinal Muscular Atrophy Human Embryonic Stem Cell Pluripotent Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

I.S. was a fellow of the California Institute for Regenerative Medicine (CIRM) and was supported by the International Bipolar Foundation.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Sanford-Burnham Medical Research InstituteLa JollaCA

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