Genitourinary Dermatology

  • Emily C. Keller
  • Kenneth J. TomeckiEmail author
Part of the Current Clinical Urology book series (CCU)


Skin disease of the genitourinary tract assumes a variety of clinical presentations and exists on a continuum from facticial disease to transmissible infections to benign growths and malignant neoplasms. A differential diagnosis can be broad, but most diseases fall into one of the following categories: fixed drug eruption, allergic/irritant contact dermatitis, infection, neoplasia/tumor, trauma, papulosquamous/systemic, and balanitis. To the untrained eye, these dermatoses can appear very worrisome and may evoke an unnecessary sense of urgency and anxiety in the physician and patient. Common dermatoses, infections (sexual, bacterial, fungal, etc.), benign growths, and malignancies are presented below. Diagnostic approaches consist of visual diagnosis, biopsy, superficial skin scrapings, and imaging. Treatment options for genital dermatoses include topical and oral steroids, topical and oral antibiotics, behavior modification, surgical interventions, lasers, and emotional support.

Diagnoses can be delayed if guilt and embarrassment inhibit patients from seeking medical attention. Regardless of the location, physicians should persevere in obtaining a history and performing a physical exam, employing an interdisciplinary approach if necessary.


Contact Dermatitis Topical Corticosteroid Lichen Planus Female Genital Mutilation Hidradenitis Suppurativa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Excerpts reprinted from Enriquez A, Tomecki KJ. Dermatological Diseases Affecting the Genitourinary System. In: Potts JM, Ed. Genitourinary Pain And Inflammation Diagnosis And Management. Humana Press. Totowa, NJ;2008: 57–76. With permission from Springer Science + Business Media.


  1. 1.
    English 3rd HC, Laws RA, Keough GC, Wilde JL, Foley JP, Elston DM. Dermatoses of the glans penis and prepuce. J Am Acad Dermatol. 1997;37(1):1–24 [quiz 25–6].PubMedCrossRefGoogle Scholar
  2. 2.
    Bhate K, Landeck L, Gonzalez E, Neumann K, Schalock PC. Genital contact dermatitis: a retrospective analysis. Dermatitis. 2010;21(6):317–20.PubMedGoogle Scholar
  3. 3.
    Vermaat H, Smienk F, Fustemeyer T, Bruynzeel DP, Kirtschig G. Anogenital allergic contact dermatitis, the role of spices and flavour allergy. Contact Dermatitis. 2008;59:233–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Hindson TC. Studies in contact dermatitis. XVI. Contraceptives. Trans St Johns Hosp Dermatol Soc. 1966;52(1):1–9.PubMedGoogle Scholar
  5. 5.
    Wilson HT. Rubber dermatitis: an investigation of 106 cases of contact dermatitis caused by rubber. Br J Dermatol. 1969;81(3):175–9.PubMedCrossRefGoogle Scholar
  6. 6.
    Fisher AA. Condom conundrums: Part I. Cutis. 1991;48(5):359–60.PubMedGoogle Scholar
  7. 7.
    Fisher AA. Condom dermatitis in either partner. Cutis. 1987;39(4):281, 284–5.Google Scholar
  8. 8.
    Nethercott JR, Lawrence MJ. Allergic contact dermatitis due to nonylphenol ehtoxylate (nonoxynol-6). Contact Dermatitis. 1984;10(4):235–9.PubMedCrossRefGoogle Scholar
  9. 9.
    Fisher AA. Reactions of the mucous membrane to contactants. Clin Dermatol. 1987;5(2):123–36.PubMedCrossRefGoogle Scholar
  10. 10.
    Goldman BD. Common dermatoses of the male genitalia: recognition of differences in genital rashes and lesions is essential and attainable. Postgrad Med. 2000;108(4):89–91, 95–6.CrossRefGoogle Scholar
  11. 11.
    Birley HD, Walker MM, Luzzi GA, et al. Clinical features and management of recurrent balanitis; association with atopy and genital washing. Genitourin Med. 1993;69(5):400–3.PubMedGoogle Scholar
  12. 12.
    Warner E, Strashin E. Benefits and risks of circumcision. Can Med Assoc J. 1981;125(9):967–76, 992.PubMedGoogle Scholar
  13. 13.
    Schlosser BJ. Contact dermatitis of the vulva. Dermatol Clin. 2010;28:697–706.PubMedGoogle Scholar
  14. 14.
    Weichert GE. Approach to the treatment of anogenital pruritus. Dermatol Ther. 2004;17:129–33.PubMedCrossRefGoogle Scholar
  15. 15.
    Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17:8–19.PubMedCrossRefGoogle Scholar
  16. 16.
    Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. Dermatol Ther. 2004;17(1):8–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Stewart KMA. Clinical care of vulvar pruritus, with emphasis on one common cause, lichen simplex chronicus. Dermatol Clin. 2010;28:669–80.PubMedGoogle Scholar
  18. 18.
    Young Jr AW. Cutaneous inflammations of the male genitalia. Mod Treat. 1970;7(5):973–98.PubMedGoogle Scholar
  19. 19.
    Kelekci HK, Uncu HG, Yilmaz B, Ozdemir O, Sut D, Kelekci S. Pimecrolimus 1% cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: a prospective non-controlled case series. J Dermatolog Treat. 2008;19:274–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Meeuwis KAP, de Hullu JA, de Jager MEA, Massuger LFAG, van de Kerkhof PCM, van Rossum MM. Genital psoriasis: a questionnaire-based survey on a concealed skin disease in the Netherlands. J Eur Acad Dermatol Venereol. 2010;24:1425–30.PubMedCrossRefGoogle Scholar
  21. 21.
    Kohn FM, Pflieger-Bruss S, Schill WB. Penile skin diseases. Andrologia. 1993;31 Suppl 1:3–11.Google Scholar
  22. 22.
    Meeuwis KAP, de Hullu JA, van de Nieuwenhof HP, Evers AWM, Massuger LFAG, van de Kerkhof PCM, van Rossum MM. Quality of life and sexual health in patients with genital psoriasis. Br J Dermatol. 2011;164:1247–55.PubMedCrossRefGoogle Scholar
  23. 23.
    Meeuwis KAP, de Hullu JA, Massuger LFAG, van de Kerkhof PCM, van Rossum MM. Genital psoriasis: a systematic literature review on this hidden skin disease. Acta Derm Venereol. 2011;91:5–11.PubMedGoogle Scholar
  24. 24.
    Boyd AS, Neldner KH. Lichen planus. J Am Acad Dermatol. 1991;25(4):593–619.PubMedCrossRefGoogle Scholar
  25. 25.
    Fox BJ, Odom RB. Papulosquamous diseases: a review. J Am Acad Dermatol. 1985;12(4):597–624.PubMedCrossRefGoogle Scholar
  26. 26.
    Schmidt H. Frequency duration and localization of lichen planus. A study based on 181 patients. Acta Derm Venereol. 1961;41:164–7.PubMedGoogle Scholar
  27. 27.
    Belfiore P, Di Fede O, Cabibi D, Campisi G, Amaru GS, De Cantisa S, Maresi E. Prevalence of vulval lichen planus in a cohort of women with oral lichen planus: an interdisciplinary study. Br J Dermatol. 2006;155:994–8.PubMedCrossRefGoogle Scholar
  28. 28.
    Helgesen ALO, Gjersvik P, Jebsen P, Kirschner R, Tanbo T. Vaginal involvement in genital erosive lichen planus. Acta Obstet Gynecol Scand. 2010;89:966–70.PubMedCrossRefGoogle Scholar
  29. 29.
    Santegoets LAM, Helmerhorst T, van der Meijden WI. A retrospective study of 95 women with a clinical diagnosis of genital lichen planus. J Low Genit Tract Dis. 2010;14(4):323–8.PubMedCrossRefGoogle Scholar
  30. 30.
    Moyal-Barracco M, Edwards L. Diagnosis and therapy of anogenital lichen planus. Dermatol Ther. 2004;17(1):38–46.PubMedCrossRefGoogle Scholar
  31. 31.
    Cox NH. Squamous cell carcinoma arising in lichen planus of the penis during topical cyclosporin therapy. Clin Exp Dermatol. 1996;21(4):323–4.PubMedCrossRefGoogle Scholar
  32. 32.
    Mirowski GW, Goddard A. Treatment of vulvovaginal lichen planus. Dermatol Clin. 2010;28:717–25.PubMedCrossRefGoogle Scholar
  33. 33.
    Lundqvist EN, Wahlin YB, Bergdahl M, Bergdahl J. Psychological health in patients with genital and oral erosive lichen planus. J Eur Acad Dermatol Venereol. 2006;20:661–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Lonsdale-Eccles AA, Velangi S. Topical pimecrolimus in the treatment of genital lichen planus: a prospective case series. Br J Dermatol. 2005;153:390–4.PubMedCrossRefGoogle Scholar
  35. 35.
    Laxmisha C, Thappa DM. Generalized lichen nitidus with down syndrome. J Eur Acad Dermatol Venereol. 2006;20:1156–7.PubMedCrossRefGoogle Scholar
  36. 36.
    Kim YC, Shim SD. Two cases of generalized lichen nitidus treated successfully with narrow-band UV-B phototherapy. Int J Dermatol. 2006;45:615–7.PubMedCrossRefGoogle Scholar
  37. 37.
    Murphy R. Lichen sclerosus. Dermatol Clin. 2010;28:707–15.PubMedCrossRefGoogle Scholar
  38. 38.
    Singh N, Thappa DM, Jaisankar TJ, Habeebullah S. Pattern of non-venereal dermatoses of female external genitalia in South India. Dermatol Online J. 2008;14(1):1.PubMedGoogle Scholar
  39. 39.
    McPherson T, Cooper S. Vulval lichen sclerosus and lichen planus. Dermatol Ther. 2010;23:523–32.PubMedCrossRefGoogle Scholar
  40. 40.
    Neill SM, Lewis FM, Tatnall FM, Cox NH. British association of dermatologists’ guidelines for the management of lichen sclerosus 2010. Br J Dermatol. 2010;163:672–82.PubMedCrossRefGoogle Scholar
  41. 41.
    Pipkin C. Erosive diseases of the vulva. Dermatol Clin. 2010;28:737–51.PubMedCrossRefGoogle Scholar
  42. 42.
    Das S, Tunuguntla HS. Balanitis xerotica obliterans—a review. World J Urol. 2000;18(6):382–7.PubMedCrossRefGoogle Scholar
  43. 43.
    Aynaud O, Plantier F. Genital lichen sclerosus treated by carbon dioxide laser. Eur J Dermatol. 2010;20(3):387–8.PubMedGoogle Scholar
  44. 44.
    Hrebinko RL. Circumferential laser vaporization for severe meatal stenosis secondary to balanitis xerotica obliterans. J Urol. 1996;156(5):1735–6.PubMedCrossRefGoogle Scholar
  45. 45.
    Kartamaa M, Reitamo S. Treatment of lichen sclerosus with carbon dioxide laser vaporization. Br J Dermatol. 1997;136(3):356–9.PubMedCrossRefGoogle Scholar
  46. 46.
    Windahl T, Hellsten S. Carbon dioxide laser treatment of lichen sclerosus et atrophicus. J Urol. 1993;150(3):868–70.PubMedGoogle Scholar
  47. 47.
    Neuhaus IM, Skidmore RA. Balanitis xerotica obliterans and its differential diagnosis. J Am Board Fam Pract. 1999;12(6):473–6.PubMedGoogle Scholar
  48. 48.
    Albers SE, Taylor G, Huyer D, Oliver G, Krafchik BR. Vulvitis circumscripta plasmacellularis mimicking child abuse. J Am Acad Dermatol. 2000;42(6):1078–80.PubMedCrossRefGoogle Scholar
  49. 49.
    Virgili A, Mantovani L, Lauriola MM, Marzola A, Corazza M. Tacrolimus 0.1% ointment: is it really effective in plasma cell vulvitis? Report of four cases. Dermatology. 2008;216:243–6.PubMedCrossRefGoogle Scholar
  50. 50.
    Kavanagh GM, Burton PA, Kennedy CTC. Vulvitis chronica plasmacellularis (Zoon’s vulvitis). Br J Dermatol. 1993;129:92–3.PubMedCrossRefGoogle Scholar
  51. 51.
    Pastar Z, Rados J, Lipozencic J, Skerlev M, Loncaric D. Zoon plasma cell balanitis: an overview and role of histopathology. Acta Dermatovenerol Croat. 2004;12(4):268–73.PubMedGoogle Scholar
  52. 52.
    Retamar RA, Kien MC, Chouela EN. Zoon’s balanitis: presentation of 15 patients, five treated with a carbon dioxide laser. Int J Dermatol. 2003;42(4):305–7.PubMedCrossRefGoogle Scholar
  53. 53.
    Fernandez-Acenero MJ, Cordova S. Zoon’s vulvitis (vulvitis circumscripta plasmacellularis). Arch Gynecol Obstet. 2010;282:351–2.PubMedCrossRefGoogle Scholar
  54. 54.
    Fischer G. Vulvar fixed drug eruption. A report of 13 cases. J Reprod Med. 2007;52(2):81–6.PubMedGoogle Scholar
  55. 55.
    Zawar V, Kirloskar M, Chuh A. Fixed drug eruption—a sexually inducible reaction? Int J STD AIDS. 2004;15:560–3.PubMedCrossRefGoogle Scholar
  56. 56.
    Lee AY. Fixed drug eruptions: incidence, recognition, and avoidance. Am J Clin Dermatol. 2000;1(5):277–85.PubMedCrossRefGoogle Scholar
  57. 57.
    Nigen S, Knowles SR, Shear NH. Drug eruptions: approaching the diagnosis of drug-induced skin diseases. J Drugs Dermatol. 2003;2(3):278–99.PubMedGoogle Scholar
  58. 58.
    Ozkaya-Bayazit E. Specific site involvement in fixed drug eruption. J Am Acad Dermatol. 2003;49:1003–7.PubMedCrossRefGoogle Scholar
  59. 59.
    Rodin P, Kolator B. Carriage of yeasts on the penis. Br Med J. 1976;1(6018):1123–4.PubMedCrossRefGoogle Scholar
  60. 60.
    Lisboa C, Costa AR, Ricardo E, Santos A, Azevedo F, Pina-Vaz C, Rodrigues AG. Genital candidosis in heterosexual couples. J Eur Acad Dermatol Venereol. 2011;25:145–51.PubMedCrossRefGoogle Scholar
  61. 61.
    Abdullah AN, Drake SM, Wade AA, Walzman M. Balanitis (balanoposthitis) in patients attending a department of genitourinary medicine. Int J STD AIDS. 1992;3(2):128–9.PubMedGoogle Scholar
  62. 62.
    Dockerty WG, Sonnex C. Candidal balano-posthitis: a study of diagnostic methods. Genitourin Med. 1995;71(6):407–9.PubMedGoogle Scholar
  63. 63.
    Harriott MM, Lilly EA, Rodriguez TE, Fidel Jr PL, Noverr MC. Candida albicans forms biofilms on the vaginal mucosa. Microbiology. 2010;156:3635–44.PubMedCrossRefGoogle Scholar
  64. 64.
    Janniger CK, Schwartz RA, Szepietowski JC, Reich A. Intertrigo and common secondary skin infections. Am Fam Physician. 2005;72(5):833–8.PubMedGoogle Scholar
  65. 65.
    Mayser P. Mycotic infections of the penis. Andrologia. 1993;31 Suppl 1:13–6.Google Scholar
  66. 66.
    Stary A, Soeltz-Szoets J, Ziegler C, Kinghorn GR, Roy RB. Comparison of the efficacy and safety of oral fluconazole and topical clotrimazole in patients with candida balanitis. Genitourin Med. 1996;72(2):98–102.PubMedGoogle Scholar
  67. 67.
    Guitart J, Woodley DT. Intertrigo: a practical approach. Compr Ther. 1994;20(7):402–9.PubMedGoogle Scholar
  68. 68.
    Hay RJ. The management of superficial candidiasis. J Am Acad Dermatol. 1999;40(6 Pt 2):S35–42.PubMedCrossRefGoogle Scholar
  69. 69.
    Gupta AK, Chaudhry M, Elewski B. Tinea corporis, tinea cruris, tinea nigra, and piedra. Dermatol Clin. 2003;21(3):395–400, v.PubMedCrossRefGoogle Scholar
  70. 70.
    Gupta AK, Einarson TR, Summerbell RC, Shear NH. An overview of topical antifungal therapy in dermatomycoses. A North American perspective. Drugs. 1998;55(5):645–74.PubMedCrossRefGoogle Scholar
  71. 71.
    Lesher Jr JL. Oral therapy of common superficial fungal infections of the skin. J Am Acad Dermatol. 1999;40(6 Pt 2):S31–4.PubMedCrossRefGoogle Scholar
  72. 72.
    Holdiness MR. Management of cutaneous erythrasma. Drugs. 2002;62(8):1131–41.PubMedCrossRefGoogle Scholar
  73. 73.
    Danby FW, Margesson LJ. Hidradenitis suppurativa. Dermatol Clin. 2010;28:779–93.PubMedCrossRefGoogle Scholar
  74. 74.
    Buyukasik O, Hasdemir AO, Kahramansoy N, Col C, Erkol H. Surgical approach to extensive hidradenitis suppurativa. Dermatol Surg. 2011;37:835–42.PubMedCrossRefGoogle Scholar
  75. 75.
    Esmann S, Jemec GB. Psychosocial impact of hidradenitis suppurativa: a qualitative study. Acta Derm Venereol. 2011;91:328–32.PubMedCrossRefGoogle Scholar
  76. 76.
    Yazdanyar S, Jemec GB. Hidradenitis suppurativa: a review of cause and treatment. Curr Opin Infect Dis. 2011;24(2):118–23.PubMedCrossRefGoogle Scholar
  77. 77.
    Gulliver WP, Jemec GB, Baker KA. Experience with ustekinumab for the treatment of moderate to severe hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2012;26(7):911–4.PubMedCrossRefGoogle Scholar
  78. 78.
    Miller I, Lynggaard CD, Lophaven S, Zachariae C, Dufour DN, Jemec GB. A double-blind placebo-controlled randomized trial of adalimumab in the treatment of hidradenitis suppurativa. Br J Dermatol. 2011;165(2):391–8.PubMedCrossRefGoogle Scholar
  79. 79.
    Schlapbach C, Hanni T, Yawalkar N, Hunger RE. Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa. J Am Acad Dermatol. 2011;65(40):790–8.PubMedCrossRefGoogle Scholar
  80. 80.
    Delage M, Samimi M, Atlan M, Machet L, Lorette G, Maruani A. Efficacy of infliximab for hidradenitits suppurativa: assessment of clinical and biological inflammatory markers. Acta Derm Venereol. 2011;91:169–71.PubMedGoogle Scholar
  81. 81.
    Marzano DA, Haefner HK. The bartholin gland cyst: past, present and future. J Low Genit Tract Dis. 2004;8(3):195–204.PubMedCrossRefGoogle Scholar
  82. 82.
    Wechter ME, Wu JM, Marzano D, Haefner H. Management of Bartholin Duch cysts and abscesses: a systematic review. Obstet Gynecol Surv. 2009;64(6):395–404.PubMedCrossRefGoogle Scholar
  83. 83.
    Agarwal SK, Bhattacharya SN, Singh N. Pearly penile papules: a review. Int J Dermatol. 2004;43(3):199–201.CrossRefGoogle Scholar
  84. 84.
    Taniguchi S, Inoue A, Hamada T. Angiokeratoma of Fordyce: a cause of scrotal bleeding. Br J Urol. 1994;73(5):589–90.PubMedCrossRefGoogle Scholar
  85. 85.
    Ozdemir M, Baysal I, Engin B, Ozdemir S. Treatment of angiokeratoma of Fordyce with long-pulse neodymium-doped yttrium aluminium garnet laser. Dermatol Surg. 2009;35:92–7.PubMedCrossRefGoogle Scholar
  86. 86.
    Yahya H, Rafindadi AH. Idiopathic scrotal calcinosis: a report of four cases and review of the literature. Int J Dermatol. 2005;44(3):206–9.PubMedCrossRefGoogle Scholar
  87. 87.
    Pak K, Takayama H, Tomoyoshi T. Idiopathic calcinosis of scrotum. Urology. 1983;21(5):521–3.PubMedCrossRefGoogle Scholar
  88. 88.
    Graham JH, Helwig EG. Erythroplasia of queyrat. A clinicopathologic and histochemical study. Cancer. 1973;32(6):1396–414.PubMedCrossRefGoogle Scholar
  89. 89.
    Lai KW, Mercurio MG. Medical and surgical approaches to vulvar intraepithelial neoplasia. Dermatol Ther. 2010;23:477–84.PubMedCrossRefGoogle Scholar
  90. 90.
    Saraiya M, Watson M, Wu X, King JB, Chen VW, Smith JS, Giuliano AR. Incidence of in situ and invasive vulvar cancer in the US, 1998–2003. Cancer. 2008;113 Suppl 10:2865–72.PubMedCrossRefGoogle Scholar
  91. 91.
    Cupp MR, Malek RS, Goellner JR, Smith TF, Espy MJ. The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J Urol. 1995;154(3):1024–9.PubMedCrossRefGoogle Scholar
  92. 92.
    Sarkar FH, Miles BJ, Plieth DH, Crissman JD. Detection of human papillomavirus in squamous neoplasm of the penis. J Urol. 1992;147(2):389–92.PubMedGoogle Scholar
  93. 93.
    Campus GV, Alia F, Bosincu L. Squamous cell carcinoma and lichen sclerosus et atrophicus of the prepuce. Plast Reconstr Surg. 1992;89(5):962–4.PubMedCrossRefGoogle Scholar
  94. 94.
    Johnson DE, Fuerst DE, Ayala AG. Carcinoma of the penis. Experience with 153 cases. Urology. 1973;1(5):404–8.PubMedCrossRefGoogle Scholar
  95. 95.
    Madsen BS, Jensen HL, van den Brule AJC, Wohlfahrt J, Frisch M. Risk factors for invasive squamous cell carcinoma of the vulva and vagina—population-based case–control study in Denmark. Int J Cancer. 2008;122:2827–34.PubMedCrossRefGoogle Scholar
  96. 96.
    Burgers JK, Badalament RA, Drago JR. Penile cancer: clinical presentation, diagnosis, and staging. Urol Clin North Am. 1992;19(2):247–56.PubMedGoogle Scholar
  97. 97.
    Narayana AS, Olney LE, Loening SA, Weimar GW, Culp DA. Carcinoma of the penis: analysis of 219 cases. Cancer. 1982;49(10):2185–91.PubMedCrossRefGoogle Scholar
  98. 98.
    de Bie RP, van de Nieuwenhof HP, Bekkers RLM, et al. Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities. Br J Cancer. 2009;101:27–31.PubMedCrossRefGoogle Scholar
  99. 99.
    Schellhammer PF, Jordan GH, Robey EL, Spaulding JT. Premalignant lesions and nonsquamous malignancy of the penis and carcinoma of the scrotum. Urol Clin North Am. 1992;19(1):131–42.PubMedGoogle Scholar
  100. 100.
    Lowe FC. Squamous cell carcinoma of the scrotum. J Urol. 1983;130(3):423–7.PubMedGoogle Scholar
  101. 101.
    Mehta NJ, Torno R, Sorra T. Extramammary paget’s disease. South Med J. 2000;93(7):713–5.PubMedGoogle Scholar
  102. 102.
    Lam C, Funaro D. Extramammary Paget’s disease: summary of current knowledge. Dermatol Clin. 2010;28:807–26.PubMedCrossRefGoogle Scholar
  103. 103.
    Lee SJ, Choel YS, Jung HD, et al. A multicenter study on extramammary Paget’s disease in Korea. Int J Dermatol. 2011;50:508–15.PubMedCrossRefGoogle Scholar
  104. 104.
    Smith DJ, Handy FC, Evans JW, Falzon M, Chapple CR. Paget’s disease of the glans penis: an unusual urological malignancy. Eur Urol. 1994;25(4):316–9.PubMedGoogle Scholar
  105. 105.
    Love EW, Schmitt AR, Bordeaux JS. Management of unusual cutaneous malignancies: atypical malignant fibroxanthoma, fibrous histiocytoma, sebaceous extramammary carcinoma, Paget disease. Dermatol Clin. 2011;29:201–16.PubMedCrossRefGoogle Scholar
  106. 106.
    Hegarty PK, Suh J, Fisher MB, et al. Penoscrotal extramammary Paget’s disease: The University of Texas M. D. Anderson Cancer Center Contemporary Experience. J Urol. 2011;186:97–102.PubMedCrossRefGoogle Scholar
  107. 107.
    Li B, Ding Q. Extramammary Paget’s disease involving the penis, scrotum and the axilla. Australas J Dermatol. 2011;52:e18–20.PubMedCrossRefGoogle Scholar
  108. 108.
    Kitagawa KH, Bogner P, Zeitouni NC. Photodynamic therapy with methyl-aminolevulinate for the treatment of double extramammary Paget’s disease. Dermatol Surg. 2011;37:1043–6.PubMedCrossRefGoogle Scholar
  109. 109.
    Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol. 2008;9:973–81.PubMedCrossRefGoogle Scholar
  110. 110.
    Rashid AM, Williams RM, Horton LW. Malignant melanoma of penis and male urethra: is it a difficult tumor to diagnose? Urology. 1993;41(5):470–1.PubMedCrossRefGoogle Scholar
  111. 111.
    Zurrida S, Bartoli C, Clemente C, De Palo G. Malignant melanoma of the penis. A report of four cases. Tumori. 1990;76(6):599–602.PubMedGoogle Scholar
  112. 112.
    Manivel JC, Fraley EE. Malignant melanoma of the penis and male urethra: 4 case reports and literature review. J Urol. 1988;139(4):813–6.PubMedGoogle Scholar
  113. 113.
    An J, Li B, Wu L, Lu H, Li N. Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res. 2009;19(4):267–70.PubMedCrossRefGoogle Scholar
  114. 114.
    Johnson DE, Ayala AG. Primary melanoma of penis. Urology. 1973;2(2):174–7.PubMedCrossRefGoogle Scholar
  115. 115.
    Breslow A. Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma. Ann Surg. 1975;182(5):572–5.PubMedCrossRefGoogle Scholar
  116. 116.
    Ho GY, Bierman R, Beardsley L, et al. Natural history of cervicovaginal papillomavirus infection in young women. N Eng J Med. 1998;338(7):423–8.CrossRefGoogle Scholar
  117. 117.
    Koutsky LA, Galloway DA, Holmes KK. Epidemiology of genital human papillomavirus infection. Epidemiol Rev. 1998;10:122–63.Google Scholar
  118. 118.
    Insigna RP, Dasbach EJ, Myers ER. The health and economic burden of genital warts in a set of private health plans in the United States. Clin Infect Dis. 2003;36(11):1397–403.CrossRefGoogle Scholar
  119. 119.
    U.S. Food and Drug Administration. Label for Cervarix. Accessed 1 Aug 2011
  120. 120.
    U.S. Food and Drug Administration. Label for Gardasil. Accessed 1 Aug 2011
  121. 121.
    Bauer GR, Khobzi N, Coleman TA. Herpes simplex virus type 2 seropositivity and relationship status among U.S. adults age 20 to 49: a population-based analysis. BMC Infect Dis. 2010;10:359.PubMedCrossRefGoogle Scholar
  122. 122.
    Horowitz R, Aierstuck S, Williams EA, Melby B. Herpes simplex virus infection in a university health population: clinical manifesations, epidemiology, and implications. J Am Coll Health. 2010;59(2):69–74.CrossRefGoogle Scholar
  123. 123.
    Nath AK, Thappa DM. Newer trends in the management of genital herpes. Indian J Dermatol Venereol Leprol. 2009;75(6):566–74.PubMedCrossRefGoogle Scholar
  124. 124.
    Morello CS, Levinson MS, Kraynyak KA, Spector DH. Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease. J Virol. 2011;85(7):3461–72.PubMedCrossRefGoogle Scholar
  125. 125.
    Zeltser R, Kurban AK. Syphilis. Clin Dermatol. 2004;22(6):461–8.PubMedCrossRefGoogle Scholar
  126. 126.
    Frippiat F, Moutschen M. Syphilis treatment in the human immunodeficiency virus-infected patient: follow the guidelines. Clin Infect Dis. 2011;53(8):845.PubMedCrossRefGoogle Scholar
  127. 127.
    Psomas KC, Brun M, Causse A, Atoui N, Reynes J, Le Moing V. Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis. Med Mal Infect. 2012;42(1):15–9.PubMedCrossRefGoogle Scholar
  128. 128.
    Mellick LB. Wire cutters and penis skin entrapped by zipper sliders. Pediatr Emerg Care. 2011;27(5):451–2.PubMedCrossRefGoogle Scholar
  129. 129.
    Badawy H, Soliman A, Ouf A, Hammad A, Orabi S, Hanno A. Progressive hair coil penile tourniquet syndrome: multicenter experience with 25 cases. J Pediatr Surg. 2010;45:1514–8.PubMedCrossRefGoogle Scholar
  130. 130.
    Singh I, Joshi MK, Jaura MS. Strangulation of penis by a ball bearing device. J Sex Med. 2010;7:3793–7.PubMedCrossRefGoogle Scholar
  131. 131.
    Jiatao J, Bin X, Haumao Y, Jianguo H, Bing L, Yinghao S. Removal of a long PVC pipe strangulated in the penis by hot-melt method. J Sex Med. 2011;8:627–30.PubMedCrossRefGoogle Scholar
  132. 132.
    Abdulcadir J, Margairaz C, Boulvain M, Irion O. Care of women with female genital mutilation/cutting. Swiss Med Wkly. 2010;140:w13137.Google Scholar
  133. 133.
    Dave AJ, Sethi A, Morrone A. Female genital mutilation: what every American dermatologist needs to know. Dermatol Clin. 2011;29:103–9.PubMedGoogle Scholar
  134. 134.
    Rasheed SM, Ebd-Ellah AH, Yousef FM. Female genital mutilation in Upper Egypt in the new millennium. Int J Gynaecol Obstet. 2011;114:47–50.PubMedCrossRefGoogle Scholar
  135. 135.
    Karmaker B, Kandala NB, Chung D, Clarke A. Factors associated with female genital mutilation in Burkina Faso and its policy implications. Int J Equity Health. 2011;10:20.PubMedCrossRefGoogle Scholar
  136. 136.
    Cui W. International agency calls for end to “inhuman practice” of female genital mutilation. Br Med J. 2011;342:d890.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of DermatologyCleveland ClinicClevelandUSA

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