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Dietary Mg Intake and Biomarkers of Inflammation and Endothelial Dysfunction

  • Simin Liu
  • Sara A. Chacko
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

Magnesium (Mg) is an essential mineral found abundantly in whole grains, leafy green vegetables, legumes, and nuts that plays a central role in hundreds of physiological processes in the human body. According to national survey data from National Health and Nutrition Examination Survey (NHANES) 1999–2000, a large proportion of the US population consumes inadequate dietary Mg [1]. Given the fundamental role of Mg in diverse cellular reactions, this is not without consequence. Low dietary Mg intake has been linked to a range of adverse health outcomes including those related to metabolic and inflammatory processes such as hypertension [2, 3], type 2 diabetes (T2D) [4], and metabolic syndrome [2] in both experimental and observational settings. The pathophysiologic mechanisms underlying these relations are not well understood; however, a maturing body of evidence suggests that suboptimal dietary Mg intake status may affect metabolism and inflammation pathways ultimately leading to the clinical manifestation of T2D, metabolic syndrome, and CVD.

Keywords

Dietary magnesium Inflammation C-reactive protein Endothelial dysfunction Diabetes 

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.UCLA Departments of Epidemiology, Medicine, and Obstetrics & GynecologyCenter for Metabolic Disease PreventionLos AngelesUSA
  2. 2.UCLA Department of EpidemiologyCenter for Metabolic Disease PreventionLos AngelesUSA

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