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Magnesium in Human Health and Disease pp 255–267Cite as

Magnesium and Traumatic Brain Injury

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Part of the book series: Nutrition and Health ((NH))

Abstract

Magnesium is one of the most important ions in the body and is present in high concentrations within all cells. It is indispensable in terms of maintenance and regulation of general cellular metabolism and function due to the central roles it plays in nearly every aspect of cell function, including energy metabolism and maintenance of ionic gradients. Given that magnesium is so essential for normal cellular function, disruption of magnesium homeostasis has deleterious consequences. Indeed, the detrimental effects of the disruption of magnesium homeostasis are clearly observed following trauma to the CNS, leading to serious biochemical changes. Accordingly, the aim of this chapter is to review both the role of magnesium in secondary injury following traumatic brain injury (TBI) and also the efficacy of the experimental and clinical administration of magnesium as a novel therapeutic for the treatment of TBI.

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  1. Adelaide Centre for Neuroscience Research, School of Medical Sciences, University of Adelaide, North Terrace, Adelaide, SA, 5005, Australia

    Renée J. Turner Ph.D. & Robert Vink

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  1. Renée J. Turner Ph.D.
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Correspondence to Renée J. Turner Ph.D. .

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  1. Arizona Health Science Center, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Turner, R.J., Vink, R. (2013). Magnesium and Traumatic Brain Injury. In: Watson, R., Preedy, V., Zibadi, S. (eds) Magnesium in Human Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-044-1_18

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