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Endometriosis and Oxidative Stress

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Studies on Women's Health

Abstract

Endometriosis is a chronic gynecologic disease process with multifactorial etiology. Increased oxidative stress, a result of increased production of free radicals or depletion of the body’s endogenous antioxidant defense, has been implicated in its pathogenesis. Oxidative stress is thought to promote angiogenesis and the growth and proliferation of endometriotic implants. Oxidative stress in the reproductive tract microenvironment is known to negatively affect sperm count and quality and may also arrest fertilized egg division leading to embryo death. Increased DNA damage in sperm, oocytes, and resultant embryos may account for the increase in miscarriages and fertilization and implantation failures seen in patients with endometriosis. The evidence linking endometriosis and infertility to endogenous pro-oxidant imbalance provides a rationale for the empiric use of antioxidant therapy. Vitamin C and E deficiency has been demonstrated in women with endometriosis. Observational and randomized controlled studies have shown vitamin C and E combination therapy to decrease markers of oxidative stress.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Mount Sinai School of Medicine, 1176 5th Ave Klingenstein Pavilion, 9th Floor, New York, NY, 10029, USA

    Lucky H. Sekhon

  2. Center for Reproductive Medicine, Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Ashok Agarwal

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Correspondence to Ashok Agarwal .

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Editors and Affiliations

  1. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

  2. Gynaecology and Reproductive Medicine, Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, United Kingdom

    Nabil Aziz

  3. College of Medicine, OB/Gyn Department, University of South Alabama, Cox Street, Suite A 251, Mobile, 36604, Alabama, USA

    Botros Rizk

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Sekhon, L.H., Agarwal, A. (2013). Endometriosis and Oxidative Stress. In: Agarwal, A., Aziz, N., Rizk, B. (eds) Studies on Women's Health. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-041-0_9

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