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Many Pathways to Destruction: The Role of the Centrosome in, and Its Control by Regulated Proteolysis

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The Centrosome

Abstract

Centrosome duplication must be precisely regulated to ensure the production of a bipolar mitotic spindle. As with other cell cycle events, irreversible protein destruction is critical for the fidelity of centrosome duplication, and the failure to properly destroy any of several critical centrosome regulators leads to the production of excess centrosomes that interfere with bipolar spindle assembly. Many pathways that regulate the degradation of these critical regulators are found at centrosomes, and in some cases the destruction occurs at the centrosome. This chapter discusses the various degradation machineries found at centrosomes, and some of the many aspects of centrosome biology that are controlled by protein degradation.

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  1. Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH, 43210, USA

    Harold A. Fisk

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  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia, East Rollins Street 1600, Columbia, 65211, Missouri, USA

    Heide Schatten

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Fisk, H.A. (2012). Many Pathways to Destruction: The Role of the Centrosome in, and Its Control by Regulated Proteolysis. In: Schatten, H. (eds) The Centrosome. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-035-9_8

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