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Centrosome Regulation and Breast Cancer

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The Centrosome

Abstract

Chromosomal instability and aneuploidy are commonly observed in breast tumor cells. Loss of function of the breast- and ovarian-specific tumor suppressor gene, BRCA1, results in supernumerary centrosomes that are likely to contribute to the genetic instability and tumorigenesis in breast cancer cells. Other DNA repair proteins also contribute to the regulation of the centrosome along with several oncogenic and tumor suppressor proteins. A number of centrosome regulators that are known to be involved in breast cancer will be discussed with a focused discussion of BRCA1 and its ubiquitin ligase activity in the regulation of centrosome number.

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Further readings

  • Note: Two papers relevant to this chapter have been recently published and are placed further readings

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  • Kais Z, Barsky SH, Mathsyaraja H, Zha A, Ransburgh DJ, He G, Pilarski RT, Shapiro CL, Huang K, Parvin JD. (2011) KIAA0101 Interacts with BRCA1 and regulates centrosome number. Mol Cancer Res 9(8):1091–1099

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  • Kais Z, Chiba N, Ishioka C, Parvin JD. (2011) Functional differences among BRCA1 missense mutations in the control of centrosome duplication. Oncogene 31(6):799–804

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Acknowledgments

This work was supported by funding from the NIH/NCI (R01 CA141090 and R01 CA111480) to J.D.P.

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Authors and Affiliations

  1. Department of Biomedical Informatics, Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA

    Zeina Kais & Jeffrey D. Parvin

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  1. Zeina Kais
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  2. Jeffrey D. Parvin
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Correspondence to Jeffrey D. Parvin .

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  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia, East Rollins Street 1600, Columbia, 65211, Missouri, USA

    Heide Schatten

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Kais, Z., Parvin, J.D. (2012). Centrosome Regulation and Breast Cancer. In: Schatten, H. (eds) The Centrosome. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-035-9_14

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