Abstract
Toxicology is the branch of medicine that deals with the study of the adverse effects of chemicals and biological agents on the human body. It is the study of symptoms, mechanisms, treatments, and detection of poisoning. The broad scope of toxicology covers not only the adverse effects of therapeutics but also environmental agents and poisons. Nanotoxicology covers safety issues relevant to nanomaterials.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Bhabra G, Sood A, Fisher B, et al. Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotech 2009;4:876–83.
Braydich-Stolle L, Hussain S, Schlager J, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germ-line stem cells. Toxicol Sci 2005;88:412–9.
Choi HS, Ashitate Y, Lee JH, et al. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 2010b;28:1300–3.
Chu M, Wu Q, Yang H, et al. Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small 2010;6:670–8.
Currall SC, King EB, Lane N, et al. What drives public acceptance of nanotechnology? Nat Nanotech 2006;1:153–5.
De Jong WH, Hagens WI, Krystek P, et al. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008;29:1912–19.
Derfus AM, Chan CW, Bhatia SN, et al. Probing the Cytotoxicity of Semiconductor Quantum Dots Nano Letters 2004;4:11–18.
Ge C, Du J, Zhao L, et al. Binding of blood proteins to carbon nanotubes reduces cytotoxicity. Proc Natl Acad Sci U S A 2011;108:16968–73.
Goodman CM, McCusker CD, Yilmaz T, Rotello VM. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 2004;15:897–900.
Kagan VE, Konduru NV, Feng W, et al. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol 2010;5:354–9.
Kattumuri V, Katti K, Bhaskaran S, et al. Gum Arabic as a Phytochemical Construct for the Stabilization of Gold Nanoparticles: In Vivo Pharmacokinetics and X-ray-Contrast-Imaging Studies. Small 2007;3:333–41.
Koziara JM, Oh JJ, Akers WS, Ferraris SP, Mumper RJ. Blood compatibility of cetyl alcohol/polysorbate-based nanoparticles. Pharm Res 2005;22:1821–8.
Li C, Liu H, Sun Y, et al. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. J Mol Cell Biol 2009;1:37–45.
Magrez A, Kasas S, Salicio V, et al. Cellular Toxicity of Carbon-Based Nanomaterials. Nano Lett 2006;6:1121–5.
Mecke A, Uppuluri S, Sassanella TM, et al. Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers. Chem Phys Lipids 2004;132:3–14.
Mills NL, Amin N, Robinson SD, et al. Do Inhaled Carbon Nanoparticles Translocate Directly Into the Circulation in Man? Am J Respir Crit Care Med 2006;173:426–31.
Monteiro-Riviere NA, Nemanich RJ, Inman AO, et al. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicol Lett 2005;155:377–84.
Mortensen LJ, Oberdörster G, Pentland AP, Delouise LA. In Vivo Skin Penetration of Quantum Dot Nanoparticles in the Murine Model: The Effect of UVR. Nano Lett 2008;8:2779–87.
Oberdorster E. Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 2004;112:1058–62.
Oberdorster G, Maynard A, Castranova V, et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology 2005;2:8
Park MV, Lankveld DP, van Loveren H, de Jong WH. The status of in vitro toxicity studies in the risk assessment of nanomaterials. Nanomed 2009;4:669–85.
Peters A, Veronesi B, Calderon-Garciduenas L, et al. Translocation and potential neurological effects of fine and ultrafine particles: A critical update. Particle and Fibre Toxicology 2006;3:13.
Powell MC, Kanarek MS. Nanomaterial health effects-Part 2: Uncertainties and recommendations for the future. WMJ 2006;105:18–23.
Radomski A, Jurasz P, Alonso-Escolano D, et al. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 2005;146:882–93.
Renwick LC, Brown D, Clouter A, Donaldson K. Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 2004;61:442–7.
Sayes C, et al. The differential cytotoxicity of water-soluble fullerenes. Nano Lett 2004;4:881–7.
Sayes CM, Gobin AM, Ausman KD, et al. Nano-C(60) cytotoxicity is due to lipid peroxidation. Biomaterials 2005;26:7587–95.
Sayes CM, Liang F, Hudson JL, et al. Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 2006;161:135–42.
Singh R, Pantarotto D, Lacerda L, et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A 2006;103:3357–62.
Stampfl A, Maier M, Radykewicz R, et al. Langendorff heart: a model system to study cardiovascular effects of engineered nanoparticles. ACS Nano 2011;5:5345–53.
Thomas K, Aguar P, Kawasaki H, et al. Research Strategies for Safety Evaluation of Nanomaterials, Part VIII: International Efforts to Develop Risk-Based Safety Evaluations for Nanomaterials. Toxicol Sci 2006a;92:23–32.
Thomas T, Thomas K, Sadrieh N, et al. Research strategies for safety evaluation of nanomaterials, part VII: evaluating consumer exposure to nanoscale materials. Toxicol Sci 2006;91:14–9.
Warheit DB, Laurence BR, Reed KL, et al. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 2004;77:117–25.
Warheit DB, Webb TR, Colvin VL, et al. Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci 2007;95:270–80.
Wong-Ekkabut J, Baoukina S, Triampo W, et al. Computer simulation study of fullerene translocation through lipid membranes. Nat Nanotechol 2008;3:363–8.
Zhang LW, Monteiro-Riviere NA. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacol Physiol 2008;21:166–80.
Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA. Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol 2008;228:200–11.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jain, K.K. (2012). Nanotoxicology. In: The Handbook of Nanomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-983-9_17
Download citation
DOI: https://doi.org/10.1007/978-1-61779-983-9_17
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-982-2
Online ISBN: 978-1-61779-983-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)