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Translational Cardiology pp 1–38Cite as

Relationship Between Myocardial Ischemia/Reperfusion and Time of Day

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Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Both cardiovascular function and dysfunction exhibit profound time-of-day-dependent oscillations. Coincident with increased sympathetic tone, vascular resistance, and pro-thrombolytic potential, the onset of myocardial infarctions occurs with greatest frequency between 6 a.m. and 12 noon. In addition, the heart exhibits poorest tolerance to ischemia/reperfusion at this time, as evidenced by the extent of cardiac injury. Temporal rhythms in both the onset and tolerance of the heart to ischemic episodes are likely the product of complex interactions between extrinsic (e.g., environmental-/behavioral-modulated) and intrinsic (e.g., circadian clock-regulated) factors. Future pharmacological strategies for myocardial infarction prevention and/or minimizing reperfusion injury should consider time-of-day-dependent rhythms in both extrinsic and intrinsic factors.

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Acknowledgments

This work was supported by the National Heart, Lung, and Blood Institute (HL-074259 [MEY]).

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Authors and Affiliations

  1. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    David J. Durgan

  2. Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, 703 19th Street S., ZRB 308, Birmingham, AL, 35294, USA

    Martin E. Young

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  1. David J. Durgan
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  2. Martin E. Young
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Correspondence to Martin E. Young .

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Editors and Affiliations

  1. , The University of North Carolina, McAllister Heart Institute, 6022 - Burnett Womack Building, Chapel Hill, 27599-7075, North Carolina, USA

    Cam Patterson

  2. , The University of North Carolina, McAllister Heart Institute, 103 Mason Farm Road, Chapel Hill, 27599-7525, USA

    Monte S. Willis

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Durgan, D.J., Young, M.E. (2012). Relationship Between Myocardial Ischemia/Reperfusion and Time of Day. In: Patterson, C., Willis, M. (eds) Translational Cardiology. Molecular and Translational Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-891-7_1

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