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Vitamin D Modulates Airway Smooth Muscle Function

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Vitamin D and the Lung

Part of the book series: Respiratory Medicine ((RM,volume 3))

Abstract

Asthma is a disease that manifests as variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation, and that evokes symptoms of wheezing, dyspnea on exertion, cough, and mucus production. Airway smooth muscle (ASM cells) plays a central role in the asthma diathesis and is implicated in all aspects of asthma pathogenesis. Vitamin D deficiency has been associated with asthma and studies suggest a role for vitamin D as a treatment for asthma. In this chapter, we review the effects of 1,25-dihydroxyvitamin D on ASM cells function, including agonist-induced shortening, secretion of inflammatory mediators, and myocyte hypertrophy and hyperplasia.

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  1. Airways Biology Initiative, Pulmonary Allergy & Critical Care Division, Department of Medicine, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Philadelphia, PA, 19104-3413, USA

    Audreesh Banerjee & Reynold A. Panettieri Jr.

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  1. Channing Laboratory, Division of Pulmonary and Critical Care, Harvard Medical School, Brigham and Wome, 181 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Augusto A. Litonjua

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Banerjee, A., Panettieri, R.A. (2012). Vitamin D Modulates Airway Smooth Muscle Function. In: Litonjua, A. (eds) Vitamin D and the Lung. Respiratory Medicine, vol 3. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-888-7_7

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