Hepatocellular Carcinoma in Children

Chapter
Part of the Clinical Gastroenterology book series (CG)

Abstract

Hepatocellular carcinoma (HCC) is the second most common malignant liver tumor in children after hepatoblastoma (HB) and accounts for approximately 0.3% of all pediatric malignancies [1]. The age-adjusted incidence rate of HCC in the United States in children is 0.41 (0.24–0.65) per 1,000,000 population, with no gender predominance [1]. Children with HCC may present at any age, although the incidence is highest between the ages of 10–19 years [1–3].

Abbreviations

α1-AT

Alpha-1-antitrypsin

AJCC

American Joint Committee on Cancer

COG

Children’s Oncology Group

FAP

Familial adenomatous polyposis

FL-HCC

Fibrolamellar HCC

GSD1

Glycogen storage disease type 1

HB

Hepatoblastoma

HCC

Hepatocellular carcinoma

HBV

Hepatitis B virus

HCV

Hepatitis C virus

HT-1

Hereditary tyrosinemia type 1

L3-AFP

Lectin-reactive alpha-fetoprotein

OLT

Orthotopic liver transplantation

PRETEXT

Pretreatment extent of disease

PFIC

Progressive familial intrahepatic cholestasis

SIOPEL

Societé Internationale d’Oncologie Pédiatrique

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Christiane Sokollik
    • 1
  • Abha Gupta
    • 2
  • Simon C. Ling
    • 1
  1. 1.Division of Gastroenterology, Hepatology and Nutrition, Department of PaediatricsUniversity of Toronto, The Hospital for Sick ChildrenTorontoCanada
  2. 2.Division of Hematology/Oncology, Department of PaediatricsUniversity of Toronto, The Hospital for Sick ChildrenTorontoCanada

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