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Oxidative Stress, DNA Damage, and Apoptosis in Male Infertility

  • Tamer M. Said
  • Constanze Fischer-Hammadeh
  • Mohammed Hamad
  • Khaled Refaat
  • Mohamad Eid Hammadeh
Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

Oxidative stress, sperm DNA damage, and apoptosis are associated with male infertility as a cause and as a manifestation. Several clinical conditions and laboratory findings may be indicative of the presence of oxidative stress, sperm DNA damage, and apoptosis. The use of standardized assays for the diagnosis of oxidative stress, sperm DNA damage, and apoptosis should be limited to cases where these conditions are suspected. The identifications of the causative factor for infertility will lead to a specific and subsequently more successful treatment option. In this chapter, we provide a description of the clinical conditions associated with oxidative stress, sperm DNA damage, and apoptosis that lead to male infertility. The different signs and results of laboratory investigations will be provided to highlight manifestations of these conditions. We also describe the impact of oxidative stress, sperm DNA damage, and apoptosis on male fertility and the different approaches that could be used for diagnosis and prevention.

Keywords

Oxidative stress Apoptosis Male infertility Reactive oxygen species Spermatozoa DNA damage Apoptosis 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Tamer M. Said
    • 1
  • Constanze Fischer-Hammadeh
    • 2
  • Mohammed Hamad
    • 3
  • Khaled Refaat
    • 4
  • Mohamad Eid Hammadeh
    • 2
  1. 1.Andrology Laboratory and Reproductive Tissue BankThe Toronto Institute for Reproductive MedicineTorontoCanada
  2. 2.Department of Obstetrics and GynecologyUniversity of SaarlandHomburgGermany
  3. 3.Department of Pharmacology and BiosciencePetra UniversityAmmanJordan
  4. 4.Department of Obstetrics and GynecologyAl Azhar UniversityAssuitEgypt

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