Oxidative Stress and Testicular Torsion

  • Dikmen Dokmeci
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Testicular torsion is a medical urologic syndrome that constitutes a surgical emergency affecting newborns, children, and adolescent boys. The main pathophysiological event in testicular torsion is ischemia (torsion) followed by reperfusion (detorsion) of the testis, and multifactorial mechanisms seem to mediate this condition. Testicular damage after ischemia/reperfusion (I/R) is related to the duration of ischemia and to the severity of the torsion. I/R injury is associated with activation of neutrophils, inflammatory cytokines, and adhesion molecules with increased thrombogenicity, release of massive intracellular calcium, and overgeneration of reactive oxygen species and reactive nitrogen species. Although the results are not conclusive and the molecular mechanism by which antioxidants control male fertility have not yet been clearly identified, several antioxidant enzymes and antioxidant drugs have been studied to prevent such I/R injury in testis. Antioxidant therapy may represent a new option within a broader therapeutic strategy in testicular torsion with oxidative stress-mediated infertility.


Antioxidant İschemia/reperfusion Lipid peroxidation Male infertility Oxidative stress Reactive oxygen/nitrogen species Testicular torsion 





Activating protein


Adenosine triphosphate


Conjugated diene


Computed tomography


Deoxyribonucleic acid


Electrical field stimulation


Epidermal growth factor


Endothelial nitric oxide synthase


Extracellular signal-regulated kinase


Food and Drug Administration


Follicule-stimulating hormone




Glutathione peroxidase


Hypoxia-inducible factor


Heat shock protein




Intercellular adhesion molecule


Insulin-like growth factor




Inducible nitric oxide synthase


c-Jun-NH2-terminal kinase


l-nitro arginine methyl ester


l-nitro monomethyl arginine


Mitogen-activated protein kinase






Magnetic resonance imaging


Nicotinamid adenine dinucleotide phosphate


Nuclear factor kappa B


Neuronal nitric oxide synthase


Nitric oxide


Platelet-activating factor


Poly (adenosine triphosphate-ribose) polymerase


Peroxisome proliferator-activated receptor


Ribonucleic acid


Reactive nitrogen species


Reactive oxygen species


Superoxide dismutase


Thiobarbituric acid reactive substances


Tumor necrosis factor


Vascular cellular adhesion molecule


Vascular endothelial growth factor


Vasoactive intestinal polypeptide


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Pharmacology, Faculty of MedicineTrakya UniversityEdirneTurkey

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